DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prm and myh10

DIOPT Version :9

Sequence 1:	NP_523982.2	Gene:	Prm / 39002	FlyBaseID:	FBgn0003149	Length:	879	Species:	Drosophila melanogaster
Sequence 2:	XP_009300420.1	Gene:	myh10 / 555454	ZFINID:	ZDB-GENE-030616-162	Length:	2014	Species:	Danio rerio

Alignment Length:	850	Identity:	220/850 - (25%)
Similarity:	424/850 - (49%)	Gaps:	58/850 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 LSSLSRLEDKIRLLQDDLEVERELRQRIEREKADLSVQVIQMSERLEEAEGGAEHQFEANRKRDA 98
            |..|..|:.::..||:|||.|:..|.:.|:.|.|||.::..:...||:.......|.|...||:.
Zfish  1151 LKQLRELQAQLAELQEDLESEKAARNKAEKLKRDLSEELEALKTELEDTLDTTAAQQELRSKREQ 1215

  Fly    99 ELLKLRKLLEDVHLESEETTLLLKKKHNEIITDFQEQVEILTKNKARAEKDKAKFQTEVYELLSQ 163
            |:.:|:|.::|.....|.....::::|...:.:..||:|...:.|...||:|...:::..||.::
Zfish  1216 EVAELKKAIDDETRNHESQIQEMRQRHGTALEEISEQLEQAKRVKGNLEKNKQTLESDNKELTNE 1280

  Fly   164 IESYNKEKIVSEKHISKLEVSISELNVKIEELNRTVIDISSHRSRLSQE--------------NI 214
            ::|..:.|..||....|||..:.|:..:..|..:...:::....::..|              .|
Zfish  1281 VKSLQQAKSESEHKRKKLEAQLQEVMARFSEGEKVKGELADRTHKIQTELDNVSCLLEDAEKKGI 1345

  Fly   215 ELTKDVQDLKVQLDTVSFSKSQVISQLEDARRRLEDEDRRRSLLESSLHQVEIELDSVRNQLEEE 279
            :|||||..|:              |||:|.:..|::|.|::..|.|.:.|:|.|.:::..|.|||
Zfish  1346 KLTKDVSSLE--------------SQLQDTQELLQEETRQKLNLSSRIRQLEEEKNNLLEQQEEE 1396

  Fly   280 SEARIDLERQLVKANADATSWQNKWNSEVAARAEEVEEIRRKYQVRITELEEHIESLIVKVNNLE 344
            .|:|.:||:||....|.....:.|...:|.| .|.:||::||.|..:....:.:|...:..:.||
Zfish  1397 EESRKNLEKQLATLQAQLVETKKKLEDDVGA-LEGLEEVKRKLQKDMEVTSQKLEEKAIAFDKLE 1460

  Fly   345 KMKTRLASEVEVLIIDLEKSNNSCRELTKSVNTLEKHNVELKSRL--DETIILYETSQRD----- 402
            |.|.||..|::.|::||:..    |::   |:.|||...:....|  ::||......:||
Zfish  1461 KTKNRLQQELDDLMVDLDHQ----RQI---VSNLEKKQKKFDQMLAEEKTISARYAEERDRAEAE 1518

  Fly   403 LKNKHADLVRTVHELDKVKDNNNQLTRENKKLGDDLHEAKGAINELNRRLHELELELRRLENERD 467
            .:.|....:.....||:..:...:..|.||:|..::.:...:.:::.:.:||||...|.||.:.:
Zfish  1519 AREKDTKALSMARALDEALEAKEEFERLNKQLRAEMEDLISSKDDVGKNVHELEKSKRTLEQQVE 1583

  Fly   468 ELTAAYKEAEAGRKAEEQRGQRLAADFNQYRHDAERRLAEKDEEIEAIRKQTSIEIEQLNARVIE 532
            |:....:|.|...:|.|....||..:....:...:|.|..:||:.|..::....::.::.|. :|
Zfish  1584 EMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFDRDLQARDEQNEEKKRALVKQVREMEAE-LE 1647

  Fly   533 AETRLKTEVTRIKKKLQIQITELEMSLDVANKTNIDLQKVIKKQSLQLTELQAHYEDVQRQLQAT 597
            .|.:.:......||||::.:.::|..::.|||..   .:.||    ||.:|||..:|.||:|:..
Zfish  1648 DERKQRALAVAAKKKLEMDLKDVEAQIEAANKAR---DEAIK----QLRKLQAQMKDYQRELEEA 1705

  Fly   598 -------LDQYAVAQRRLAGLNGELEEVRSHLDSANRAKRTVELQYEEAASRINELTTANVSLVS 655
                   ..|....:::|..|..|:.:::..|.|:.||:|..|.:.:|.|..|:...:...:|:.
Zfish  1706 RTSRDEIFTQSKENEKKLKSLEAEILQLQEDLASSERARRHAEQERDELADEISNSASGKAALLD 1770

  Fly   656 IKSKLEQELSVVASDYEEVSKELRISDERYQKVQVELKHVVEQVHEEQERIVKLETIKKSLEVEV 720
            .|.:||..::.:..:.||....:.:.::|::|..:::..:..::..|:....|.|..::.||.:.
Zfish  1771 EKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTMQVDTLNTELAGERSAAQKSENARQQLERQN 1835

  Fly   721 KNLSIRLEEVELNAVAGSKRIISKLEARIRDLELELEEEKRRHAETIKILRKKERTVKEVLVQCE 785
            |:|..:|:|:|.:..:..|..|:.|||:|..||.:||:|.:..|...||:|:.|:.:|||.:|.|
Zfish  1836 KDLKSKLQELEGSVKSKFKASIAALEAKILQLEEQLEQEAKERAAANKIVRRTEKKLKEVFMQVE 1900

  Fly   786 EDQKNLILLQDALDKSTAKINIYRRQLSEQEGVSQQTTTRVRRFQRELEAAEDRADTAESSLNII 850
            :::::....::.::|:.:::...:|||.|.|..:.:.....|:.||||:.|.:.::.....:|.:
Zfish  1901 DERRHADQYKEQMEKANSRMKQLKRQLEEAEEEATRANASRRKLQRELDDATEASEGLSREVNTL 1965

  Fly   851 RAKHR 855
            :.:.|
Zfish  1966 KNRLR 1970

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prm	NP_523982.2	Myosin_tail_1	<34..853	CDD:279860	219/846 (26%)
myh10	XP_009300420.1	Myosin_N	37..75	CDD:280832
		Myosin_head	90..812	CDD:278492
		MYSc_Myh10	102..812	CDD:276952
		Myosin_tail_1	889..1969	CDD:279860	219/847 (26%)
		DUF342	<1085..1170	CDD:302792	7/18 (39%)
		RILP-like	<1528..1637	CDD:304877	25/108 (23%)
		GBP_C	<1641..1734	CDD:303769	26/100 (26%)
		coiled coil	1705..1714	CDD:293879	0/8 (0%)
		coiled coil	1723..1734	CDD:293879	3/10 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810