DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prm and Myo18a

DIOPT Version :9

Sequence 1:	NP_523982.2	Gene:	Prm / 39002	FlyBaseID:	FBgn0003149	Length:	879	Species:	Drosophila melanogaster
Sequence 2:	XP_036012684.1	Gene:	Myo18a / 360013	MGIID:	2667185	Length:	2493	Species:	Mus musculus

Alignment Length:	871	Identity:	187/871 - (21%)
Similarity:	392/871 - (45%)	Gaps:	153/871 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 LSRLEDKIRLLQDDLEVERELRQRIEREKADLSVQVIQM------SERLEEA--EGGAEH--QFE 91
            |::...:..::.|:.....||.:.::.||:...:.:.::      ..||||.  |..:.|  .|:
Mouse  1183 LTKKHGRNYIVVDEKRAVEELLESLDLEKSSCCLGLSRVFFRAGTLARLEEQRDEQTSRHLTLFQ 1247

  Fly    92 AN----------RKRDAELLKLRKLLEDVHLESEETTLLLKKKHN--------EIITDFQEQVEI 138
            |.          :||..:.|.:|.:.:::            ||:.        ::.|..:..:::
Mouse  1248 AACRGYLARQHFKKRKIQDLAIRCVQKNI------------KKNKGVKDWPWWKLFTTVRPLIQV 1300

  Fly   139 LTKNKARAEKDKAKFQTEVYELLSQIESYNKEKIVSEKHIS--KLEVSISELNVKIEELNRTVID 201
            ....:....||:     |:.:|.|::|...||:  :|..:|  :||..||||..::.:...|...
Mouse  1301 QLSEEQIRNKDE-----EIQQLRSKLEKVEKER--NELRLSSDRLETRISELTSELTDERNTGES 1358

  Fly   202 ISSHRSRLSQENIELTKDVQDLKVQLDTVSFSKSQVISQLEDARRRL----------EDED---R 253
            .|......:.|.:...|::::|:.|.|  :..|...:.::|....||          :|:|   .
Mouse  1359 ASQLLDAETAERLRTEKEMKELQTQYD--ALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGE 1421

  Fly   254 RRSLLESSLHQVEIELDSVRNQLEE----ESEARIDLERQLVKANADATSWQNKWNSEVAARAEE 314
            .|...|.::.:|:.....::.:||:    |.::|..|||:|....||         |:.:.||
Mouse  1422 WRLKYERAVREVDFTKKRLQQELEDKMEVEQQSRRQLERRLGDLQAD---------SDESQRA-- 1475

  Fly   315 VEEIRRKYQVRITELEE---HIESLIVKVNNLEKMKTRLASEVEVLIIDLEKSNNSCRELTKSVN 376
            ::::::|.|....||::   |:|...|:.:.|||.:.|..||:.....:.::......:|.:..:
Mouse  1476 LQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEETQREKLQREKLQREKD 1540

  Fly   377 TLEKHNVELKSRLDETIILYETSQRDLKNKHADLVRTVHELD-KVKDNNNQLTRENKKLGDDLHE 440
            .|......||.:::|         :||  ..|...:.|..|: :::|.::|.:::...|.
Mouse  1541 MLLAEAFSLKQQMEE---------KDL--DIAGFTQKVVSLEAELQDISSQESKDEASLA----- 1589

  Fly   441 AKGAINELNRRLHELELELRRLENERDELTAAYKEAEAGR-KAEEQRGQRLAADFNQYRHDAERR 504
                  ::.::|.:||.:::..|.|.||        :||. :..||...||..:..:.|....:.
Mouse  1590 ------KVKKQLRDLEAKVKDQEEELDE--------QAGSIQMLEQAKLRLEMEMERMRQTHSKE 1640

  Fly   505 LAEKDEEIEAIRKQTSIEIEQLNARVIEAETRLKTEVTRIKKKLQIQITELEMSLDVANKTNIDL 569
            :..:|||:|..|:....:::|:..: :|.|...|.:..|.|::|:.:::.|.   |..|:.:.:.
Mouse  1641 MESRDEEVEEARQSCQKKLKQMEVQ-LEEEYEDKQKALREKRELESKLSTLS---DQVNQRDFES 1701

  Fly   570 QKVIKKQSLQLTELQAHYEDVQRQLQATLDQYAVAQRRLAGLNGELEEVRSHLDSANRAKRTVEL 634
            :|.::|   .|...:|...|.|..|. .|...|.::|.:|.|..:|||......:|.:|::.:|:
Mouse  1702 EKRLRK---DLKRTKALLADAQIMLD-HLKNNAPSKREIAQLKNQLEESEFTCAAAVKARKAMEV 1762

  Fly   635 QYEEAASRINELTTANVSLVSIKSKLEQELSVVASDYEEVSKELRISDERYQKVQVELKHVVEQV 699
            :.|:...:|:::..|..:|....|:|::|.:.:.:..||..:::....::::....:....:.|:
Mouse  1763 EMEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDMAQM 1827

  Fly   700 HEEQERIVKLETIKKSLEVEVKNLSIRLEEVELNAVAGSKRIISKLEARIRDLELELEEEKRRHA 764
            ::.|.:|.:....|:.|:.:::.|..::|.:|.:.|  .|.::|:.||:||:||..||.||.:
Mouse  1828 NDLQAQIEESNKEKQELQEKLQALQSQVEFLEQSMV--DKSLVSRQEAKIRELETRLEFEKTQ-- 1888

  Fly   765 ETIKILRKKERTVKEVLVQCEEDQKNLILLQDALDKSTAKINIYRRQLSEQEGVSQQTTTRVRRF 829
              :|.|......:||.:.:..|::          |:..|..|..:.|              .:|.
Mouse  1889 --VKRLENLASRLKETMEKLTEER----------DQRAAAENREKEQ--------------NKRL 1927

  Fly   830 QREL-EAAEDRADTAESSLNIIRAKH 854
            ||:| :..|:.::.|.......|.||
Mouse  1928 QRQLRDTKEEMSELARKEAEASRKKH 1953

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prm	NP_523982.2	Myosin_tail_1	<34..853	CDD:279860	185/868 (21%)
Myo18a	XP_036012684.1	PDZ_signaling	220..308	CDD:238492
		COG5022	429..1950	CDD:227355	184/866 (21%)
		MYSc_Myo18	467..1224	CDD:276837	6/40 (15%)
		MDN1	<1782..2121	CDD:227596	44/202 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900