DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prm and myo-5

DIOPT Version :9

Sequence 1:	NP_523982.2	Gene:	Prm / 39002	FlyBaseID:	FBgn0003149	Length:	879	Species:	Drosophila melanogaster
Sequence 2:	NP_505094.1	Gene:	myo-5 / 179190	WormBaseID:	WBGene00019064	Length:	1974	Species:	Caenorhabditis elegans

Alignment Length:	869	Identity:	292/869 - (33%)
Similarity:	496/869 - (57%)	Gaps:	28/869 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 DVNIEYIQDLSSLSRLED-----------------KIRLLQDDLEVERELRQRIEREKADLSVQV 72
            |:.:..||     |||||                 :|:.|:::|:.||..|.:.|:.:.::.:::
Worm  1094 DIELSSIQ-----SRLEDEQSLVAKLQRQIKELLARIQELEEELDAERNSRSKAEKARNEMQMEL 1153

  Fly    73 IQMSERLEEAEGGAEHQFEANRKRDAELLKLRKLLEDVHLESEETTLLLKKKHNEIITDFQEQVE 137
            .::.:||:||.|..:.|.|.|:||:|||.|||:.|||..:.||.:...|:||||:.:.:..:|::
Worm  1154 EELGDRLDEAGGATQAQIELNKKREAELAKLRQDLEDAAINSETSMAALRKKHNDAVAELSDQLD 1218

  Fly   138 ILTKNKARAEKDKAKFQTEVYELLSQIESYNKEKIVSEKHISKLEVSISELNVKIEELNRTVIDI 202
            .:.|.:.:.|::|...|.||.||....:...|::...|:...:||..::::.:|.:|..|.:.::
Worm  1219 TIQKMRGKLEREKNDKQREVDELQQSADVEAKQRQNCERMAKQLEAQLTDMTLKSDEQARLIQEL 1283

  Fly   203 SSHRSRLSQENIELTKDVQDLKVQLDTVSFSKSQVISQLEDARRRLEDEDRRRSLLESSLHQVEI 267
            :..::::..||.:|.:.::|.:.||..::..|.|..||||:.:|.|:.|.|.|..|.|.:...::
Worm  1284 TMGKNKVHNENQDLNRQLEDAEAQLCALNRIKQQQHSQLEELKRTLDQETRERQSLHSQVSNYQL 1348

  Fly   268 ELDSVRNQLEEESEARIDLERQLVKANADATSWQNKWNSEVAARAEEVEEIRRKYQVRITELEEH 332
            |.:..|..||||.:|:.|::|||.|||::...|:.|:..|..:||||:||.|||...::.|::|.
Worm  1349 ECEQFRESLEEEQDAKTDVQRQLSKANSEIQQWRAKFEGEGVSRAEELEETRRKLTHKVQEMQEQ 1413

  Fly   333 IESLIVKVNNLEKMKTRLASEVEVLIIDLEKSNNSCRELTKSVNTLEKHNVELKSRLDETIILYE 397
            :|:...|:..|||.|.|||.::|...:|.:::|:....|.|.....:|...|.:.:.:..:...|
Worm  1414 LENANQKIGTLEKNKQRLAHDLEDAQVDADRANSIASSLEKKQKGFDKVLDEWRRKCEALVAEVE 1478

  Fly   398 TSQRDLKNKHADLVRTVHELDKVKDNNNQLTRENKKLGDDLHEAKGAINELNRRLHELELELRRL 462
            .|||:.:....:..|..::|::..:....:.||||.|..:|.:....:.|..:.:|:|:...|||
Worm  1479 QSQRETRAAATETFRLRNQLEESGEQTEAVKRENKALAQELKDIADQLGEGGKSVHDLQKMRRRL 1543

  Fly   463 ENERDELTAAYKEAEAGRKAEEQRGQRLAADFNQYRHDAERRLAEKDEEIEAIRKQTSIEIEQLN 527
            |.|::||..|..|||...:|||.:..|...:.:|.|.:.|:||.||:||.|..||..|..||.:.
Worm  1544 EIEKEELQQALDEAECALEAEEAKVMRAQIEVSQIRSEIEKRLQEKEEEFENTRKNHSRTIESMQ 1608

  Fly   528 ARVIEAETRLKTEVTRIKKKLQIQITELEMSLDVANKTNIDLQKVIKKQSLQLTELQAHYEDVQR 592
            .. :|.|:|.:.|:.:.||||:..:.|||::||.:||.|:|.||.:||....:.|||...|:.||
Worm  1609 VS-LETESRGRAELLKTKKKLEGDVNELEIALDHSNKLNVDGQKSMKKLQDTIRELQYQVEEEQR 1672

  Fly   593 QLQATLDQYAVAQRRLAGLNGELEEVRSHLDSANRAKRTVELQYEEAASRINELTTANVSLVSIK 657
            .|..:.|...:|:||...|..|.|::....:.:.|.:|..||:..|....:|||:.:|..|::.|
Worm  1673 SLSESRDHANLAERRSQVLQQEKEDLAIIYEQSERTRRQAELELAEVKDSVNELSNSNSLLLATK 1737

  Fly   658 SKLEQELSVVASDYEEVSKELRISDERYQKVQVELKHVVEQVHEEQERIVKLETIKKSLEVEVKN 722
            .|:|.:|.::.|:.||...:.:.|||:.:|..::...:.:::..|||....|...||:||.:||:
Worm  1738 RKVEGDLQLLQSEIEEAMSDAKTSDEKAKKAIMDASKLADELRSEQEHASNLNQSKKTLESQVKD 1802

  Fly   723 LSIRLEEVELNAVAGSKRIISKLEARIRDLELELEEEKRRHAETIKILRKKERTVKEVLVQCEED 787
            |.:||:|.|...:.|.||.::||:.||.:||.|||.|.||||||.|:||.|:|..:|:..|.:||
Worm  1803 LQMRLDEAEAAGIKGGKRQLAKLDMRIHELETELEGENRRHAETQKVLRNKDRKCRELQFQVDED 1867

  Fly   788 QKNLILLQDALDKSTAKINIYRRQLSEQEGVSQQTTTRVRRFQRELEAAEDRADTAESSLNIIRA 852
            :|:...:.|.::|...||..|:||:.:.|.::.....:.|:.|..:|.|::|||.||::|..:|.
Worm  1868 KKSQERMYDLIEKLQQKIKTYKRQIEDAESLASGNLAKYRQLQHVVEDAQERADAAENALQKLRL 1932

  Fly   853 KHRTFVTTSTV--PGSQVYIQETT 874
            |.|   :||.|  |....:...||
Worm  1933 KGR---STSGVFGPRGLAHSMSTT 1953

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prm	NP_523982.2	Myosin_tail_1	<34..853	CDD:279860	281/835 (34%)
myo-5	NP_505094.1	Myosin_N	31..68	CDD:280832
		Myosin_head	83..776	CDD:278492
		MYSc_class_II	95..776	CDD:276951
		Myosin_tail_1	853..1933	CDD:279860	284/844 (34%)
		DUF4795	954..1129	CDD:292662	9/39 (23%)
		Prefoldin	1111..1243	CDD:298833	42/131 (32%)
		Tmemb_cc2	<1212..1322	CDD:287269	25/109 (23%)
		DUF881	1746..>1838	CDD:303034	33/91 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810