DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prm and MYO18A

DIOPT Version :9

Sequence 1:	NP_523982.2	Gene:	Prm / 39002	FlyBaseID:	FBgn0003149	Length:	879	Species:	Drosophila melanogaster
Sequence 2:	NP_001333694.1	Gene:	MYO18A / 399687	HGNCID:	31104	Length:	2058	Species:	Homo sapiens

Alignment Length:	851	Identity:	185/851 - (21%)
Similarity:	380/851 - (44%)	Gaps:	147/851 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 SLSRLEDKIRLLQDDLEVEREL------------RQRIEREK-ADLSVQVIQMSERLEEAEGGAE 87
            :|:|||:     |.|.:..|.|            ||..::.| .||:::.:|  :.:::.:|
Human  1195 TLARLEE-----QRDEQTSRNLTLFQAACRGYLARQHFKKRKIQDLAIRCVQ--KNIKKNKG--- 1249

  Fly    88 HQFEANRKRDAELLKL----RKLLEDVHLESEETTLLLKKKHNEIITDFQEQVEILTKNKARAEK 148
                   .:|....||    |.|:| |.|..|:                       .:||
Human  1250 -------VKDWPWWKLFTTVRPLIE-VQLSEEQ-----------------------IRNK----- 1278

  Fly   149 DKAKFQTEVYELLSQIESYNKEKIVSEKHISKLEVSISELNVKIEELNRTVIDISSHRSRLSQEN 213
                 ..|:.:|.|::|...||:.....:..:||..||||..::.:...|....|......:.|.
Human  1279 -----DEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAER 1338

  Fly   214 IELTKDVQDLKVQLDTVSFSKSQVISQLEDARRRL----------EDED---RRRSLLESSLHQV 265
            :...|::::|:.|.|  :..|...:.::|....||          :|:|   ..|...|.::.
Human  1339 LRAEKEMKELQTQYD--ALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVR-- 1399

  Fly   266 EIELDSVRNQLEEESEARIDLE----RQLVKANADATSWQNKWNSEVAARAEEVEEIRRKYQVRI 326
              |:|..:.:|::|.|.::::|    |||.:...|..:     :||.:.||  ::::::|.|...
Human  1400 --EVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQA-----DSEESQRA--LQQLKKKCQRLT 1455

  Fly   327 TELEE---HIESLIVKVNNLEKMKTRLASEVEVLIIDLEKSNNSCRELTKSVNTLEKHNVELKSR 388
            .||::   |:|...|:.:.|||.:.|..||:.....:.::......:|.:..:.|......||.:
Human  1456 AELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQ 1520

  Fly   389 LDETIILYETSQRDLKNKHADLVRTVHELD-KVKDNNNQLTRENKKLGDDLHEAKGAINELNRRL 452
            |:|       ...|:    |...:.|..|: :::|.::|.:::...|.           ::.::|
Human  1521 LEE-------KDMDI----AGFTQKVVSLEAELQDISSQESKDEASLA-----------KVKKQL 1563

  Fly   453 HELELELRRLENERDELTAAYKEAEAGR-KAEEQRGQRLAADFNQYRHDAERRLAEKDEEIEAIR 516
            .:||.:::..|.|.||        :||. :..||...||..:..:.|....:.:..:|||:|..|
Human  1564 RDLEAKVKDQEEELDE--------QAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEAR 1620

  Fly   517 KQTSIEIEQLNARVIEAETRLKTEVTRIKKKLQIQITELEMSLDVANKTNIDLQKVIKKQSLQLT 581
            :....:::|:..: :|.|...|.:|.|.|::|:.::..|.   |..|:.:.:.:|.::|   .|.
Human  1621 QSCQKKLKQMEVQ-LEEEYEDKQKVLREKRELEGKLATLS---DQVNRRDFESEKRLRK---DLK 1678

  Fly   582 ELQAHYEDVQRQLQATLDQYAVAQRRLAGLNGELEEVRSHLDSANRAKRTVELQYEEAASRINEL 646
            ..:|...|.|..|. .|...|.::|.:|.|..:|||......:|.:|::.:|::.|:...:|:::
Human  1679 RTKALLADAQLMLD-HLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDI 1742

  Fly   647 TTANVSLVSIKSKLEQELSVVASDYEEVSKELRISDERYQKVQVELKHVVEQVHEEQERIVKLET 711
            ..|..:|....|:|::|.:.:.:..||..:::....::::....:....:.|:::.|.::.:...
Human  1743 AKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANK 1807

  Fly   712 IKKSLEVEVKNLSIRLEEVELNAVAGSKRIISKLEARIRDLELELEEEKRRHAETIKILRKKERT 776
            .|:.|:.:::.|..::|.:|.:.|  .|.::|:.||:||:||..||.|:.:    :|.|......
Human  1808 EKQELQEKLQALQSQVEFLEQSMV--DKSLVSRQEAKIRELETRLEFERTQ----VKRLESLASR 1866

  Fly   777 VKEVLVQCEEDQKNLILLQDALDKSTAKINIYRRQLSEQEGVSQQTTTRVRRFQRELEAAEDRAD 841
            :||.:.:..|::...|..::...:...::....|...|:.|...:......|.:.|||...:..:
Human  1867 LKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLE 1931

  Fly   842 TAESSL 847
            .|..||
Human  1932 AANQSL 1937

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prm	NP_523982.2	Myosin_tail_1	<34..853	CDD:279860	185/851 (22%)
MYO18A	NP_001333694.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34
		Interaction with actin	114..118
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	140..167
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1469..1499		7/29 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1871..1920		6/48 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810