Protein Alignment Prm and MYH15

DIOPT Version :9

• Sequence 1: NP_523982.2
• Gene: Prm / 39002
• FlyBaseID: FBgn0003149
• Length: 879
• Species: Drosophila melanogaster
• Sequence 2: XP_011510861.1
• Gene: MYH15 / 22989
• HGNCID: 31073
• Length: 1946
• Species: Homo sapiens
• Alignment Length: 823
• Identity: 256/823 - (31%)
• Similarity: 469/823 - (56%)
• Gaps: 3/823 - (0%)

  Fly    36 SLSRLEDKIRLLQDDLEVERELRQRIEREKADLSVQVIQMSERLEEAEGGAEHQFEANRKRDAEL 100
            ::..|:.:|:.|::.||.||..|.::|||:|||:..:..::|||||..|.:..|.|..:|::.:.
Human  1119 TVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQETKF 1183

  Fly   101 LKLRKLLEDVHLESEETTLLLKKKHNEIITDFQEQVEILTKNKARAEKDKAKFQTEVYELLSQIE 165
            .||.:.:|:..|..|.|:..|||:|.:.:.:.:.|||.|.:.|.:.||||:..|.||.:||:::|
Human  1184 QKLHRDMEEATLHFETTSASLKKRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVE 1248

  Fly   166 SYNKEKIVSEKHISKLEVSISELNVKIEELNRTVIDISSHRSRLSQENIELTKDVQDLKVQLDTV 230
            ...:.|..:||..:..|..:.|...|::::.:...|:::.:::|..|:.|..:.:::.:..::.:
Human  1249 QMTRAKANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQL 1313

  Fly   231 SFSKSQVISQLEDARRRLEDEDRRRSLLESSLHQVEIELDSVRNQLEEESEARIDLERQLVKANA 295
            |..||....|:||.|.:||.|.:.:|.|..:|.:.:.:.|.:|.|.|||.|.:.:|.|.|.|.||
Human  1314 SREKSNFTRQIEDLRGQLEKETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNA 1378

  Fly   296 DATSWQNKWNSEVAARAEEVEEIRRKYQVRITELEEHIESLIVKVNNLEKMKTRLASEVEVLIID 360
            :...|:.|:.:.|..|.|::|:.:::..:|:.|..|.:.....:..:||:.:.:|..|:...:.|
Human  1379 EMVQWRMKYENNVIQRTEDLEDAKKELAIRLQEAAEAMGVANARNASLERARHQLQLELGDALSD 1443

  Fly   361 LEKSNNSCRELTKSVNTLEKHNVELKSRLDETIILYETSQRDLKNKHADLVRTVHELDKVKDNNN 425
            |.|..::...|.:......|...:.|.:.:|:..|.:.||::::....:|::..:..::......
Human  1444 LGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEESIVGQE 1508

  Fly   426 QLTRENKKLGDDLHEAKGAINELNRRLHELELELRRLENERDELTAAYKEAEAGRKAEEQRGQRL 490
            .|.||||.|.:::......:.|..:.|.|:|...:.:|.|:.|:....:|.|...:..|.:....
Human  1509 TLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKILHF 1573

  Fly   491 AADFNQYRHDAERRLAEKDEEIEAIRKQTSIEIEQLNARVIEAETRLKTEVTRIKKKLQIQITEL 555
            ..:..:.:.:.||:|:|||||||..|::....|:.|.:. :::|.:.:.||||:|||::..:.|:
Human  1574 QLELLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSS-LDSEAKSRIEVTRLKKKMEEDLNEM 1637

  Fly   556 EMSLDVANKTNIDLQKVIKKQSLQLTELQAHYEDVQRQLQATL-DQYAVAQRRLAGLNGELEEVR 619
            |:.|..||:...:..|.:.:..:|:.:||...:| ..||.:.| :|.|||:||.:.|..|||::|
Human  1638 ELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDD-STQLNSDLKEQVAVAERRNSLLQSELEDLR 1701

  Fly   620 SHLDSANRAKRTVELQYEEAASRINELTTANVSLVSIKSKLEQELSVVASDYEEVSKELRISDER 684
            |..:...|.:|..|.:..||..|||...|.|.||:|.|.|||.:::.:..:.|||.:|.:.::|:
Human  1702 SLQEQTERGRRLSEEELLEATERINLFYTQNTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEK 1766

  Fly   685 YQKVQVELKHVVEQVHEEQERIVKLETIKKSLEVEVKNLSIRLEEVELNAVAGSKRIISKLEARI 749
            .:|..:|..::.|::.::|:.|..||..::::|..:.:|..||.|.|..|:.||::.|.|||:|:
Human  1767 AKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLAEAEQMALMGSRKQIQKLESRV 1831

  Fly   750 RDLELELEEEKRRHAETIKILRKKERTVKEVLVQCEEDQKNLILLQDALDKSTAKINIYRRQLSE 814
            |:||.|||.|.||.||..:..|:.||.:||:..|.|||:|||..:|..:||...|:..|::|:..
Human  1832 RELEGELEGEIRRSAEAQRGARRLERCIKELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEV 1896

  Fly   815 QEGVSQQTTTRVRRFQRELEAAEDRADTAESSLNIIRAKHRTF 857
            .|..:.|..::.::.|.||...::||:.|||.:|.::.|.|.|
Human  1897 AETQANQYLSKYKKQQHELNEVKERAEVAESQVNKLKIKAREF 1939

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prm	NP_523982.2	Myosin_tail_1	<34..853	CDD:279860	253/817 (31%)
MYH15	XP_011510861.1	Myosin_N	52..90	CDD:280832
		Myosin_head	105..778	CDD:278492
		MYSc_Myh15_mammals	117..778	CDD:276892
		Myosin_tail_1	859..1935	CDD:279860	253/817 (31%)
		CENP-Q	1017..1164	CDD:289839	17/44 (39%)
		DUF2317	<1487..1600	CDD:302887	27/112 (24%)
		DUF4337	<1864..>1940	CDD:290935	27/76 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810