Protein Alignment Prm and MYH2

DIOPT Version :10

• Sequence 1: NP_523982.2
• Gene: Prm / 39002
• FlyBaseID: FBgn0003149
• Length: 879
• Species: Drosophila melanogaster
• Sequence 2: NP_060004.3
• Gene: MYH2 / 4620
• HGNCID: 7572
• Length: 1941
• Species: Homo sapiens
• Alignment Length: 825
• Identity: 295/825 - (35%)
• Similarity: 495/825 - (60%)
• Gaps: 1/825 - (0%)

  Fly    31 IQDLSSLSRLEDKIRLLQDDLEVERELRQRIEREKADLSVQVIQMSERLEEAEGGAEHQFEANRK 95
            ||....:..|:.:|..|::::|.||..|.:.|::::|||.::.::|||||||.|....|.|.|:|
Human  1108 IQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKK 1172

  Fly    96 RDAELLKLRKLLEDVHLESEETTLLLKKKHNEIITDFQEQVEILTKNKARAEKDKAKFQTEVYEL 160
            |:||..|:|:.||:..|:.|.|...|:|||.:.:.:..||::.|.:.|.:.||:|::.:.|:.:|
Human  1173 REAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDL 1237

  Fly   161 LSQIESYNKEKIVSEKHISKLEVSISELNVKIEELNRTVIDISSHRSRLSQENIELTKDVQDLKV 225
            .|.:|:.:|.|...||....||..:|||..|.||..|.:.|:::.|.||..|:.|.::.:.:.:.
Human  1238 ASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEA 1302

  Fly   226 QLDTVSFSKSQVISQLEDARRRLEDEDRRRSLLESSLHQVEIELDSVRNQLEEESEARIDLERQL 290
            .:..:|..|.....|:|:.:|:||:|.:.::.|..:|.....:.|.:|.|.|||.|::.:|:|.|
Human  1303 LVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRAL 1367

  Fly   291 VKANADATSWQNKWNSEVAARAEEVEEIRRKYQVRITELEEHIESLIVKVNNLEKMKTRLASEVE 355
            .|||.:...|:.|:.::...|.||:||.::|...|:...|||:|::..|..:|||.|.||.:|||
Human  1368 SKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVE 1432

  Fly   356 VLIIDLEKSNNSCRELTKSVNTLEKHNVELKSRLDETIILYETSQRDLKNKHADLVRTVHELDKV 420
            .|::|:|::|.:|..|.|.....:|...|.|.:.:||....|.||::.::...:|.:..:..::.
Human  1433 DLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEES 1497

  Fly   421 KDNNNQLTRENKKLGDDLHEAKGAINELNRRLHELELELRRLENERDELTAAYKEAEAGRKAEEQ 485
            .|....|.||||.|..::.:....|.|..:|:||||...:::|.|:.||.||.:||||..:.||.
Human  1498 LDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEG 1562

  Fly   486 RGQRLAADFNQYRHDAERRLAEKDEEIEAIRKQTSIEIEQLNARVIEAETRLKTEVTRIKKKLQI 550
            :..|:..:.||.:.:.:|::|||||||:.: |:..|.|.:.....::||.|.:.:..|:|||::.
Human  1563 KILRIQLELNQVKSEVDRKIAEKDEEIDQL-KRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEG 1626

  Fly   551 QITELEMSLDVANKTNIDLQKVIKKQSLQLTELQAHYEDVQRQLQATLDQYAVAQRRLAGLNGEL 615
            .:.|:|:.|:.||:...:..:..:.....|.:.|.|.:|..|..:...:|.|:.:||...|..|:
Human  1627 DLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEI 1691

  Fly   616 EEVRSHLDSANRAKRTVELQYEEAASRINELTTANVSLVSIKSKLEQELSVVASDYEEVSKELRI 680
            ||:|:.|:...|:::..|.:..:|:.|:..|.|.|.||::.|.|||.::|.:..:.|::.:|.|.
Human  1692 EELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARN 1756

  Fly   681 SDERYQKVQVELKHVVEQVHEEQERIVKLETIKKSLEVEVKNLSIRLEEVELNAVAGSKRIISKL 745
            ::|:.:|...:...:.|::.:||:....||.:||::|..||:|.:||:|.|..|:.|.|:.|.||
Human  1757 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKL 1821

  Fly   746 EARIRDLELELEEEKRRHAETIKILRKKERTVKEVLVQCEEDQKNLILLQDALDKSTAKINIYRR 810
            |||:|:||.|:|.|::|:||.:|.|||.||.|||:..|.|||:||::.|||.:||..||:..|:|
Human  1822 EARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKR 1886

  Fly   811 QLSEQEGVSQQTTTRVRRFQRELEAAEDRADTAESSLNIIRAKHR 855
            |..|.|..|.....:.|:.|.|||.||:|||.|||.:|.:|.|.|
Human  1887 QAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSR 1931

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prm	NP_523982.2	Myosin_tail_1	<34..853	CDD:460256	291/818 (36%)
MYH2	NP_060004.3	Myosin_N	33..77	CDD:460670
		MYSc_Myh2_mammals	100..772	CDD:276877
		Actin-binding. /evidence=ECO:0000250	661..683
		Actin-binding. /evidence=ECO:0000250	763..777
		Myosin_tail_1	852..1929	CDD:460256	293/821 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1128..1149		8/20 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1155..1174		10/18 (56%)