Protein Alignment Prm and MYO1B

DIOPT Version :10

• Sequence 1: NP_523982.2
• Gene: Prm / 39002
• FlyBaseID: FBgn0003149
• Length: 879
• Species: Drosophila melanogaster
• Sequence 2: XP_047300366.1
• Gene: MYO1B / 4430
• HGNCID: 7596
• Length: 1156
• Species: Homo sapiens
• Alignment Length: 685
• Identity: 130/685 - (18%)
• Similarity: 244/685 - (35%)
• Gaps: 215/685 - (31%)

  Fly   241 LEDARRRLEDEDRRRSLLESSLHQVEIELDSVRNQLEEESEARIDLERQLVKANADATSWQNKWN 305
            ::....||....||.|.|| ::.::|::...:.|.:.......::                 ..|
Human     1 MQSKEERLTSWGRRGSELE-TMAKMEVKTSLLDNMIGVGDMVLLE-----------------PLN 47

  Fly   306 SEVAARAEEVEEIRRKYQVRITELEEHIESLIVKVNNLEKMKTRLASEVEVLIIDLEKSNNSCRE 370
            .|..     :..:::::.  .:|:..:|.|:::.||....:......:||      |..|.:..|
Human    48 EETF-----INNLKKRFD--HSEIYTYIGSVVISVNPYRSLPIYSPEKVE------EYRNRNFYE 99

  Fly   371 LTKSVNTL-EKHNVELKSRLDETIILYETSQRDLKNKHADLVRTV--------HELDKVKDNNNQ 426
            |:..:..| ::....|:.:..:..||........|.:.:.||.:.        .|:::||:   |
Human   100 LSPHIFALSDEAYRSLRDQDKDQCILITGESGAGKTEASKLVMSYVAAVCGKGAEVNQVKE---Q 161

  Fly   427 LTRENKKLGDDLHEAKGAINELNRRLHE-LELELRRLENERDELTAAYKE--AEAGRKAEEQRGQ 488
            |.:.|..| :....||...|:.:.|..: :::|   .:.:.|.|......  .|..|..::.||:
Human   162 LLQSNPVL-EAFGNAKTVRNDNSSRFGKYMDIE---FDFKGDPLGGVISNYLLEKSRVVKQPRGE 222

  Fly   489 R---------------------LAADFNQYR--------------------------------HD 500
            |                     |..||::|.                                |:
Human   223 RNFHVFYQLLSGASEELLNKLKLERDFSRYNYLSLDSAKVNGVDDAANFRTVRNAMQIVGFMDHE 287

  Fly   501 AERRLAEKDEEIEAIRKQTSIEIEQLNARVIEAETRLK-TEVTRIKKKLQIQITELEMSLDVANK 564
            ||..||    .:.|:.|..:||        .:.|:|:. .:.::||.|.:::        ::...
Human   288 AESVLA----VVAAVLKLGNIE--------FKPESRVNGLDESKIKDKNELK--------EICEL 332

  Fly   565 TNIDLQKVIKKQSLQLTELQAHYEDVQRQLQATLDQYAVAQRRLAGLNGELEEVRSHLDSANRAK 629
            |.|| |.|::: :.....::|..|.|...|......||                |..|     ||
Human   333 TGID-QSVLER-AFSFRTVEAKQEKVSTTLNVAQAYYA----------------RDAL-----AK 374

  Fly   630 RTVELQYEEAASRINELTTANVSLVSIKSKLEQELSVVASD-YEEVSKE---LRISDERYQKVQV 690
            ......:....:||||...|.   ..::.|:...|.:...: :|:.|.|   :...:|:.|::.:
Human   375 NLYSRLFSWLVNRINESIKAQ---TKVRKKVMGVLDIYGFEIFEDNSFEQFIINYCNEKLQQIFI 436

  Fly   691 ELKHVVEQVHEEQERIVKLETIKKSLE---VEVKNLSIRLEEVELN---------------AVAG 737
            ||     .:.||||     |.|::.:|   ::..|.:|..:.:|.|               ....
Human   437 EL-----TLKEEQE-----EYIREDIEWTHIDYFNNAIICDLIENNTNGILAMLDEECLRPGTVT 491

  Fly   738 SKRIISKL----------EARIRDLELELEEEKRRHAETIKILRKKERTVKEVLVQCE--EDQKN 790
            .:..:.||          |:|:......|.:....|: ..:|    :....:||.|.|  .|:.|
Human   492 DETFLEKLNQVCATHQHFESRMSKCSRFLNDTSLPHS-CFRI----QHYAGKVLYQVEGFVDKNN 551

  Fly   791 LILLQD----------ALDKS------TAKINIYR 809
            .:|.:|          ||.||      .||||:.|
Human   552 DLLYRDLSQAMWKASHALIKSLFPEGNPAKINLKR 586

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prm	NP_523982.2	Myosin_tail_1	<34..853	CDD:460256	130/685 (19%)
MYO1B	XP_047300366.1	MYSc_Myo1	49..708	CDD:276829	120/619 (19%)
		IQ	769..791	CDD:197470
		Myosin_TH1	961..1138	CDD:461801