DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prm and MYH9

DIOPT Version :9

Sequence 1:	NP_523982.2	Gene:	Prm / 39002	FlyBaseID:	FBgn0003149	Length:	879	Species:	Drosophila melanogaster
Sequence 2:	NP_002464.1	Gene:	MYH9 / 4627	HGNCID:	7579	Length:	1960	Species:	Homo sapiens

Alignment Length:	848	Identity:	238/848 - (28%)
Similarity:	415/848 - (48%)	Gaps:	54/848 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 LSSLSRLEDKIRLLQDDLEVERELRQRIEREKADLSVQVIQMSERLEEAEGGAEHQFEANRKRDA 98
            |..:..||.:|..||:|||.||..|.:.|::|.||..::..:...||:.......|.|...||:.
Human  1103 LKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQ 1167

  Fly    99 ELLKLRKLLEDVHLESEETTLLLKKKHNEIITDFQEQVEILTKNKARAEKDKAKFQTEVYELLSQ 163
            |:..|:|.||:.....|.....:::||::.:.:..||:|...:.||..||.|...:.|..||.::
Human  1168 EVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANE 1232

  Fly   164 IESYNKEKIVSEKHISKLEVSISELNVKIEELNRTVIDISSHRSRLSQENIELTKDVQDLKVQLD 228
            ::...:.|..||....|:|..:.||.||..|..|.              ..||...|..|:|:||
Human  1233 VKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERV--------------RTELADKVTKLQVELD 1283

  Fly   229 TV------SFSKSQVI--------SQLEDARRRLEDEDRRRSLLESSLHQVEIELDSVRNQLEEE 279
            .|      |.|||..:        |||:|.:..|::|:|::..|.:.|.|||.|.:|.|.|||||
Human  1284 NVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEE 1348

  Fly   280 SEARIDLERQLVKANADATSWQNKWNSEVAARAEEVEEIRRKYQVRITELEEHIESLIVKVNNLE 344
            .||:.:||:|:...:|.....:.|....|.. .|..||::||.|..:..|.:..|..:...:.||
Human  1349 EEAKHNLEKQIATLHAQVADMKKKMEDSVGC-LETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLE 1412

  Fly   345 KMKTRLASEVEVLIIDLEKSNNSCRELTKSVNTLEKHNVELKSRLDETIILYETSQRD-----LK 404
            |.||||..|::.|::||:....|...|.|.....::...|     ::||......:||     .:
Human  1413 KTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAE-----EKTISAKYAEERDRAEAEAR 1472

  Fly   405 NKHADLVRTVHELDKVKDNNNQLTRENKKLGDDLHEAKGAINELNRRLHELELELRRLENERDEL 469
            .|....:.....|::..:...:|.|.||:...::.:...:.:::.:.:||||...|.||.:.:|:
Human  1473 EKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEM 1537

  Fly   470 TAAYKEAEAGRKAEEQRGQRLAADFNQYRHDAERRLAEKDEEIEAIRKQTSIEIEQLNARVIEAE 534
            ....:|.|...:|.|....||..:....:...||.|..:||:.|..:||...::.::.|. :|.|
Human  1538 KTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAE-LEDE 1601

  Fly   535 TRLKTEVTRIKKKLQIQITELEMSLDVANKTNIDLQKVIKKQSLQLTELQAHYEDVQRQLQAT-- 597
            .:.::.....:|||::.:.:||..:|.|||..   .:.||    ||.:|||..:|..|:|..|
Human  1602 RKQRSMAVAARKKLEMDLKDLEAHIDSANKNR---DEAIK----QLRKLQAQMKDCMRELDDTRA 1659

  Fly   598 -----LDQYAVAQRRLAGLNGELEEVRSHLDSANRAKRTVELQYEEAASRINELTTANVSLVSIK 657
                 |.|....:::|..:..|:.:::..|.:|.||||..:.:.:|.|..|...:......:..|
Human  1660 SREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEK 1724

  Fly   658 SKLEQELSVVASDYEEVSKELRISDERYQKVQVELKHVVEQVHEEQERIVKLETIKKSLEVEVKN 722
            .:||..::.:..:.||......:.::|.:|..:::..:...::.|:....|.|..::.||.:.|.
Human  1725 RRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKE 1789

  Fly   723 LSIRLEEVELNAVAGSKRIISKLEARIRDLELELEEEKRRHAETIKILRKKERTVKEVLVQCEED 787
            |.::|:|:|....:..|..|:.|||:|..||.:|:.|.:......|.:|:.|:.:|:||:|.:::
Human  1790 LKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDE 1854

  Fly   788 QKNLILLQDALDKSTAKINIYRRQLSEQEGVSQQTTTRVRRFQRELEAAEDRADTAESSLNIIRA 852
            ::|....:|..||::.::...:|||.|.|..:|:.....|:.|||||.|.:.||.....::.::.
Human  1855 RRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKN 1919

  Fly   853 KHR 855
            |.|
Human  1920 KLR 1922

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prm	NP_523982.2	Myosin_tail_1	<34..853	CDD:279860	236/844 (28%)
MYH9	NP_002464.1	Mediates interaction with LIMCH1. /evidence=ECO:0000269\|PubMed:28228547	2..838
		Myosin_N	29..68	CDD:367160
		Motor_domain	95..764	CDD:354959
		Actin-binding	654..676
		Myosin_tail_1	841..1921	CDD:366712	236/845 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1035..1057
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1118..1137		8/18 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1877..1960		17/46 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810