DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prm and myo18ab

DIOPT Version :9

Sequence 1:	NP_523982.2	Gene:	Prm / 39002	FlyBaseID:	FBgn0003149	Length:	879	Species:	Drosophila melanogaster
Sequence 2:	XP_021322097.1	Gene:	myo18ab / 559005	ZFINID:	ZDB-GENE-080423-1	Length:	2267	Species:	Danio rerio

Alignment Length:	865	Identity:	184/865 - (21%)
Similarity:	388/865 - (44%)	Gaps:	141/865 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 LSRLEDKIRLLQDDLEVERELRQRIEREKADLSVQVIQMSERLEEAEGGAEHQFEANR----KRD 97
            |::...:..::.|:.....||.:.:|.||:...:.:.::..|     .|...:.|.||    :|:
Zfish  1327 LTKKHGRNYIVTDEKRAVEELLESLELEKSSYHMGLSRVFFR-----AGVLAKLEENRDIQTRRN 1386

  Fly    98 AEL-------------LKLRKLLEDVHLESEETTLLLKKKHN-------EIITDFQEQVEI-LTK 141
            ..|             .|.|| ::|:.:...:..  :||...       ::.|..:..:|: ||:
Zfish  1387 LTLFQAACRGYLARQAFKKRK-IQDLAIRCIQKN--IKKNRGVKGWPWWKLFTTVRPLIEVQLTE 1448

  Fly   142 NKARAEKDKAKFQTEVYELLSQIESYNKEKIVSEKHISKLEVSISELNVKIEELNRTVIDISSHR 206
            .:.|. ||:     |:..|.|::|...||:.....:..:||..|:||:.::.:...|....|...
Zfish  1449 EQIRG-KDE-----EIQLLKSKLEKVEKERNELRLNSDRLESKITELSSELADERNTGESASQLL 1507

  Fly   207 SRLSQENIELTKDVQDLKVQLDTVSFSKSQVISQLEDAR--------RRLEDED---RRRSLLES 260
            ...:.|.:.|.||::||:.:.|.:......:..::.:||        ..::|:|   ..|...|.
Zfish  1508 ESETSERLRLEKDMKDLQAKFDAMKKQTESMEMEVMEARLIRASELNGEMDDDDTGGEWRLKYER 1572

  Fly   261 SLHQVEI-------ELDSVRNQLEEESEARIDLERQLVKANADATSWQNKWNSEVAARAEEVEEI 318
            ::.::|.       |.|   ::||.|.:.:..|||:|....||        |.||...|   :::
Zfish  1573 AIREIEFTKKRLQQEFD---DKLEVEQQNKRQLERKLTDLQAD--------NEEVQRVA---QQL 1623

  Fly   319 RRKYQVRITELEE---HIESLIVKVNNLEKMKTRLASEVEVLIIDLEKSNNSCRELTKSVNTLEK 380
            ::|.|....||::   |:|....:.::|||.:.:..||......::::..:...:|::..:.|..
Zfish  1624 KKKCQRLTAELQDTKLHLEGQQSRNHDLEKKQRKFDSEQTQAQEEVQREKSQREKLSREKDMLTG 1688

  Fly   381 HNVELKSRLDETIILYETSQRDLKNKHADLVRTVHELDKVKDNNNQLTRENKKLGDDLHEAKGAI 445
            ....|:.:|::         :||            |:..|.....|:..|.:.|.....:.:.::
Zfish  1689 EVFSLRQQLED---------KDL------------EICAVNLKLEQMEAELQDLNSQESKDEASL 1732

  Fly   446 NELNRRLHELELELRRLENERDELTAAYKEAEAGR-KAEEQRGQRLAADFNQYRHDAERRLAEKD 509
            .::.::|.:||.:::..|.|.||        :||. :..||...||..:..:.|....:.:..|:
Zfish  1733 AKIKKQLRDLEAKVKDQEEELDE--------QAGTIQMLEQAKLRLEMEMERLRQTHSKEIESKE 1789

  Fly   510 EEIEAIRKQTSIEIEQLNARVIEAETRLKTEVTRIKKKLQIQITELEMSLDVANKTNIDLQKVIK 574
            :|:|.||:..|.:::|:..: :|.|...|.:|.|.|:.::.::...:   |..:..:::.:|.::
Zfish  1790 DEVEEIRQSCSKKLKQMEVQ-LEEEYEDKQKVLREKRDMEAKLMSAQ---DQVSHRDVEAEKRLR 1850

  Fly   575 KQSLQLTELQAHYEDVQRQLQATLDQYAVAQRRLAGLNGELEEVRSHLDSANRAKRTVELQYEEA 639
            |   .|...:|...|.|..|. .|...|.::|.:|.|..:|||......:|.:|::::|::.|:.
Zfish  1851 K---DLKRTKALLADAQIMLD-HLKNNAPSKREIAQLKNQLEESEFTCAAAVKARKSMEVEIEDL 1911

  Fly   640 ASRINELTTANVSLVSIKSKLEQELSVVASDYEEVSKELRISDERYQKVQVELKHVVEQVHEEQE 704
            ..::::::.:..:|....|:|::|.:.:.|..||..:::....::::....:....:.|:.:.|.
Zfish  1912 HVQMDDISKSKQALEEQLSRLQREKNDLQSRMEEDQEDMNELMKKHKAAVAQSSQNLAQISDLQA 1976

  Fly   705 RIVKLETIKKSLEVEVKNLSIRLEEVELNAVAGSKRIISKLEARIRDLELELEEEKRRHAETIKI 769
            ::.:....|:.::.::..|..:||..|.:.|  .|.::|:.||:||:||.:||.||.:    :|.
Zfish  1977 QLEEAMKEKQDVQEKLTALQSQLEFQEQSMV--DKSLVSRQEAKIRELETKLEFEKTQ----VKR 2035

  Fly   770 LRKKERTVKEVLVQCEEDQKNLILLQDALDKSTAKINIYRRQLSEQEGVSQQTTTRVRRFQRELE 834
            |......:||.|.:..|:                     |.|.|..|...::...|:.|..|:::
Zfish  2036 LESLVARLKENLEKLTEE---------------------RDQRSASENREKEQNKRLLRQIRDIK 2079

  Fly   835 AAEDRADTAESSLNIIRAKH 854
              |:.|:.|:......|.||
Zfish  2080 --EEMAELAKKEAEASRKKH 2097

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prm	NP_523982.2	Myosin_tail_1	<34..853	CDD:279860	182/862 (21%)
myo18ab	XP_021322097.1	Atrophin-1	14..>529	CDD:331285
		Myosin_head	554..2053	CDD:332202	170/796 (21%)
		MYSc_Myo18	629..1368	CDD:276837	7/40 (18%)
		SMC_N	<1939..>2169	CDD:330553	42/188 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900