DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prm and MYO5A

DIOPT Version :9

Sequence 1:	NP_523982.2	Gene:	Prm / 39002	FlyBaseID:	FBgn0003149	Length:	879	Species:	Drosophila melanogaster
Sequence 2:	NP_001369277.1	Gene:	MYO5A / 4644	HGNCID:	7602	Length:	1904	Species:	Homo sapiens

Alignment Length:	1046	Identity:	234/1046 - (22%)
Similarity:	392/1046 - (37%)	Gaps:	329/1046 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 LEDKIRLLQDDLEVERELRQRIEREKADLSVQVIQMSERLEEAEGGAEHQFEANRKRDAELLKLR 104
            :|:||          .:|:::::.:..|....|    |:|...||          ..::|..|||
Human   949 MENKI----------MQLQRKVDEQNKDYKCLV----EKLTNLEG----------IYNSETEKLR 989

  Fly   105 KLLEDVHLESEETTLLLKKKHNEIITDFQEQVEILTKN--KARAEK-------DKAKFQTEVYEL 160
            ..||.:.|..||..:...:     :...||::..|.|:  :.|:||       |:.|.:||  :|
Human   990 SDLERLQLSEEEAKVATGR-----VLSLQEEIAKLRKDLEQTRSEKKCIEEHADRYKQETE--QL 1047

  Fly   161 LSQIESYN----KEKIVSEKHISKLEVSISELNVK--IEELNRTVIDISSHRSR---LSQENIEL 216
            :|.::..|    :||......|.:....::|...|  :||..:..:|::..|.|   |..|...|
Human  1048 VSNLKEENTLLKQEKEALNHRIVQQAKEMTETMEKKLVEETKQLELDLNDERLRYQNLLNEFSRL 1112

  Fly   217 TKDVQDLKVQL---------------DTVSFSKSQV-----ISQLEDARRRLEDEDRRRSLLESS 261
            .:...|||.::               .|.|.::|:.     |:::||...|.|:...::..|:.|
Human  1113 EERYDDLKEEMTLMVHVPKPGHKRTDSTHSSNESEYIFSSEIAEMEDIPSRTEEPSEKKVPLDMS 1177

  Fly   262 LHQVEIELDSVRNQLEEESEARID-LERQLVKANADATSWQNKWNSEVAARAEEVEEIRRKYQVR 325
            |.   ::|.....:||:|.:...| |:|:                .|...|::..||.|.  |:|
Human  1178 LF---LKLQKRVTELEQEKQVMQDELDRK----------------EEQVLRSKAKEEERP--QIR 1221

  Fly   326 ITELEEHIESLIVKVNNLEKMKTRLASEVEVLIIDLEK--SNNSCRELTKS--------VNTLEK 380
            ..|||  .|||  |...||....:|.:|:.    :|.|  |..|..|:|..        :..|..
Human  1222 GAELE--YESL--KRQELESENKKLKNELN----ELRKALSEKSAPEVTAPGAPAYRVLMEQLTS 1278

  Fly   381 HNVELKSRLDETIILYE--TSQ------RDLKNKHADLVRTVHELDKVKDNNN------QLTREN 431
            .:.||..|.:|.:||..  .||      :|.||...|....:.::.|:||...      .|...|
Human  1279 VSEELDVRKEEVLILRSQLVSQKEAIQPKDDKNTMTDSTILLEDVQKMKDKGEIAQAYIGLKETN 1343

  Fly   432 KKLGDDLHEAK---------GAINELNRRLH-ELELELRRLENERDELTAAYKEAEAGRKAEEQR 486
            :....|.||..         ..:.:.||.|. :|:.:.|..|||.:.|....:..    |.|..|
Human  1344 RSSALDYHELNEDGELWLVYEGLKQANRLLESQLQSQKRSHENEAEALRGEIQSL----KEENNR 1404

  Fly   487 GQRLAADFNQYRHDAE---------RRLAEKD---EEIEA--IRKQTSIEIEQLNARVIEAETRL 537
            .|:|.|...|...:|.         .||..::   ||:.|  .:|..|..| .|..|:|:...:|
Human  1405 QQQLLAQNLQLPPEARIEASLQHEITRLTNENLYFEELYADDPKKYQSYRI-SLYKRMIDLMEQL 1468

  Fly   538 KTE---VTRIKKKLQI---QITELEMSLDVANKTNIDLQKVI-----------KKQSLQLTELQA 585
            :.:   |.::||:|::   :|.|||    |....||...::|           |::..| ..|:.
Human  1469 EKQDKTVRKLKKQLKVFAKKIGELE----VGQMENISPGQIIDEPIRPVNIPRKEKDFQ-GMLEY 1528

  Fly   586 HYEDVQ---RQLQATLDQYAVAQRRLAGLNGEL--------------EEVRSHLDSA-NRAKRTV 632
            ..||.|   :.|...|....||...:.||...:              ::|||.|.|. |..|:.:
Human  1529 KKEDEQKLVKNLILELKPRGVAVNLIPGLPAYILFMCVRHADYLNDDQKVRSLLTSTINSIKKVL 1593

  Fly   633 E-----------------------LQY--EEA-----ASRINELTTANVSLVSIKSKLEQELSVV 667
            :                       .||  ||.     .||.||....|..|
Human  1594 KKRGDDFETVSFWLSNTCRFLHCLKQYSGEEGFMKHNTSRQNEHCLTNFDL-------------- 1644

  Fly   668 ASDYEEVSKELRISDERYQKVQVELKHVVEQV-------HE--------------------EQER 705
             ::|.:|..:|.|  :.||::...|:::::.:       ||                    ..|.
Human  1645 -AEYRQVLSDLAI--QIYQQLVRVLENILQPMIVSGMLEHETIQGVSGVKPTGLRKRTSSIADEG 1706

  Fly   706 IVKLETIKKSLE-----------------------------VEVKNLSIRLEEVELNAVAGSKRI 741
            ...|::|.:.|.                             :.:.||.:|.:....:.....:..
Human  1707 TYTLDSILRQLNSFHSVMCQHGMDPELIKQVVKQMFYIIGAITLNNLLLRKDMCSWSKGMQIRYN 1771

  Fly   742 ISKLEARIRDLELELEEEKRRHAETI-------KILRKKERTVKEVLVQCEEDQKNLILLQDALD 799
            :|:||..:||..|.....|    ||:       ::|:.|::|        ::|.:.:..:.:||
Human  1772 VSQLEEWLRDKNLMNSGAK----ETLEPLIQAAQLLQVKKKT--------DDDAEAICSMCNAL- 1823

  Fly   800 KSTAKI----NIYRRQLSEQEGVSQQTTTRVRRFQRELEAAEDRADTAESSLNIIRAKHRTFVTT 860
             :||:|    |:|......:|.||   .:.:|..|..|   .||.|:.:.   ::.|||...||.
Human  1824 -TTAQIVKVLNLYTPVNEFEERVS---VSFIRTIQMRL---RDRKDSPQL---LMDAKHIFPVTF 1878

  Fly   861 STVPGS 866
            ...|.|
Human  1879 PFNPSS 1884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prm	NP_523982.2	Myosin_tail_1	<34..853	CDD:279860	227/1031 (22%)
MYO5A	NP_001369277.1	COG5022	35..1472	CDD:227355	141/587 (24%)
		MYSc_Myo5	107..775	CDD:276831
		Myo5a_CBD	1530..1904	CDD:271262	78/395 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910