DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prm and Myo18b

DIOPT Version :9

Sequence 1:	NP_523982.2	Gene:	Prm / 39002	FlyBaseID:	FBgn0003149	Length:	879	Species:	Drosophila melanogaster
Sequence 2:	NP_083177.2	Gene:	Myo18b / 74376	MGIID:	1921626	Length:	2605	Species:	Mus musculus

Alignment Length:	1074	Identity:	222/1074 - (20%)
Similarity:	415/1074 - (38%)	Gaps:	321/1074 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSSQAVRSSKYSYRATSTGPGTADVNIEYIQDLSSLSRLEDK-----IRLLQDDL---------- 51
            :|.||:..|:...||.:                |||:.::.|     |:|..|.|
Mouse  1190 TSQQALHRSRVVRRAFA----------------SSLAAVKRKAPCAQIKLQMDALISLLRRSRLH 1238

  Fly    52 --------EVERELRQR------------IEREKADLSVQVIQM---------SERLEEAEGGAE 87
                    .||.:..||            :..|...|.:..:::         :.||..| |.||
Mouse  1239 FIHCLVPTTVESKAGQRTPSPSQPSGDQGVANEPTALDIPALRVQLAGSHILEALRLHRA-GYAE 1302

  Fly    88 HQFEANRKRDAELLKLRKLLEDVHLESEE-----------TTLLLKKK-----HNE------IIT 130
            |...|..:|..::|. ..||:.:.|.|||           .||.|:||     |::      :::
Mouse  1303 HMGLAQFRRRFQVLD-PALLKKLDLTSEELDERKVVEELLKTLDLEKKAVAVGHSQVFLKAGVVS 1366

  Fly   131 DFQEQVEILTKNK------------ARAEKDKAKFQ--------------------------TEV 157
            ..:.|.|.|....            :|.|..|.|.:                          ..:
Mouse  1367 RLERQREKLVSRNIVLFQAACRGFLSRQEYKKLKIRRLATLCIQKNLAVFLKVKDWPWWGLLASL 1431

  Fly   158 YELLS------QIESYNKEKIVSEKHISKLEVSISELNVKIEELNRTVIDISSHRS--RLS---- 210
            ..|||      |:.:..:|..:..:.:.|.|.|.|||....:.|...:.|::|..:  |..
Mouse  1432 RPLLSSTLGTEQLRAKEEELTLLRQKLQKSENSRSELRQNTDLLESKITDLTSELADERFKGDVA 1496

  Fly   211 --------QENIELTKDVQDLKVQLDTVSFSKSQVISQLEDARRRLE------------DEDRRR 255
                    .|.::..::||:||.:...|..:..:|..|||:|::|::            ||.:.|
Mouse  1497 CQALESERAERLQALREVQELKTKYQQVQDALGEVQKQLEEAQQRIQGANLEEKPAGGADEWQMR 1561

  Fly   256 SLLESSLHQVEIELDSVRNQLEEESEARIDLERQLVKANADATSWQNKWNSEVAARAEEVEEIRR 320
                  |...::|.|.:|.:| ::.|.|:|                    ||:.||
Mouse  1562 ------LDCAQMENDFLRKRL-QQCEERLD--------------------SEMKAR--------- 1590

  Fly   321 KYQVRITELEEHIESLIVKVNNLEKMKTRLASEVEVLIIDLEKS-----NNSCR--ELTKSVNTL 378
                  ||||:.:..|.......:||..:|..:...|..|||.:     |...|  ||.|   ..
Mouse  1591 ------TELEQKLGELQSAYEEAKKMAHQLKRKCHHLTWDLEDTRVLLENQQSRNHELEK---RQ 1646

  Fly   379 EKHNVELKSRLDETIILYETSQRDLKNKHADLVRTVHELDKVKDNNNQLTRENKKLGDDLHEAKG 443
            :|.:::|...|.|:  ::|.|.|:..::..:.||  .||.:::....|..:|..||..::...:|
Mouse  1647 KKFDLQLAQALGES--MFEKSLREKVSQENNGVR--WELGQLQQQLEQKEQEASKLKQEVERLQG 1707

