Protein Alignment Prm and CGNL1

DIOPT Version :10

• Sequence 1: NP_523982.2
• Gene: Prm / 39002
• FlyBaseID: FBgn0003149
• Length: 879
• Species: Drosophila melanogaster
• Sequence 2: XP_005254783.1
• Gene: CGNL1 / 84952
• HGNCID: 25931
• Length: 1303
• Species: Homo sapiens
• Alignment Length: 885
• Identity: 207/885 - (23%)
• Similarity: 379/885 - (42%)
• Gaps: 187/885 - (21%)

  Fly    15 RATSTGP--GTADVNIEYIQDLSSLSRLEDKIRLLQDDLEVERELRQRIEREKADLSVQVIQMSE 77
            |||:|.|  |...::::.....|:.....|.       |:.::||.|:...|.|.   |::....
Human   509 RATATSPDSGAKKISVKTFPSASNTQATPDL-------LKGQQELTQQTNEETAK---QILYNYL 563

  Fly    78 RLEEAEGGAEHQFEANRKRDAELLKLRKLL-----------EDVHLESEETTLLLKKKHNEI-IT 130
            :    ||..::.....||.:....|::.|.           :..:..||...||.:|....| :.
Human   564 K----EGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVA 624

  Fly   131 DFQEQVEILTKNKARAEKDKAKFQTEVYELLSQIESYNKEKIVSEKHI-SKLEVSISELNVKIEE 194
            :.|.|:::..||:...::::.:.:..:.||.||    :.||:.....: .:||.|..||...:||
Human   625 ELQRQLQLEVKNQQNIKEERERMRANLEELRSQ----HNEKVEENSTLQQRLEESEGELRKNLEE 685

  Fly   195 LNRTVIDISSHRSRLSQENIELTKDVQDLKVQLDTVSFSKSQVISQLEDARRRLEDEDRRRSLLE 259
            |.:..::...|::           :::||:.||       |::..:|:.|:|   .|||.:..|.
Human   686 LFQVKMEREQHQT-----------EIRDLQDQL-------SEMHDELDSAKR---SEDREKGALI 729

  Fly   260 SSLHQVEIELDSVRNQLEEESEARIDLERQLVKANADATSWQNKWNSEVAARAEEVEEIRRKYQV 324
            ..|.|.:.:|..:....||:.:.....||:|       |:.:.....||::..:|:::::.:|..
Human   730 EELLQAKQDLQDLLIAKEEQEDLLRKREREL-------TALKGALKEEVSSHDQEMDKLKEQYDA 787

  Fly   325 RITELEE-------HIESLIVKVNNLEKMKTRLASEVEVLIIDLEKSNNSCRELTKSVNTLEKHN 382
            .:..|.|       ::|.|..:.|..|:.:......|::|..:.||......||.:.|..|::..
Human   788 ELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQI 852

  Fly   383 VELK---SRLDETIILYETSQRDL---------KNKHADLVRTV--HELDKVKDNNNQLTRENKK 433
            .:||   ::..||:..||...|.|         :.|.|...|..  :||:..:.|.:|.|:|.|:
Human   853 EDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQ 917

  Fly   434 LGDDLHEAKGAINELNRRLHELELE-------LRRLENERDELTAAYKEAEAGRKAEEQRGQRLA 491
            |.:.|.|......:|.|..:|:|.|       :.:|:.|..::      .||.|.:..:    |.
Human   918 LSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADI------VEASRTSTLE----LQ 972

  Fly   492 ADFNQYRHDAERRLAEKDEEIEAIRKQTSIEIEQLNARVIEAETRLKTEVTRIKKKLQIQITELE 556
            ...::|:....|.|||..              .||..:.:|||   |:.:|.:|.:.::::.|.|
Human   973 NQLDEYKEKNRRELAEMQ--------------RQLKEKTLEAE---KSRLTAMKMQDEMRLMEEE 1020

  Fly   557 MSLDVANKTNIDLQKVIKKQSLQLTELQAHYEDVQRQLQATLDQYAVAQRRLAGLNGELEEVRSH 621
            :                              .|.||.....|.:..:.::.|..|..|| |.:||
Human  1021 L------------------------------RDYQRAQDEALTKRQLLEQTLKDLEYEL-EAKSH 1054

  Fly   622 L-DSANRAKRTVELQYEEAASRINELTTANVSLVSIKSKLEQELSVVASDYEEVSKELRISDERY 685
            | |..:|..:.:|.:.                     |:||.||....::.:.:|:  |||..|.
Human  1055 LKDDRSRLVKQMEDKV---------------------SQLEMELEEERNNSDLLSE--RISRSRE 1096

  Fly   686 QKVQVELKHVVEQVHEE--QERIVK--LETIKKSLEVEVKNLSIRLEEVELNAVAGSKRIISKLE 746
            |         :||:..|  |||..:  ||..|.|||.:.|:|..|:..:|.:..:..:.::.::|
Human  1097 Q---------MEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQME 1152

  Fly   747 ARIRDLELELEEEKRRHAETIKILRKKERTVKEVLVQCEEDQKNLILLQDALDKSTAKINIYRRQ 811
            |||.:||..||.|:|..|......|:.||.|||:::|.:::.   :.|.|..|:.:.::...:||
Human  1153 ARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEH---LSLTDQKDQLSLRLKAMKRQ 1214

  Fly   812 LSEQEGVSQQTTTRVRRFQRELEAAEDRADTAESSLNIIR 851
            :.|.|....:..:..::.|||||...|..:..:..||.::
Human  1215 VEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMK 1254

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prm	NP_523982.2	Myosin_tail_1	<34..853	CDD:460256	201/864 (23%)
CGNL1	XP_005254783.1	Myosin_tail_1	<615..1257	CDD:460256	182/765 (24%)