DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Prm and MYO5B

DIOPT Version :9

Sequence 1:NP_523982.2 Gene:Prm / 39002 FlyBaseID:FBgn0003149 Length:879 Species:Drosophila melanogaster
Sequence 2:NP_001073936.1 Gene:MYO5B / 4645 HGNCID:7603 Length:1848 Species:Homo sapiens


Alignment Length:941 Identity:194/941 - (20%)
Similarity:375/941 - (39%) Gaps:277/941 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 RLLQDDLEVERELRQRIEREKAD-----LSVQVIQMSERLEEAEGGAEHQFEANRKRDAELLK-- 102
            ||....|.::|..|..:.|..|:     .:..|:|...|::.|     .|.....:|.|.:::  
Human   786 RLKGATLTLQRYCRGHLARRLAEHLRRIRAAVVLQKHYRMQRA-----RQAYQRVRRAAVVIQAF 845

  Fly   103 -----LRKLLEDVHLESEETTL------LLKKKHNEIITDFQEQVE-----ILTKNKARAEKDKA 151
                 :|:....|.:|.:.||:      .:.::|.:.:.|....::     :..:.:.:|.:.:|
Human   846 TRAMFVRRTYRQVLMEHKATTIQKHVRGWMARRHFQRLRDAAIVIQCAFRMLKARRELKALRIEA 910

  Fly   152 K-----------FQTEVYELLSQIESYNKE-KIVSEKHISKLEVSISELNVKIEELNRTVIDISS 204
            :           .:.:|.:|..:|:..||| |.:||    :|.|:.|...:::|.|.:.::..  
Human   911 RSAEHLKRLNVGMENKVVQLQRKIDEQNKEFKTLSE----QLSVTTSTYTMEVERLKKELVHY-- 969

  Fly   205 HRSRLSQENIELTKDVQDLKVQLDTVSFSKSQVISQLEDARRRLEDEDRRR-SLLESSLHQVEIE 268
            .:|.....::.|.::|:.|:.:|.. :.|:.::   ||||..|.:||.|:| :.||.....::.|
Human   970 QQSPGEDTSLRLQEEVESLRTELQR-AHSERKI---LEDAHSREKDELRKRVADLEQENALLKDE 1030

  Fly   269 LDSVRNQL---EEESEARIDLERQLVKANADATSWQNKWNSEVAARAEEVEEIRRKYQVRITE-- 328
            .:.:.||:   .::..|:..::..|:|                    :|:||.|.:||..:.|  
Human  1031 KEQLNNQILCQSKDEFAQNSVKENLMK--------------------KELEEERSRYQNLVKEYS 1075

  Fly   329 -LEEHIESL-----IVKV-----------------NNLEKMKTRLASEVE-----VLIIDLEKSN 365
             ||:..::|     |:|.                 :|...:.|....:.|     |..|.|||:.
Human  1076 QLEQRYDNLRDEMTIIKQTPGHRRNPSNQSSLESDSNYPSISTSEIGDTEDALQQVEEIGLEKAA 1140

  Fly   366 NSCR---ELTKSVNTLEKHNVELKSRLDETIILYETSQRDLKNKHADLVRTVHELDKVKD----- 422
            ....   :|.|.|..||:...:|:.:|:      :..|:|.|...|:..:|..:||...|     
Human  1141 MDMTVFLKLQKRVRELEQERKKLQVQLE------KREQQDSKKVQAEPPQTDIDLDPNADLAYNS 1199

  Fly   423 -NNNQLTRENKKLGDDLHEAKGAI---------------------NELNRRLHELELELRRLE-- 463
             ...:|..|||||.:||:|.:.|:                     |:| :..|| |||:|:.|  
Human  1200 LKRQELESENKKLKNDLNELRKAVADQATQNNSSHGSPDSYSLLLNQL-KLAHE-ELEVRKEEVL 1262

  Fly   464 NERDELTAAYKEAEAGRKAEEQRGQRLAADFNQYRHDAERRLAEKDEEIEAIRK--QTSIEIEQ- 525
            ..|.::.:|.:...|||.||.....|.:.. |..:|      .::::.|||...  ||:.:.|. 
Human  1263 ILRTQIVSADQRRLAGRNAEPNINARSSWP-NSEKH------VDQEDAIEAYHGVCQTNSKTEDW 1320

  Fly   526 --LN---------------ARVIEAETRLKT-----EVTRIKKKLQIQITELEMSLDVANKTNID 568
              ||               ||::||:.:.::     ||..:|.:|:            |.|..:|
Human  1321 GYLNEDGELGLAYQGLKQVARLLEAQLQAQSLEHEEEVEHLKAQLE------------ALKEEMD 1373

  Fly   569 LQKVIKKQSLQLT-ELQAHYEDVQRQLQATLDQYAVAQRRLAGLNGELEEVRSHLDSANR-AKRT 631
            .|:....|:|.|: |.|..: .||:::.           ||...|.:|:|:...|:...| .|:.
Human  1374 KQQQTFCQTLLLSPEAQVEF-GVQQEIS-----------RLTNENLDLKELVEKLEKNERKLKKQ 1426

  Fly   632 VELQYEEAASRINELTTANVSLVSIKSKLEQELSVVASDYEEVSKELRISDERYQKVQVELKHVV 696
            :::..::|    .:|..|            |.|:.......|:::::.:     |:.:.:.:.::
Human  1427 LKIYMKKA----QDLEAA------------QALAQSERKRHELNRQVTV-----QRKEKDFQGML 1470

  Fly   697 EQVHEEQERIVKLETIKKSLEVEVK--------------------------NLSIRLEEVELNAV 735
            | .|:|.|.:     :.::|..::|                          |..:::..:..:.:
Human  1471 E-YHKEDEAL-----LIRNLVTDLKPQMLSGTVPCLPAYILYMCIRHADYTNDDLKVHSLLTSTI 1529

  Fly   736 AGSKRIISKLEARIRDLELELEEEKRRHAETIKILR-----------KKERTVKEVLVQCEEDQK 789
            .|.|:::.|...       :.|......:.|.::|.           ..:.|.|    |.|...|
Human  1530 NGIKKVLKKHND-------DFEMTSFWLSNTCRLLHCLKQYSGDEGFMTQNTAK----QNEHCLK 1583

  Fly   790 NLILLQDALDKSTAKINIYRRQLSEQEGVSQ 820
            |..|.:.....|...|.||::.:...|||.|
Human  1584 NFDLTEYRQVLSDLSIQIYQQLIKIAEGVLQ 1614

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PrmNP_523982.2 Myosin_tail_1 <34..853 CDD:279860 194/941 (21%)
MYO5BNP_001073936.1 Requires for interaction with LIMA1. /evidence=ECO:0000269|PubMed:29880681 21..40
MYSc 64..760 CDD:214580
MYSc_Myo5 83..749 CDD:276831
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 596..630
Actin-binding. /evidence=ECO:0000255 640..662
IQ 860..881 CDD:197470 4/20 (20%)
CCDC144C 895..1172 CDD:291576 66/312 (21%)
RILP-like <980..1080 CDD:304877 31/123 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1093..1123 2/29 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1166..1192 8/31 (26%)
Myo5b_CBD 1474..1845 CDD:271261 26/157 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.