DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prm and Myh1

DIOPT Version :9

Sequence 1:	NP_523982.2	Gene:	Prm / 39002	FlyBaseID:	FBgn0003149	Length:	879	Species:	Drosophila melanogaster
Sequence 2:	NP_001128630.1	Gene:	Myh1 / 287408	RGDID:	735061	Length:	1942	Species:	Rattus norvegicus

Alignment Length:	819	Identity:	293/819 - (35%)
Similarity:	491/819 - (59%)	Gaps:	1/819 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 LSRLEDKIRLLQDDLEVERELRQRIEREKADLSVQVIQMSERLEEAEGGAEHQFEANRKRDAELL 101
            :..|:.:|..|::::|.||..|.:.|::::|||.::.::|||||||.|....|.|.|:||:||..
  Rat  1115 IKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQ 1179

  Fly   102 KLRKLLEDVHLESEETTLLLKKKHNEIITDFQEQVEILTKNKARAEKDKAKFQTEVYELLSQIES 166
            |:|:.||:..|:.|.|...|:|||.:.:.:..||::.|.:.|.:.||:|::.:.|:.:|.|.:|.
  Rat  1180 KMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMEV 1244

  Fly   167 YNKEKIVSEKHISKLEVSISELNVKIEELNRTVIDISSHRSRLSQENIELTKDVQDLKVQLDTVS 231
            .:|.|...||....||..:|||..|.||..|.:.::::.|.||..|:.|.::.:.:....:..:|
  Rat  1245 ISKSKGNLEKMCRTLEDQVSELKTKEEEQQRLINELTAQRGRLQTESGEYSRQLDEKDSLVSQLS 1309

  Fly   232 FSKSQVISQLEDARRRLEDEDRRRSLLESSLHQVEIELDSVRNQLEEESEARIDLERQLVKANAD 296
            ..|.....|:|:.:|:||:|.:.:|.|..:|.....:.|.:|.|.|||.||:.:|:|.:.|||::
  Rat  1310 RGKQAFTQQIEELKRQLEEEVKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSE 1374

  Fly   297 ATSWQNKWNSEVAARAEEVEEIRRKYQVRITELEEHIESLIVKVNNLEKMKTRLASEVEVLIIDL 361
            ...|:.|:.::...|.||:||.::|...|:.:.|||:|::..|..:|||.|.||.:|||.|:||:
  Rat  1375 VAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDV 1439

  Fly   362 EKSNNSCRELTKSVNTLEKHNVELKSRLDETIILYETSQRDLKNKHADLVRTVHELDKVKDNNNQ 426
            |::|.:|..|.|.....:|...|.|.:.:||....|.||::.::...:|.:..:..::..|....
  Rat  1440 ERTNAACAALDKKQRNFDKILAEWKQKYEETHAELEASQKESRSLSTELFKIKNAYEESLDQLET 1504

  Fly   427 LTRENKKLGDDLHEAKGAINELNRRLHELELELRRLENERDELTAAYKEAEAGRKAEEQRGQRLA 491
            |.||||.|..::.:....|.|..:|:||||...:::|.|:.||.||.:||||..:.||.:..|:.
  Rat  1505 LKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQIEQEKSELQAALEEAEASLEHEEGKILRIQ 1569

  Fly   492 ADFNQYRHDAERRLAEKDEEIEAIRKQTSIEIEQLNARVIEAETRLKTEVTRIKKKLQIQITELE 556
            .:.||.:.:.:|::|||||||:.: |:..|.:.:.....::||.|.:.:..|||||::..:.|:|
  Rat  1570 LELNQVKSEIDRKIAEKDEEIDQL-KRNHIRVVESMQSTLDAEIRSRNDAIRIKKKMEGDLNEME 1633

  Fly   557 MSLDVANKTNIDLQKVIKKQSLQLTELQAHYEDVQRQLQATLDQYAVAQRRLAGLNGELEEVRSH 621
            :.|:.:|:...:..:..:.....|.:.|.|.:|..|..:...:|.|:.:||...|..|:||:|:.
  Rat  1634 IQLNHSNRMAAEALRNYRNTQGILKDTQLHLDDALRGQEDLKEQLAMVERRANLLQAEIEELRAT 1698

  Fly   622 LDSANRAKRTVELQYEEAASRINELTTANVSLVSIKSKLEQELSVVASDYEEVSKELRISDERYQ 686
            |:...|:::..|.:..:|:.|:..|.|.|.||::.|.|||.::|.:..:.|::.:|.|.::|:.:
  Rat  1699 LEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAK 1763

  Fly   687 KVQVELKHVVEQVHEEQERIVKLETIKKSLEVEVKNLSIRLEEVELNAVAGSKRIISKLEARIRD 751
            |...:...:.|::.:||:....||.:||:||..||:|..||:|.|..|:.|.|:.|.|||||:|:
  Rat  1764 KAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRE 1828

  Fly   752 LELELEEEKRRHAETIKILRKKERTVKEVLVQCEEDQKNLILLQDALDKSTAKINIYRRQLSEQE 816
            ||.|:|.|::|:.|.||.|||.||.|||:..|.|||:||::.|||.:||..:|:..|:||..|.|
  Rat  1829 LEGEVENEQKRNVEAIKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQSKVKAYKRQAEEAE 1893

  Fly   817 GVSQQTTTRVRRFQRELEAAEDRADTAESSLNIIRAKHR 855
            ..|.....:.|:.|.|||.||:|||.|||.:|.:|.|.|
  Rat  1894 EQSNVNLAKFRKIQHELEEAEERADIAESQVNKLRVKSR 1932

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prm	NP_523982.2	Myosin_tail_1	<34..853	CDD:279860	291/815 (36%)
Myh1	NP_001128630.1	Myosin_N	35..73	CDD:397036
		MYSc_Myh1_mammals	100..773	CDD:276875
		Myosin_tail_1	853..1930	CDD:396244	291/815 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900