DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prm and MYO18B

DIOPT Version :9

Sequence 1:	NP_523982.2	Gene:	Prm / 39002	FlyBaseID:	FBgn0003149	Length:	879	Species:	Drosophila melanogaster
Sequence 2:	XP_011528760.1	Gene:	MYO18B / 84700	HGNCID:	18150	Length:	2610	Species:	Homo sapiens

Alignment Length:	908	Identity:	202/908 - (22%)
Similarity:	364/908 - (40%)	Gaps:	230/908 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 GGAEH--------QFEANRKRDAELLKL----------RKLLEDVHLESEETTLLLKKK-----H 125
            |.|:|        ||:.   .||.|||.          ||.:|:: ||    ||.|:||     |
Human  1302 GYADHMGLTRFRRQFQV---LDAPLLKKLMSTSEGIDERKAVEEL-LE----TLDLEKKAVAVGH 1358

  Fly   126 NE------IITDFQEQVEILTKNK------------ARAEKDKAK--------FQTEV------- 157
            ::      :|:..::|.|.|....            :|.|..|.|        .|..|
Human  1359 SQVFLKAGVISRLEKQREKLVSQSIVLFQAACKGFLSRQEFKKLKIRRLAAQCIQKNVAVFLAVK 1423

  Fly   158 ----YELLSQIESYNKEKIVSEKHISKLEVSISELNVKIEELNRTVIDISSHRSRLSQENIELTK 218
                ::||..::......|.:|:..:| |..::.|..|:|:..:...::..:...|..:..:||.
Human  1424 DWPWWQLLGSLQPLLSATIGTEQLRAK-EEELTTLRRKLEKSEKLRNELRQNTDLLESKIADLTS 1487

  Fly   219 DVQDLKVQLDTVSFSKSQVISQLEDARRRLEDEDRRRSLLESSLHQVEIELDSVRNQLEEESEAR 283
            |:.|.:.:.|..    .||   ||..|.......|....|:|...||:.:|..|..|| ||::.:
Human  1488 DLADERFKGDVA----CQV---LESERAERLQAFREVQELKSKHEQVQKKLGDVNKQL-EEAQQK 1544

  Fly   284 I---DLERQLVKANADATSWQNKW------NSEVAARAEEVEE-------IRRKYQVRITELEEH 332
            |   ||||   .....|..||.::      |..:..|.::.||       .|::.:.::.||:..
Human  1545 IQLNDLER---NPTGGADEWQMRFDCAQMENEFLRKRLQQCEERLDSELTARKELEQKLGELQSA 1606

  Fly   333 IESLIVKVNNLEKMKTRLASEVEVLIIDLEKSNNSCRELTKSVNTLEKHNVELKSRLDETI---- 393
            .:......:.|::....|..::|...:.||...:...||.|.   .:|.:::|...|.|::
Human  1607 YDGAKKMAHQLKRKCHHLTCDLEDTCVLLENQQSRNHELEKK---QKKFDLQLAQALGESVFEKG 1668

  Fly   394 -----------ILYETS--QRDLKNKHADLVRTVHELDKVKDNNNQLTRENKKLGDDLHEAKGAI 445
                       :.:|..  |:.||.|..:..:...:::.::|:..:|. .:..||::      .:
Human  1669 LREKVTQENTSVRWELGQLQQQLKQKEQEASQLKQQVEMLQDHKRELL-GSPSLGEN------CV 1726

  Fly   446 NELNRRLHELE---LELRRLENERDELTAAYKEAEAGRKAEEQRGQRLAADFNQYRHDAERRLAE 507
            ..|..||.:||   ||.::::::::...          |..||..||...:..:.:...::...:
Human  1727 AGLKERLWKLESSALEQQKIQSQQENTI----------KQLEQLRQRFELEIERMKQMHQKDRED 1781

  Fly   508 KDEEIEAIRKQTSIEIEQLNARVIEAETRLKTEVTRIKKKLQIQITELEMSLDVANKTNIDLQKV 572
            ::||:|.:|:.....:.||..: :|.|...|..|...|:.|:..|..|   .|.....:.|::|.
Human  1782 QEEELEDVRQSCQKRLHQLEMQ-LEQEYEEKQMVLHEKQDLEGLIGTL---CDQIGHRDFDVEKR 1842

  Fly   573 IKKQSLQLTELQAHYEDVQRQLQATLDQYAVAQRRLAGLNGELEEVRSHLDSANRAKRTVELQYE 637
            :::   .|....|...|||..|....|......:.      |||:|.|.|:.:       |.:.|
Human  1843 LRR---DLRRTHALLSDVQLLLGTMEDGKTSVSKE------ELEKVHSQLEQS-------EAKCE 1891

  Fly   638 EAASRINELTTANVSLVSIKSKLEQELSVVASDYEEVSKELRISDERYQKVQVELKHVVEQVHEE 702
            ||      |.|..|        |..:|..:.|:.|.:::...:.||:..::|.|...:::::.|:
Human  1892 EA------LKTQKV--------LTADLESMHSELENMTRNKSLVDEQLYRLQFEKADLLKRIDED 1942

  Fly   703 QERI-------------------------VKLETIKK---SLEVEVKNLSIRLEEVELNAVAGSK 739
            |:.:                         ::||..||   .|:.:::...:|:|.:|.:.|  .:
Human  1943 QDDLNELMQKHKDLIAQSAADIGQIQELQLQLEEAKKEKHKLQEQLQVAQMRIEYLEQSTV--DR 2005

  Fly   740 RIISKLEARIRDLELELEEEKRRHAETIKILRKKERTVKEVLVQCEEDQKNLILLQDALDKSTAK 804
            .|:|:.||.|.|||.:.|.:|      ::|.|      .||||         |.|:|:|.|...:
Human  2006 AIVSRQEAVICDLENKTEFQK------VQIKR------FEVLV---------IRLRDSLIKMGEE 2049

  Fly   805 INIYRRQLSEQEGVSQQTTTRVRRF--------QRELEAAEDRADTAESSLNIIRAKHRTFVT 859
            ::......|:|...||....|:...        |||.||:. |....|..:..:.|..:|..|
Human  2050 LSQAATSESQQRESSQYYQRRLEELKADMEELVQREAEASR-RCMELEKYVEELAAVRQTLQT 2111

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prm	NP_523982.2	Myosin_tail_1	<34..853	CDD:279860	199/900 (22%)
MYO18B	XP_011528760.1	Glutenin_hmw	<114..542	CDD:281191
		MYSc	608..1376	CDD:214580	23/81 (28%)
		MYSc_Myo18	627..1364	CDD:276837	21/69 (30%)
		Smc	1457..>2133	CDD:224117	165/744 (22%)
		GBP_C	<1723..1818	CDD:303769	22/111 (20%)
		coiled coil	1789..1803	CDD:293879	3/13 (23%)
		RILP-like	1923..>2020	CDD:304877	21/98 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810