DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Prm and MYO5C

DIOPT Version :9

Sequence 1:NP_523982.2 Gene:Prm / 39002 FlyBaseID:FBgn0003149 Length:879 Species:Drosophila melanogaster
Sequence 2:NP_061198.2 Gene:MYO5C / 55930 HGNCID:7604 Length:1742 Species:Homo sapiens


Alignment Length:901 Identity:167/901 - (18%)
Similarity:326/901 - (36%) Gaps:280/901 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    90 FEANRKRDAELLKLRKLLEDVHLESEE-----TTLLLKKKHNEIIT----DFQEQVEILTKNKAR 145
            ||.:.||..:.|:...:||.:.:.::.     |.:....::..::|    .|.::.|:......|
Human   659 FEFDSKRIVQQLRACGVLETIRISAQSYPSRWTYIEFYSRYGILMTKQELSFSDKKEVCKVVLHR 723

  Fly   146 AEKDKAKFQTEVYELLSQIESYNKEKIVSEK-HISKLEVSISELNVKIEELNRTVIDISSH-RSR 208
            ..:|..::|            :.|.||.... .::.||      .:::::|.::.:.:..| |..
Human   724 LIQDSNQYQ------------FGKTKIFFRAGQVAYLE------KLRLDKLRQSCVMVQKHMRGW 770

  Fly   209 LSQENIELTKDVQDLKVQLDTVSFSKSQ-------VISQLEDARRRLEDEDRRRSLLESSLHQVE 266
            |.::     |.:::.:..|....:.:.|       ....|::|...:..:...|..|..||:|: 
Human   771 LQRK-----KFLRERRAALIIQQYFRGQQTVRKAITAVALKEAWAAIIIQKHCRGYLVRSLYQL- 829

  Fly   267 IELDSV---------------RNQLEEESEARID------------------------------L 286
            |.:.::               |..|||.....:.                              |
Human   830 IRMATITMQAYSRGFLARRRYRKMLEEHKAVILQKYARAWLARRRFQSIRRFVLNIQLTYRVQRL 894

  Fly   287 ERQLVKANADATSWQNKWNSEVAARAEEVEEIRRKYQVRITELEEHIESLIVKVNNLEKMKTRLA 351
            :::|...|.:......|..|..|.||.:||:|::        ||..:|.......|.|:...|..
Human   895 QKKLEDQNKENHGLVEKLTSLAALRAGDVEKIQK--------LEAELEKAATHRRNYEEKGKRYR 951

  Fly   352 SEVEVLIIDLEKSNNSCRELTKSVNTLEKHNVELKSRLDETIILYETSQRDLKNKHADLVRTVHE 416
            ..||             .:|.|    |:|||.||:::.::..:..:....:||.|..:|      
Human   952 DAVE-------------EKLAK----LQKHNSELETQKEQIQLKLQEKTEELKEKMDNL------ 993

  Fly   417 LDKVKDNNNQLTRENKKLGDDLHEAKGAINELNRRLHELELELRRLENERDELTAAYKEAEAGRK 481
                          .|:|.||:.:     .|..|.|.|...||:                     
Human   994 --------------TKQLFDDVQK-----EERQRMLLEKSFELK--------------------- 1018

  Fly   482 AEEQRGQRLAADFNQYRHDAERRLAEKDEEIEAIRKQTSIEIEQLNARVIEAE----TRLKTEVT 542
                            ..|.|:::....|||:|: |...::::.|    :|.|    ..||.||.
Human  1019 ----------------TQDYEKQIQSLKEEIKAL-KDEKMQLQHL----VEGEHVTSDGLKAEVA 1062

  Fly   543 RIKKKLQIQITELEMSLDVANKTNIDLQKVIKKQSLQLTELQAHYEDVQRQLQATLDQYAVAQRR 607
            |:.|::: .|:|.|..:::.....||::|.::.|..::.|..:   ::.:||   |:.|      
Human  1063 RLSKQVK-TISEFEKEIELLQAQKIDVEKHVQSQKREMREKMS---EITKQL---LESY------ 1114

  Fly   608 LAGLNGELEEVRSHLDSANRAKRTVELQYEEAASRINELTTANVSLVSIKSKLEQELSVVASDYE 672
                  ::|:|||.|          .::..|..:...||..|...|......||.........||
Human  1115 ------DIEDVRSRL----------SVEDLEHLNEDGELWFAYEGLKKATRVLESHFQSQKDCYE 1163

  Fly   673 EVSKELRISDERYQKVQVELKHVVEQVHEEQERIVKLETIKKSLEVEVKNLSIRLEEVELNAVAG 737
               ||:...:.:...:..|:.|:.:...||.:       |.:|:..||..|:     .|...:..
Human  1164 ---KEIEALNFKVVHLSQEINHLQKLFREEND-------INESIRHEVTRLT-----SENMMIPD 1213

  Fly   738 SKRIISKLEARIRDLELELEEEKRRHAETIKIL-------RKKERTVKEVL-----VQCEEDQKN 790
            .|:.||:||.:.:|||:.|.|:..:....::.|       :::|.|.::.|     :..:|.:|.
Human  1214 FKQQISELEKQKQDLEIRLNEQAEKMKGKLEELSNQLHRSQEEEGTQRKALEAQNEIHTKEKEKL 1278

  Fly   791 LILLQDALDKS--------------------TAKINIYRRQLSEQ----EGVSQQTTTRVRRFQR 831
            :..:|:..:.|                    .:::.:..|.|.|:    :.|.::...:|:...:
Human  1279 IDKIQEMQEASDHLKKQFETESEVKCNFRQEASRLTLENRDLEEELDMKDRVIKKLQDQVKTLSK 1343

  Fly   832 ELEAAED-----------------RADTAESSLNIIRAKHRTFVTTSTVPGSQVYI 870
            .:..|.|                 |.|.|:...|:|.......|..:.:||...:|
Human  1344 TIGKANDVHSSSGPKEYLGMLQYKREDEAKLIQNLILDLKPRGVVVNMIPGLPAHI 1399

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PrmNP_523982.2 Myosin_tail_1 <34..853 CDD:279860 163/882 (18%)
MYO5CNP_061198.2 Myosin_N 12..48 CDD:280832
MYSc 62..752 CDD:214580 19/110 (17%)
MYSc_Myo5 81..741 CDD:276831 17/93 (18%)
Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782 632..654
IQ 810..828 CDD:197470 4/17 (24%)
COG1340 890..1150 CDD:224259 79/380 (21%)
P-loop_NTPase <910..>1163 CDD:304359 78/373 (21%)
GBP_C <927..1030 CDD:303769 32/189 (17%)
coiled coil 997..1010 CDD:293879 5/17 (29%)
coiled coil 1019..1030 CDD:293879 2/10 (20%)
Rab5-bind 1020..1345 CDD:286404 77/373 (21%)
DUF3585 1160..1326 CDD:304905 35/180 (19%)
Myo5c_CBD 1369..1736 CDD:271260 8/31 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.