DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prm and Myh7b

DIOPT Version :9

Sequence 1:	NP_523982.2	Gene:	Prm / 39002	FlyBaseID:	FBgn0003149	Length:	879	Species:	Drosophila melanogaster
Sequence 2:	NP_001101264.2	Gene:	Myh7b / 311570	RGDID:	1307994	Length:	1941	Species:	Rattus norvegicus

Alignment Length:	841	Identity:	297/841 - (35%)
Similarity:	492/841 - (58%)	Gaps:	19/841 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 DLSSLS-RLED----------KIRLLQ-------DDLEVERELRQRIEREKADLSVQVIQMSERL 79
            :||.|| |:||          ||:.||       ::||.||..|.|:|:::|:.:.::.::||||
  Rat  1093 ELSQLSLRVEDEQLLGAQLQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERL 1157

  Fly    80 EEAEGGAEHQFEANRKRDAELLKLRKLLEDVHLESEETTLLLKKKHNEIITDFQEQVEILTKNKA 144
            |||.|.:..|.|..|||:|||.:||:.||:..|..|.|...|::|..:...:..|||:.|.:.:.
  Rat  1158 EEAGGASAGQREGCRKREAELGRLRRELEETVLRHEATVAALRRKQADSAAELSEQVDSLQRIRQ 1222

  Fly   145 RAEKDKAKFQTEVYELLSQIESYNKEKIVSEKHISKLEVSISELNVKIEELNRTVIDISSHRSRL 209
            :.||:|::.:.||.:|.:.:|:..:.|..:||.....|..:||..:|:|||.|.:.|.|:.|.||
  Rat  1223 KLEKEKSELRMEVDDLGASVETLARGKASAEKLCRTYEDQLSEAKIKVEELQRQLTDASTQRGRL 1287

  Fly   210 SQENIELTKDVQDLKVQLDTVSFSKSQVISQLEDARRRLEDEDRRRSLLESSLHQVEIELDSVRN 274
            ..||.||.:.:::.:..:..:|..|:.....||:.||:||:|.:.:..|..::..:..:.|.:|.
  Rat  1288 QTENGELGRLLEEKESMISQLSRGKTSAAQSLEELRRQLEEESKAKGALAHAVQALRHDCDLLRE 1352

  Fly   275 QLEEESEARIDLERQLVKANADATSWQNKWNSEVAARAEEVEEIRRKYQVRITELEEHIESLIVK 339
            |.||||||:.:|:|.|.||||:...|::|:.::...|.||:||.::|..:|:.|.||.:|:...|
  Rat  1353 QHEEESEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAK 1417

  Fly   340 VNNLEKMKTRLASEVEVLIIDLEKSNNSCRELTKSVNTLEKHNVELKSRLDETIILYETSQRDLK 404
            .::|||.|.||.:|.|.:.::||::.::...|.|....||:...|.:.:.:|.....|.:||:.:
  Rat  1418 CSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQREAR 1482

  Fly   405 NKHADLVRTVHELDKVKDNNNQLTRENKKLGDDLHEAKGAINELNRRLHELELELRRLENERDEL 469
            ....:|.|..|..::..:....|.||||.|.:::.:....::...:.:.|||...:.||.|:.||
  Rat  1483 GLGTELFRLRHSHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKAKKALEGEKSEL 1547

  Fly   470 TAAYKEAEAGRKAEEQRGQRLAADFNQYRHDAERRLAEKDEEIEAIRKQTSIEIEQLNARVIEAE 534
            .||.:|||...:.||.:..|:..:.:|.:.:.:|:|||||||...:|:.....:|.|.|. ::||
  Rat  1548 QAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECTNLRRNHQRAVESLQAS-LDAE 1611

  Fly   535 TRLKTEVTRIKKKLQIQITELEMSLDVANKTNIDLQKVIKKQSLQLTELQAHYEDVQRQLQATLD 599
            ||.:.|..|:|||::..:.:||:.|..|.:..::.|...:....||.|.||..::.||......:
  Rat  1612 TRARNEALRLKKKMEGDLNDLELQLGHATRQAMEAQAATRLLQAQLKEEQAGRDEEQRLAAELRE 1676

  Fly   600 QYAVAQRRLAGLNGELEEVRSHLDSANRAKRTVELQYEEAASRINELTTANVSLVSIKSKLEQEL 664
            |....:||.|.|..||||:|:.|:...|::|..|.:..||..|:|.|.:.|..|::.|.|||.:|
  Rat  1677 QGQALERRAALLASELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEVDL 1741

  Fly   665 SVVASDYEEVSKELRISDERYQKVQVELKHVVEQVHEEQERIVKLETIKKSLEVEVKNLSIRLEE 729
            :.::.:.||.::|.|.::|:.:|...:...:.|::.:||:....||.:||:||..|:.|..||||
  Rat  1742 AQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEE 1806

  Fly   730 VELNAVAGSKRIISKLEARIRDLELELEEEKRRHAETIKILRKKERTVKEVLVQCEEDQKNLILL 794
            .|..|:.|.|:.:.||||::|:||.||:.|:::|||.:|.:||.||.|||:..|.|||:|||..:
  Rat  1807 AEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQTEEDRKNLARM 1871

  Fly   795 QDALDKSTAKINIYRRQLSEQEGVSQQTTTRVRRFQRELEAAEDRADTAESSLNIIRAKHR 855
            ||.:||..:|:..|:||..|.|..:.....:.|:.|.||:.||:|||.||:..|.:||:.|
  Rat  1872 QDLVDKLQSKVKSYKRQFEEAEQQASTNLAKYRKAQHELDDAEERADMAETQANKLRARSR 1932

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prm	NP_523982.2	Myosin_tail_1	<34..853	CDD:279860	295/836 (35%)
Myh7b	NP_001101264.2	Myosin_N	32..71	CDD:397036
		myosin head (motor domain)	86..773
		MYSc_Myh7b	98..773	CDD:276953
		Myosin_tail_1	853..1930	CDD:396244	295/837 (35%)
		myosin tail	1075..1933		297/841 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810