DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prm and ATM2

DIOPT Version :9

Sequence 1:	NP_523982.2	Gene:	Prm / 39002	FlyBaseID:	FBgn0003149	Length:	879	Species:	Drosophila melanogaster
Sequence 2:	NP_001078755.1	Gene:	ATM2 / 835516	AraportID:	AT5G54280	Length:	1220	Species:	Arabidopsis thaliana

Alignment Length:	1006	Identity:	196/1006 - (19%)
Similarity:	349/1006 - (34%)	Gaps:	257/1006 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 PGTADVNIEYIQDLSSLSRLED-------KIRLLQDDLEVERELRQRIEREKADLSVQVIQMSER 78
            |...|: :|.::||..||.|.:       ::|.|||           :...||...:..:...:.
plant   206 PANPDI-LEGVEDLIQLSYLNEPSVLYNLRVRYLQD-----------VIYSKAGPVLIAVNPFKN 258

  Fly    79 LEEAEGGAEHQFEANRKRDAELLKLRKLLEDVHLESEETTLLLKKKHNEIITDFQEQVEILTKNK 143
            :|.........::            :|:::..|:.:     :....::|::.:.:.|..|::...
plant   259 VEIYGNDVISAYQ------------KKVMDAPHVYA-----VADAAYDEMMREEKNQSLIISGES 306

  Fly   144 ARAEKDKAKFQTEV------------YELLSQ---IESYNKEKIVSEKHISK----LEVSISEL- 188
            ...:.:.|||..:.            ||:|..   :|::...|.....:.|:    :|:..|.:
plant   307 GAGKTETAKFAMQYLAALGGGSCGVEYEILKTTCILEAFGNAKTSRNANSSRFGKLIEIHFSAMG 371

  Fly   189 ---NVKIE----ELNRTVIDISSHRS-----RLSQENIELTKDVQDLKVQLDTVSFSKSQ--VIS 239
               ..|:|    |.:|.|...:..||     .|......:.|:...||...:....|:|.  .|:
plant   372 KICGAKLETFLLEKSRVVQLFNGERSYHIFYELCAGASPILKERLKLKTASEYTYLSQSDCLTIA 436

  Fly   240 QLEDARR--RL-----------EDEDRRRSLLESSL-------------HQVEIELD-SVRNQLE 277
            .::||::  :|           |.::|..:||.:.|             :.||:..| :|.|...
plant   437 GVDDAQKFHKLLEAFDIVQIPKEHQERAFALLAAVLWLGNVSFRVTDNENHVEVVADEAVANAAM 501

  Fly   278 ----EESEARIDLERQLVKANAD----------ATSWQN-----------KWNSEVAARAEEVEE 317
                ...|..:.|..:.::|..|          ||..::           .|..|....|.||.:
plant   502 LMGCNTEELMVVLSTRKLQAGTDCIAKKLTLRQATDMRDGIAKFIYANLFDWLVEQINIALEVGK 566

  Fly   318 IRRKYQVRITELEEHIESLIVKVNNLEKMKTRLASE-------------------------VEVL 357
            .|....:.|.:: ...||.  |.|:.|:.....|:|                         .:|.
plant   567 SRTGRSISILDI-YGFESF--KNNSFEQFCINYANERLQQHFNRHLFKLEQEEYEEDGIDWTKVE 628

  Fly   358 IIDLEKSNNSCRELTKSVNTLEKHNVELKSRLDETIILYETSQRDLKNKHADLVRTVHELDKVKD 422
            .:|    |..|.:|      :||..:.|.|.|||.....:.:.....||....::|   ....|.
plant   629 FVD----NQECLDL------IEKKPIGLLSLLDEESNFPKATDLTFANKLKQHLKT---NSCFKG 680

  Fly   423 NNNQLTRENKKLGDDLHEAKGAINELNRRLHELELELRRLENERD-ELTAAYKEAEAGRKAE--- 483
            ...:..|.|...|:.|::..|.: |.||  ..|..:|..|.:..| :|...:.....|:..:
plant   681 ERGRAFRVNHYAGEVLYDTNGFL-EKNR--DPLPADLINLLSSCDCQLLKLFSTKMRGKSQKPLM 742

  Fly   484 --EQRGQRLAADFNQYRHDAERRLAEKDEEIEAIRKQTSIEIEQLNARVIEAETRLK-------T 539
              :...|.:...|.........:|...........|..|.::    .||.|.:..|:       .
plant   743 LSDSTNQTVGTKFKGQLFKLMNKLENTSPHFIRCIKPNSKQL----PRVYEEDLVLQQLRCCGVL 803

  Fly   540 EVTRIKKK-LQIQITELE------------------MSLDVANKTNIDLQKVIKKQSLQLTELQA 585
            ||.||.:. ...::|..|                  :|:.:|         |:|:..:.....|.
plant   804 EVVRISRSGYPTRLTHQEFAGRYGFLLSDKKVAQDPLSVSIA---------VLKQYDVHPEMYQV 859

  Fly   586 HYEDVQRQLQATLDQYAVAQRR----LAGLNGELEEVRSHLDSA---NRAKRTVELQ---YEEAA 640
            .|    .:|.....|..:.:.|    |.|:.|..:..|.||..|   |..|.|:.||   ..|.|
plant   860 GY----TKLYLRTGQIGIFEDRRKKVLQGIVGLQKHFRGHLSRAYFQNMRKVTLVLQSYIRGENA 920

  Fly   641 SRINELTTANVSLVSIKSKLEQELSVVASDYEEVSKELRISDERYQKVQVELKHVVEQVHEEQER 705
            .|:.: |.|.....|:......|||.|......|...|........:.|.||::|..:...:..|
plant   921 RRLFD-TEAKFHADSVSEASTDELSAVIHLQSAVRGWLARKHFNSMQRQKELRNVATKSKRKAGR 984

  Fly   706 IVKLETIKKSLEVEVKNLSIRLEEVELNAVAGSKRIISKLEARIRDLELE---LEEEKRRHAETI 767
            .:.          |.|::.:...:|:..:::..::.|.|.||.:...|.|   |.|:.|:..|
plant   985 RIS----------EDKDIPLEQPQVQPTSMSDLQKRILKSEAALSQKEEENTALREQLRQFEE-- 1037

  Fly   768 KILRKKERTVKEVLVQCEED-QKNLILLQDALDKSTAKINIYRRQLSEQEGVSQQTTTRVRRFQR 831
               |..|..:|  :...||. ||.:..||.:|  :.|:.::....::.|.|..|.|:  :..|
plant  1038 ---RWSEYDIK--MKSMEETWQKQMSSLQMSL--AAARKSLAAESITGQAGGRQDTS--ISPF-- 1091

  Fly   832 ELEAAEDRADTAESSLNIIRAKHRTFVTTST 862
                ..|..||..:....:|.....|...:|
plant  1092 ----GYDSEDTMSTGTPGVRTPTNKFTNGNT 1118

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prm	NP_523982.2	Myosin_tail_1	<34..853	CDD:279860	190/982 (19%)
ATM2	NP_001078755.1	MYSc	208..879	CDD:214580	131/735 (18%)
ATM2	NP_001078755.1	MYSc_Myo8	227..867	CDD:276834	122/703 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910