DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prm and Myh3

DIOPT Version :9

Sequence 1:	NP_523982.2	Gene:	Prm / 39002	FlyBaseID:	FBgn0003149	Length:	879	Species:	Drosophila melanogaster
Sequence 2:	NP_036736.1	Gene:	Myh3 / 24583	RGDID:	3138	Length:	1940	Species:	Rattus norvegicus

Alignment Length:	851	Identity:	296/851 - (34%)
Similarity:	505/851 - (59%)	Gaps:	15/851 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 NIEY------IQDLSSLS-RLEDKIRLLQ-------DDLEVERELRQRIEREKADLSVQVIQMSE 77
            :.||      ::|..:|| :|:.||:.||       :::|.||..|.:.|::::|.:.::.::||
  Rat  1085 DFEYSQLQSKVEDEQTLSLQLQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSE 1149

  Fly    78 RLEEAEGGAEHQFEANRKRDAELLKLRKLLEDVHLESEETTLLLKKKHNEIITDFQEQVEILTKN 142
            |||||.|....|.|.|:||:||.||||:.||:..|:.|.|...|:|||.:...:..||::.|.:.
  Rat  1150 RLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEATVATLRKKHADSAAELAEQIDNLQRV 1214

  Fly   143 KARAEKDKAKFQTEVYELLSQIESYNKEKIVSEKHISKLEVSISELNVKIEELNRTVIDISSHRS 207
            |.:.||:|::|:.|:.:|.|.:||.:|.|...||....||..:||...|.||..|::.::::.:|
  Rat  1215 KQKLEKEKSEFKLEIDDLSSSVESVSKSKANLEKICRTLEDQLSEARGKNEETQRSLSELTTQKS 1279

  Fly   208 RLSQENIELTKDVQDLKVQLDTVSFSKSQVISQLEDARRRLEDEDRRRSLLESSLHQVEIELDSV 272
            ||..|..||::.:::.:..:..:|.||.....|:|:.:|:||:|::.::.|..:|.....:.|.:
  Rat  1280 RLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQIEELKRQLEEENKAKNALAHALQSSRHDCDLL 1344

  Fly   273 RNQLEEESEARIDLERQLVKANADATSWQNKWNSEVAARAEEVEEIRRKYQVRITELEEHIESLI 337
            |.|.|||.|.:.:|:|.|.|||::...|:.|:.::...|.||:||.::|...|:.:.||.:|::.
  Rat  1345 REQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVN 1409

  Fly   338 VKVNNLEKMKTRLASEVEVLIIDLEKSNNSCRELTKSVNTLEKHNVELKSRLDETIILYETSQRD 402
            .|..:|||.|.||..|||.|::|:|::|:....|.|.....:|...|.|::.:|:....|.:.::
  Rat  1410 AKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEAALKE 1474

  Fly   403 LKNKHADLVRTVHELDKVKDNNNQLTRENKKLGDDLHEAKGAINELNRRLHELELELRRLENERD 467
            .::...:|.:..:..::..|....:.||||.|..::.:....|.|..:.:||||...:::|.|:.
  Rat  1475 SRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKSIHELEKSRKQMELEKA 1539

  Fly   468 ELTAAYKEAEAGRKAEEQRGQRLAADFNQYRHDAERRLAEKDEEIEAIRKQTSIEIEQLNARVIE 532
            ::..|.:||||..:.||.:..|:..:..|.:.:.:|::||||||||.:::.....:|.:.. .::
  Rat  1540 DIQMALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQG-ALD 1603

  Fly   533 AETRLKTEVTRIKKKLQIQITELEMSLDVANKTNIDLQKVIKKQSLQLTELQAHYEDVQRQLQAT 597
            ||.|.:.|..|:|||::..:.|:|:.|..||:...:..|.::....||.:.|.|.:|..|..:..
  Rat  1604 AEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETIKHLRSVQGQLKDTQLHLDDALRGQEDL 1668

  Fly   598 LDQYAVAQRRLAGLNGELEEVRSHLDSANRAKRTVELQYEEAASRINELTTANVSLVSIKSKLEQ 662
            .:|.|:.:||...|..|:||:|:.|:...||::..|.:..::..|:..|.|.|.||:..|.|||.
  Rat  1669 KEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLET 1733

  Fly   663 ELSVVASDYEEVSKELRISDERYQKVQVELKHVVEQVHEEQERIVKLETIKKSLEVEVKNLSIRL 727
            :|:.:.|:.|:.|::.|.::|:.:|...:...:.|::.:||:....||.:||:||..||:|..||
  Rat  1734 DLTQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRL 1798

  Fly   728 EEVELNAVAGSKRIISKLEARIRDLELELEEEKRRHAETIKILRKKERTVKEVLVQCEEDQKNLI 792
            :|.|..|:.|.|:.|.|||.|||:||.|||.|::|:.|::|.|||.||.|||:..|.|||:||::
  Rat  1799 DEAEQLALKGGKKQIQKLETRIRELEFELEGEQKRNTESVKGLRKYERRVKELTYQSEEDRKNVL 1863

  Fly   793 LLQDALDKSTAKINIYRRQLSEQEGVSQQTTTRVRRFQRELEAAEDRADTAESSLNIIRAKHRTF 857
            .|||.:||...|:..|:||..|.:..:....|:.|:.|.|||.||:|||.|||.:|.:|||.|.|
  Rat  1864 RLQDLVDKLQVKVKSYKRQAEEADEQANVHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRDF 1928

  Fly   858 VTTSTV 863
            .::..|
  Rat  1929 TSSRMV 1934

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prm	NP_523982.2	Myosin_tail_1	<34..853	CDD:279860	288/826 (35%)
Myh3	NP_036736.1	Myosin_N	36..73	CDD:280832
		Myosin_head	88..767	CDD:278492
		MYSc_Myh3	100..767	CDD:276878
		Actin-binding	656..678
		Actin-binding	758..772
		GrpE	843..>962	CDD:295646
		Myosin_tail_1	847..1924	CDD:279860	291/839 (35%)
		RILP-like	962..1095	CDD:304877	2/9 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1260..1289		9/28 (32%)
		MIT_CorA-like	<1296..>1408	CDD:294313	36/111 (32%)
		COG6	1373..>1506	CDD:303003	38/132 (29%)
		TMPIT	1739..>1828	CDD:285135	35/88 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810