DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Prm and MYH8

DIOPT Version :9

Sequence 1:NP_523982.2 Gene:Prm / 39002 FlyBaseID:FBgn0003149 Length:879 Species:Drosophila melanogaster
Sequence 2:NP_002463.2 Gene:MYH8 / 4626 HGNCID:7578 Length:1937 Species:Homo sapiens


Alignment Length:825 Identity:297/825 - (36%)
Similarity:493/825 - (59%) Gaps:1/825 - (0%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 IQDLSSLSRLEDKIRLLQDDLEVERELRQRIEREKADLSVQVIQMSERLEEAEGGAEHQFEANRK 95
            ||....:..|:.:|..|.:::|.||..|.:.|::::|||.::.::|||||||.|....|.|.|:|
Human  1105 IQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKK 1169

  Fly    96 RDAELLKLRKLLEDVHLESEETTLLLKKKHNEIITDFQEQVEILTKNKARAEKDKAKFQTEVYEL 160
            |:||..|||:.||:..|:.|.....|:|||.:.:.:..||::.|.:.|.:.||:|::.:.|..:|
Human  1170 REAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDL 1234

  Fly   161 LSQIESYNKEKIVSEKHISKLEVSISELNVKIEELNRTVIDISSHRSRLSQENIELTKDVQDLKV 225
            .|..|:.:|.|...||....||..:|||..|.||..|.:.|:::.|:||..|..|.::.:.:...
Human  1235 SSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDA 1299

  Fly   226 QLDTVSFSKSQVISQLEDARRRLEDEDRRRSLLESSLHQVEIELDSVRNQLEEESEARIDLERQL 290
            .:..:|.||.....|:|:.:.:||:|.:.::.|..:|.....:.|.:|.|.|||.|.:.:|:|.|
Human  1300 LVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRAL 1364

  Fly   291 VKANADATSWQNKWNSEVAARAEEVEEIRRKYQVRITELEEHIESLIVKVNNLEKMKTRLASEVE 355
            .|||::...|:.|:.::...|.||:||.::|...|:.|.|||:|::..|..:|||.|.||.:|||
Human  1365 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVE 1429

  Fly   356 VLIIDLEKSNNSCRELTKSVNTLEKHNVELKSRLDETIILYETSQRDLKNKHADLVRTVHELDKV 420
            .|::|:|:||.:|..|.|.....:|...|.|.:.:||....|.||::.::...:|.:..:..::.
Human  1430 DLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEES 1494

  Fly   421 KDNNNQLTRENKKLGDDLHEAKGAINELNRRLHELELELRRLENERDELTAAYKEAEAGRKAEEQ 485
            .|....|.||||.|..::.:....|.|..:::||||...:::|.|:.|:.||.:||||..:.||.
Human  1495 LDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEG 1559

  Fly   486 RGQRLAADFNQYRHDAERRLAEKDEEIEAIRKQTSIEIEQLNARVIEAETRLKTEVTRIKKKLQI 550
            :..|:..:.||.:.:.:|::|||||||:.:::..:..:|.:.: .::||.|.:.:..|:|||::.
Human  1560 KILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQS-TLDAEIRSRNDALRVKKKMEG 1623

  Fly   551 QITELEMSLDVANKTNIDLQKVIKKQSLQLTELQAHYEDVQRQLQATLDQYAVAQRRLAGLNGEL 615
            .:.|:|:.|:.||:...:..:..:.....|.|.|.|.:|..|..:...:|.|:.:||...|..|:
Human  1624 DLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEI 1688

  Fly   616 EEVRSHLDSANRAKRTVELQYEEAASRINELTTANVSLVSIKSKLEQELSVVASDYEEVSKELRI 680
            ||:.:.|:...|:::..|.:..:|:.|:..|.|.|.||::.|.|||.::|.:.|:.|||.:|.|.
Human  1689 EELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRN 1753

  Fly   681 SDERYQKVQVELKHVVEQVHEEQERIVKLETIKKSLEVEVKNLSIRLEEVELNAVAGSKRIISKL 745
            ::|:.:|...:...:.|::.:||:....||.:||:||..||:|..||:|.|..|:.|.|:.|.||
Human  1754 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKL 1818

  Fly   746 EARIRDLELELEEEKRRHAETIKILRKKERTVKEVLVQCEEDQKNLILLQDALDKSTAKINIYRR 810
            |||:|:||.|:|.|::|:||.:|.|||.||.|||:..|.|||:||::.|||.:||..||:..|:|
Human  1819 EARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKR 1883

  Fly   811 QLSEQEGVSQQTTTRVRRFQRELEAAEDRADTAESSLNIIRAKHR 855
            |..|.|..|....::.|:.|.|||.||:|||.|||.:|.:|.|.|
Human  1884 QAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVNKLRVKSR 1928

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PrmNP_523982.2 Myosin_tail_1 <34..853 CDD:279860 293/818 (36%)
MYH8NP_002463.2 Myosin_N 38..75 CDD:280832
Myosin_head 90..769 CDD:278492
MYSc_Myh8 102..769 CDD:276882
Actin-binding 658..680
Actin-binding 760..774
Myosin_tail_1 849..1926 CDD:279860 295/821 (36%)
eIF-4B <1042..1099 CDD:283846
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1126..1146 8/19 (42%)
COG6 1375..>1510 CDD:303003 47/134 (35%)
DUF342 <1505..1581 CDD:302792 24/75 (32%)
TMPIT 1741..>1828 CDD:285135 36/86 (42%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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