Protein Alignment Prm and MYH11

DIOPT Version :10

• Sequence 1: NP_523982.2
• Gene: Prm / 39002
• FlyBaseID: FBgn0003149
• Length: 879
• Species: Drosophila melanogaster
• Sequence 2: NP_001035203.1
• Gene: MYH11 / 4629
• HGNCID: 7569
• Length: 1979
• Species: Homo sapiens
• Alignment Length: 870
• Identity: 231/870 - (26%)
• Similarity: 422/870 - (48%)
• Gaps: 80/870 - (9%)

  Fly    34 LSSLSRLEDKIRLLQDDLEVERELRQRIEREKADLSVQVIQMSERLEEAEGGAEHQFEANRKRDA 98
            |..:..||..|..||:||:.||..|.:.|::|.||..::..:...||:.......|.|...||:.
Human  1117 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQ 1181

  Fly    99 ELLKLRKLLEDVHLESEETTLLLKKKHNEIITDFQEQVEILTKNKARAEKDKAKFQTEVYELLSQ 163
            |:..|:|.|::.....|.....:::||.:.:.:..||:|...:.||..:|:|...:.|..:|..:
Human  1182 EVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1246

  Fly   164 IESYNKEKIVSEKHISKLEVSI--------------SELNVKIEELNRTVIDISSHRSRLSQENI 214
            :....:.|...|....|||..:              :|||.|:.:|...|..::...:....:.|
Human  1247 LRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1311

  Fly   215 ELTKDVQDLKVQLDTVSFSKSQVISQLEDARRRLEDEDRRRSLLESSLHQVEIELDSVRNQLEEE 279
            :|.|||..|.              |||:|.:..|::|.|::..:.:.|.|:|.|.:|:::||:||
Human  1312 KLAKDVASLS--------------SQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE 1362

  Fly   280 SEARIDLERQLVKANADATSWQNKWNSEVAARAEEVEEIRRKYQVRITELEEHIESLIVKVNNLE 344
            .||:.:|||.:...|...:..:.|. .:.|:..|.:||.::::|..|..|.:..|......:.||
Human  1363 MEAKQNLERHISTLNIQLSDSKKKL-QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE 1426

  Fly   345 KMKTRLASEVEVLIIDLEKSNNSCRELTKSVNTLEKHNVELKSRLDETIILYETSQRDLKNKHAD 409
            |.|.||..|::.|::||:..    |:|..        |:|.|.|..:.::   ..::::.:|:||
Human  1427 KTKNRLQQELDDLVVDLDNQ----RQLVS--------NLEKKQRKFDQLL---AEEKNISSKYAD 1476

  Fly   410 ------------------LVRTVHELDKVKDNNNQLTRENKKLGDDLHEAKGAINELNRRLHELE 456
                              |.|.:.|..:.|:   :|.|.||.|..::.:...:.:::.:.:||||
Human  1477 ERDRAEAEAREKETKALSLARALEEALEAKE---ELERTNKMLKAEMEDLVSSKDDVGKNVHELE 1538

  Fly   457 LELRRLENERDELTAAYKEAEAGRKAEEQRGQRLAADFNQYRHDAERRLAEKDEEIEAIRKQTSI 521
            ...|.||.:.:|:....:|.|...:|.|....||..:....:...||.|..:||:.|..|:|...
Human  1539 KSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR 1603

  Fly   522 EIEQLNARVIEAETRLKTEVTRIKKKLQIQITELEMSLDVANKTNIDLQKVIKKQSLQLTELQAH 586
            ::.:.... :|.|.:.:......||||:..:.:||:..|.|.|..   ::.||    ||.:|||.
Human  1604 QLHEYETE-LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGR---EEAIK----QLRKLQAQ 1660

  Fly   587 YEDVQRQLQ---ATLDQ-YAVA---QRRLAGLNGELEEVRSHLDSANRAKRTVELQYEEAASRIN 644
            .:|.||:|:   |:.|: :|.|   :::...|..:|.:::..|.:|.||::..:|:.||.|..:.
Human  1661 MKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1725

  Fly   645 ELTTANVSLVSIKSKLEQELSVVASDYEEVSKELRISDERYQKVQVELKHVVEQVHEEQERIVKL 709
            ...:...:|...|.:||..::.:..:.||....:....:|.:|...:.:.:..::..|:....|.
Human  1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1790

  Fly   710 ETIKKSLEVEVKNLSIRLEEVELNAVAGSKRIISKLEARIRDLELELEEEKRRHAETIKILRKKE 774
            |:.::.||.:.|.|..:|.|:|....:..|..|:.|||:|..||.::|:|.|......|.|::|:
Human  1791 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKD 1855

  Fly   775 RTVKEVLVQCEEDQKNLILLQDALDKSTAKINIYRRQLSEQEGVSQQTTTRVRRFQRELEAAEDR 839
            :.:||:|:|.|:::|.....::..:|..|::...:|||.|.|..||:.....|:.||||:.|.:.
Human  1856 KKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1920

  Fly   840 ADTAESSLNIIRAKHRTFVTTSTVP 864
            .:.....:|.:::|.|....||.||
Human  1921 NEAMGREVNALKSKLRRGNETSFVP 1945

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prm	NP_523982.2	Myosin_tail_1	<34..853	CDD:460256	225/857 (26%)
MYH11	NP_001035203.1	Myosin_N	31..76	CDD:460670
		MYSc_class_II	99..778	CDD:276951
		Actin-binding. /evidence=ECO:0000250	668..690
		Actin-binding. /evidence=ECO:0000250	769..783
		Myosin_tail_1	855..1935	CDD:460256	225/858 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	865..889
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1751..1807		11/55 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1873..1979		22/73 (30%)
		C-terminal	1942..1979		3/4 (75%)