DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prm and Myo10A

DIOPT Version :9

Sequence 1:	NP_523982.2	Gene:	Prm / 39002	FlyBaseID:	FBgn0003149	Length:	879	Species:	Drosophila melanogaster
Sequence 2:	NP_001036269.2	Gene:	Myo10A / 32028	FlyBaseID:	FBgn0263705	Length:	3145	Species:	Drosophila melanogaster

Alignment Length:	937	Identity:	142/937 - (15%)
Similarity:	302/937 - (32%)	Gaps:	270/937 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 EDVHLESEETTLLLKKKHNEIITDFQEQVEILTKNKARAEK-------DKAKFQTEVYELLSQIE 165
            ::...::||.....|.:.::..|..|.|...:|.|....|.       .....:.|.:|    ||
  Fly  1743 DEPQFQTEEDFFAFKMRQHQRKTTPQAQHHQMTSNGGMMESGPGARGASATAIEWEEFE----IE 1803

  Fly   166 SYNKEKIVSEKHISKLEVSISELNVKIEELNRTVIDISSHRSR------------------LSQE 212
            |.....:..:         :...::::|....|.....::|.|                  |:::
  Fly  1804 SPTPPPMSGQ---------LMRSSIRLETTTTTTTSAVNNRDRDRETQDVGQPMQSVVTTKLAKK 1859

  Fly   213 NIELTKD------VQDLKVQLD--------TVSFSKSQVISQLEDARRRLEDEDRRRSLLESSLH 263
            :.|:..|      |..||:..:        |...|....:|...:.|...:.||.|:.:|:..|.
  Fly  1860 SFEIGADRPPPGSVGKLKLSSEMRQRLEQVTAGHSVRSTVSTKSEQRAPAKLEDTRKLMLQQQLG 1924

  Fly   264 QVEIELDSVRN----QLEEESEARIDLERQLVKANADATSWQNKW-------------------- 304
            .:...:....:    .::..:..|..:||...|.:.........|
  Fly  1925 GLFASVSGGNSGPGGVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRP 1989

  Fly   305 ------------NSEVAARAEEVEEIRRKYQVRITELEEHIESLIVKVNNLEKMKTRLASEVEVL 357
                        .|...||:.|.|...|....::  ::||:.:.|
  Fly  1990 PSMAPPAPPPAPQSPPTARSPEPEPDYRTSSSQV--VKEHVPAFI-------------------- 2032

  Fly   358 IIDLEKSNNSCRELTKSVNTLEKHNVELKSRLDETIILYETSQRDLKNKHADLVRTVHELDKVKD 422
                ::.........:....:..|::.|:               |.....:..|....:.::.:.
  Fly  2033 ----QRQERDTFGAVRQQQMISSHHLHLE---------------DHSASSSPAVAAWEQAERERS 2078

  Fly   423 NNNQLTRENKKLGDDLHE-------AKGAINELNRRLHELE----LELRRLENERD--------- 467
            .:...:|:.:...:.:.:       |.|:.:|..|...|.|    .|:|::|.||:
  Fly  2079 RSRSRSRDREDYSESVWDRAEVEGPASGSGSEKEREKRERERERLYEIRQVERERESHKVYQPAP 2143

  Fly   468 -ELTAAYKEAEAGRKAEEQRGQRLAADF-----NQYRHDAERRLAEKD---EEIEAIRKQTSIEI 523
             .:..|..:...|.:.|::.|.  .|.|     .:|.|:.:|:.:...   ||::::...|...:
  Fly  2144 PRVIQASMDTTGGHRREDRTGG--LATFRTHMAQKYEHERKRKSSASSGMREELDSMHMTTPPPV 2206

  Fly   524 EQLNARVIEAETRLKTEVT-------------------------RIKKKLQIQITELEMSLDVAN 563
                  ::.|.....:..:                         |:..||:::....:....:..
  Fly  2207 ------IVPAPVPPPSSTSPGLGVVSGVLMGSGSGGSTACLTYNRVPWKLRVRKEVFQPHEPIGP 2265

  Fly   564 KTNIDL--QKVI--------------KKQSLQLTELQAHYEDVQRQLQATLDQYAVAQRRLAGLN 612
            ...:||  .:|:              :::|..|..|..|...|.     ||.....:.....|..
  Fly  2266 PVALDLLFAQVLGDVFGVTPCLRITPQEKSSALNMLHGHGVSVD-----TLSNRNGSGAGGGGNG 2325

  Fly   613 GELEE-VRSHLDSANR-----AKRTVELQYEEAASRINELTTANVSLVSIKSKLEQELSVVASDY 671
            |::.. |:.||....|     ..|...:|.......::.:..::..|...:...:..:.|.|..:
  Fly  2326 GQVRALVKRHLVDMARDWPLYFARLFAVQGAPLYPDVSIMGVSHSGLYLARRDADYLIVVQAISF 2390

  Fly   672 EEV------------------SKELRISDERYQKVQVELKHVVEQVHEEQERIVKLETIKKSLEV 718
            .|:                  .|.|.:...|...:|..:...|::..:.|.   |..|:......
  Fly  2391 GEIQSAVTLPRPAALQLNLRNGKHLALHAARAAAIQSMVTTFVQEFRKSQS---KASTLSSGARA 2452

  Fly   719 EVKNLSIRLEEVELNAVAGSKRIISKLEARIRDLELELEEEKRRHAETIKILRKKERTVKEVLVQ 783
            ..:.|::.||.:| :..|.::|....::...|..|...:.|...|      |:::::..::  .|
  Fly  2453 AAQTLNVPLERLE-SRQAHAQRNEHGVDGGSRQNEQLQQSELHHH------LQQQQQQQQQ--QQ 2508

  Fly   784 CEEDQKNLILLQDALDK---STAKINIYRRQLSEQEGVSQQTTTRVRRFQRELEAAEDRADTAES 845
            ..:.|:....|:||:::   :|......::||.:|:|..|       ||.::           :|
  Fly  2509 HHQQQQQQQQLEDAMEEQHMATDHQQQQQQQLGQQQGQQQ-------RFLKQ-----------QS 2555

  Fly   846 SLNIIRAKHRTFVTTSTVPGSQVYIQE 872
            .|:..| |.......|::...||:.||
  Fly  2556 YLHSAR-KSNAGQQPSSLTNGQVHHQE 2581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prm	NP_523982.2	Myosin_tail_1	<34..853	CDD:279860	136/916 (15%)
Myo10A	NP_001036269.2	MYSc	156..836	CDD:214580
		MYSc_Myo15	169..828	CDD:276838
		MyTH4	1014..1171	CDD:295320
		MyTH4	2704..2810	CDD:279165
		B41	2823..3033	CDD:214604
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466286
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840