DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prm and Myh10

DIOPT Version :9

Sequence 1:	NP_523982.2	Gene:	Prm / 39002	FlyBaseID:	FBgn0003149	Length:	879	Species:	Drosophila melanogaster
Sequence 2:	XP_008766103.1	Gene:	Myh10 / 79433	RGDID:	71000	Length:	2007	Species:	Rattus norvegicus

Alignment Length:	830	Identity:	222/830 - (26%)
Similarity:	428/830 - (51%)	Gaps:	30/830 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 LEDKIRLLQDDLEVERELRQRIEREKADLSVQVIQMSERLEEAEGGAEHQFEANRKRDAELLKLR 104
            |:.:|..||:|.|.|:..|.:.|::|.|||.::..:...||:.......|.|...||:.|:.:|:
  Rat  1147 LQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELK 1211

  Fly   105 KLLEDVHLESEETTLLLKKKHNEIITDFQEQVEILTKNKARAEKDKAKFQTEVYELLSQIESYNK 169
            |.|||.....|.....::::|...:.:..||:|...:.||..||:|...:|:..||..:::...:
  Rat  1212 KALEDETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQ 1276

  Fly   170 EKIVSEKHISKLEVSISELNVKIEELNRTVIDISSHRSRLSQE--NIELTKDVQDLKVQLDTVSF 232
            .|..||....||:..:.||:.|:.|.:|..::::...::|..|  |:....:..:.|    .:.|
  Rat  1277 VKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKANKLQNELDNVSTLLEEAEKK----GMKF 1337

  Fly   233 SK--SQVISQLEDARRRLEDEDRRRSLLESSLHQVEIELDSVRNQLEEESEARIDLERQLVKANA 295
            :|  :.:.|||:|.:..|::|.|::..|.|.:.|:|.|.:|::.|.|||.|||.:||:|::...:
  Rat  1338 AKDAAGLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQS 1402

  Fly   296 DATSWQNKWNSEVAARAEEVEEIRRKYQVRITELEEHIESLIVKVNNLEKMKTRLASEVEVLIID 360
            .....:.|.:.::.. .|.:||.::|....:..|.:.:|..::..:.|||.|.||..|::.|.:|
  Rat  1403 QLADTKKKVDDDLGT-IEGLEEAKKKLLKDVEALSQRLEEKVLAYDKLEKTKNRLQQELDDLTVD 1466

  Fly   361 LEKSNNSCRELTKSVNTLEKHNVE---LKSRLDETIILYETSQRDLKNKHADLVRTVHELDKVKD 422
            |:........|.|.....::...|   :.:|..|.....|...|:.:.|...|.|.:.|..:.|:
  Rat  1467 LDHQRQIVSNLEKKQKKFDQLLAEEKGISARYAEERDRAEAEAREKETKALSLARALEEALEAKE 1531

  Fly   423 NNNQLTRENKKLGDDLHEAKGAINELNRRLHELELELRRLENERDELTAAYKEAEAGRKAEEQRG 487
               :..|:||:|..|:.:...:.:::.:.:||||...|.||.:.:|:....:|.|...:|.|...
  Rat  1532 ---EFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAK 1593

  Fly   488 QRLAADFNQYRHDAERRLAEKDEEIEAIRKQTSIEIEQLNARVIEAETRLKTEVTRIKKKLQIQI 552
            .||..:....:...||.|..:||:.|..::....::.:|.|. :|.|.:.:......|||::|.:
  Rat  1594 LRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLLKQVRELEAE-LEDERKQRALAVASKKKMEIDL 1657

  Fly   553 TELEMSLDVANKTNIDLQKVIKKQSLQLTELQAHYEDVQRQLQ---ATLD----QYAVAQRRLAG 610
            .:||..::.|||..   .:|||    ||.:|||..:|.||:|:   |:.|    |...::::|..
  Rat  1658 KDLEAQIEAANKAR---DEVIK----QLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKS 1715

  Fly   611 LNGELEEVRSHLDSANRAKRTVELQYEEAASRINELTTANVSLVSIKSKLEQELSVVASDYEEVS 675
            |..|:.:::..|.|:.||:|..|.:.:|.|..|....:...:|:..|.:||..::.:..:.||..
  Rat  1716 LEAEILQLQEELASSERARRHAEQERDELADEIANSASGKSALLDEKRRLEARIAQLEEELEEEQ 1780

  Fly   676 KELRISDERYQKVQVELKHVVEQVHEEQERIVKLETIKKSLEVEVKNLSIRLEEVELNAVAGSKR 740
            ..:.:.::|::|..:::..:..::..|:....|.:..::.||.:.|.|..:|:|:|....:..|.
  Rat  1781 SNMELLNDRFRKTTLQVDTLNTELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKA 1845

  Fly   741 IISKLEARIRDLELELEEEKRRHAETIKILRKKERTVKEVLVQCEEDQKNLILLQDALDKSTAKI 805
            .||.|||:|..||.:||:|.:..|...|::|:.|:.:||:.:|.|:::::....::.::|:.|::
  Rat  1846 TISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARM 1910

  Fly   806 NIYRRQLSEQEGVSQQTTTRVRRFQRELEAAEDRADTAESSLNIIRAKHR 855
            ...:|||.|.|..:.:.....|:.||||:.|.:..:.....::.::.:.|
  Rat  1911 KQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLR 1960

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prm	NP_523982.2	Myosin_tail_1	<34..853	CDD:279860	221/826 (27%)
Myh10	XP_008766103.1	Myosin_N	34..72	CDD:280832
		Myosin_head	87..802	CDD:278492
		MYSc_Myh10	99..802	CDD:276952
		Myosin_tail_1	879..1959	CDD:279860	221/827 (27%)
		DUF2317	<1142..1253	CDD:302887	32/105 (30%)
		ApoLp-III_like	1224..1371	CDD:304399	37/150 (25%)
		GBP_C	<1535..1641	CDD:303769	29/106 (27%)
		coiled coil	1631..1641	CDD:293879	4/10 (40%)
		DUF106	<1676..>1727	CDD:303007	16/54 (30%)
		DUF2570	1800..>1898	CDD:305162	29/97 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900