  Fly   444 --------------AINELNRRLHELE---LELRRLENERDELTAAYKEAEAGRKAEEQRGQRLA 491
                          .:..|..|:.|||   ||.:::.::::...          |..||..||..
Mouse  1708 QKRELLSCASVGDQGVASLKERVWELETNALEQQKIHSQQENTI----------KQLEQLRQRFE 1762

  Fly   492 ADFNQYRHDAERRLAEKDEEIEAIR-------KQTSIEIE------------------------- 524
            .:..:.:...::...:::||:|.:|       :|..:::|
Mouse  1763 LEIERMKQMHQKDREDQEEELEDVRQSCQKRLRQLEMQLEQEYEEKQVALHEKHDLEGLIGTLCD 1827

  Fly   525 QLNARVIEAETRLKTEVTR---IKKKLQIQITELEMSLDVANKTNIDLQKVIKKQSLQLTELQAH 586
            |:..|..:.|.||:.::.|   :...:|:.:..:|.|     ||:|..:::.|..| ||.:.:|.
Mouse  1828 QIGHRDFDVEKRLRRDLRRTHALLSDVQLLLATIEDS-----KTSISKEELEKVHS-QLEQSEAK 1886

  Fly   587 YEDVQRQLQATLDQYAVAQRRLAGLNGELEEVRSHLDSANRAKRTVE-----LQYEEA--ASRIN 644
            .||..:..:.              |..:||.:.|.|::..|:|..|:     ||:|.|  ..||:
Mouse  1887 CEDALKTQKV--------------LTADLENMHSELENVTRSKSLVDEQLYRLQFERADLLKRID 1937

  Fly   645 ELTTANVSLVSIKSKLEQELSVVASDYEEVSKELRISDERYQKVQVELKHVVEQVHEEQERIVKL 709
            |   ....|..:..|.:..::..|:|..:: :||::..|..:|.:.:|:   ||:|..|.||..|
Mouse  1938 E---DQGDLNDLMQKHKDLIAQSAADIGQI-QELQLQLEETKKEKQKLR---EQLHMAQLRIQYL 1995

  Fly   710 E--TIKKSLEVEVKNLSIRLEEVELNAVAGSKRIISKLEA---RIRDLELELEEEKRRHAETIKI 769
            |  |:::::....:.:...||    |.....|..|.:.|.   |:||..:::.||..|..:....
Mouse  1996 EQSTVERAIVSRQEAIICDLE----NKTEFQKVQIKRFEVLVIRLRDSMIKMGEELSRAVKAEAQ 2056

  Fly   770 LRKKERTVKEVLVQCEEDQKNLILLQDALDKSTAKINIYRRQLSE-QEGVSQQTTTRVRRFQREL 833
            .|:..:..::.|.:.:.:.:.|...::...:...::..|..:|:. ::.:.....|.:||. .:|
Mouse  2057 QRENSQYYQQRLEELKAEMQELAQREEEASRRCMELEKYVEELATVRQTLQTDLETSIRRI-ADL 2120

  Fly   834 EAAEDRADTAESSLNIIRAKHRTFVTTSTVPGSQ 867
            :||.:...:::|....:    :|.|..|:..|.:
Mouse  2121 QAALEEVVSSDSDTESV----QTAVDCSSRSGKE 2150

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prm	NP_523982.2	Myosin_tail_1	<34..853	CDD:279860	212/1026 (21%)
Myo18b	NP_083177.2	PHA03247	<55..472	CDD:223021
		COG5022	606..2126	CDD:227355	217/1044 (21%)
		MYSc_Myo18	625..1361	CDD:276837	42/188 (22%)
		CEP170_C	2123..>2365	CDD:373735	6/32 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900