DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prm and Myh6

DIOPT Version :9

Sequence 1:	NP_523982.2	Gene:	Prm / 39002	FlyBaseID:	FBgn0003149	Length:	879	Species:	Drosophila melanogaster
Sequence 2:	NP_058935.2	Gene:	Myh6 / 29556	RGDID:	62029	Length:	1939	Species:	Rattus norvegicus

Alignment Length:	825	Identity:	287/825 - (34%)
Similarity:	495/825 - (60%)	Gaps:	1/825 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 IQDLSSLSRLEDKIRLLQDDLEVERELRQRIEREKADLSVQVIQMSERLEEAEGGAEHQFEANRK 95
            :|....|...:.:|..|:::||.||..|.::|:.::||:.::.::|||||||.|....|.|.|:|
  Rat  1104 LQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLTRELEEISERLEEAGGATSVQIEMNKK 1168

  Fly    96 RDAELLKLRKLLEDVHLESEETTLLLKKKHNEIITDFQEQVEILTKNKARAEKDKAKFQTEVYEL 160
            |:||..|:|:.||:..|:.|.|...|:|||.:.:.:..||::.|.:.|.:.||:|::|:.|:.::
  Rat  1169 REAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDV 1233

  Fly   161 LSQIESYNKEKIVSEKHISKLEVSISELNVKIEELNRTVIDISSHRSRLSQENIELTKDVQDLKV 225
            .|.:|...|.|...||....||...:|..||:||..|::.|.::.|::|..||.||.:.:::.:.
  Rat  1234 TSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEA 1298

  Fly   226 QLDTVSFSKSQVISQLEDARRRLEDEDRRRSLLESSLHQVEIELDSVRNQLEEESEARIDLERQL 290
            .:..::..|.....|:||.:|:||:|.:.::.|..:|.....:.|.:|.|.|||.||:.:|:|.|
  Rat  1299 LISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEEMEAKAELQRVL 1363

  Fly   291 VKANADATSWQNKWNSEVAARAEEVEEIRRKYQVRITELEEHIESLIVKVNNLEKMKTRLASEVE 355
            .|||::...|:.|:.::...|.||:||.::|...|:.:.||.:|::..|.::|||.|.||.:|:|
  Rat  1364 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIE 1428

  Fly   356 VLIIDLEKSNNSCRELTKSVNTLEKHNVELKSRLDETIILYETSQRDLKNKHADLVRTVHELDKV 420
            .|::|:|:||.:...|.|.....:|...|.|.:.:|:....|:||::.::...:|.:..:..::.
  Rat  1429 DLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEES 1493

  Fly   421 KDNNNQLTRENKKLGDDLHEAKGAINELNRRLHELELELRRLENERDELTAAYKEAEAGRKAEEQ 485
            .::.....||||.|.:::.:....:.|..:.:||||...::||.|:.||.:|.:||||..:.||.
  Rat  1494 LEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKIRKQLEVEKLELQSALEEAEASLEHEEG 1558

  Fly   486 RGQRLAADFNQYRHDAERRLAEKDEEIEAIRKQTSIEIEQLNARVIEAETRLKTEVTRIKKKLQI 550
            :..|...:|||.:.:.||:|||||||:|..::.....::.|... ::||||.:.|..|:|||::.
  Rat  1559 KILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTS-LDAETRSRNEALRVKKKMEG 1622

  Fly   551 QITELEMSLDVANKTNIDLQKVIKKQSLQLTELQAHYEDVQRQLQATLDQYAVAQRRLAGLNGEL 615
            .:.|:|:.|..||:...:.||.:|.....|.:.|...:|..|......:..|:.:||...|..||
  Rat  1623 DLNEMEIQLSQANRIASEAQKHLKNAQAHLKDTQLQLDDAVRANDDLKENIAIVERRNTLLQAEL 1687

  Fly   616 EEVRSHLDSANRAKRTVELQYEEAASRINELTTANVSLVSIKSKLEQELSVVASDYEEVSKELRI 680
            ||:|:.::...|:::..|.:..|.:.|:..|.:.|.||::.|.|::.:||.:.::.||..:|.|.
  Rat  1688 EELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRN 1752

  Fly   681 SDERYQKVQVELKHVVEQVHEEQERIVKLETIKKSLEVEVKNLSIRLEEVELNAVAGSKRIISKL 745
            ::|:.:|...:...:.|::.:||:....||.:||::|..:|:|..||:|.|..|:.|.|:.:.||
  Rat  1753 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKL 1817

  Fly   746 EARIRDLELELEEEKRRHAETIKILRKKERTVKEVLVQCEEDQKNLILLQDALDKSTAKINIYRR 810
            |||:|:||.|||.|::|:||::|.:||.||.:||:..|.|||:|||:.|||.:||...|:..|:|
  Rat  1818 EARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLVRLQDLVDKLQLKVKAYKR 1882

  Fly   811 QLSEQEGVSQQTTTRVRRFQRELEAAEDRADTAESSLNIIRAKHR 855
            |..|.|..:....::.|:.|.||:.||:|||.|||.:|.:|||.|
  Rat  1883 QAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSR 1927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prm	NP_523982.2	Myosin_tail_1	<34..853	CDD:279860	283/818 (35%)
Myh6	NP_058935.2	Myosin_N	34..72	CDD:397036
		MYSc_class_II	99..768	CDD:276951
		Actin-binding	657..679
		Actin-binding	759..773
		Calmodulin-binding. /evidence=ECO:0000250	790..807
		Calmodulin-binding. /evidence=ECO:0000250	816..833
		Myosin_tail_1	848..1925	CDD:396244	284/821 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1908..1939		13/20 (65%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810