DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prm and Myh11

DIOPT Version :9

Sequence 1:	NP_523982.2	Gene:	Prm / 39002	FlyBaseID:	FBgn0003149	Length:	879	Species:	Drosophila melanogaster
Sequence 2:	XP_006521906.1	Gene:	Myh11 / 17880	MGIID:	102643	Length:	1979	Species:	Mus musculus

Alignment Length:	883	Identity:	236/883 - (26%)
Similarity:	424/883 - (48%)	Gaps:	84/883 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 LSSLSRLEDKIRLLQDDLEVERELRQRIEREKADLSVQVIQMSERLEEAEGGAEHQFEANRKRDA 98
            |..:..||..|..||:||:.||..|.:.|::|.||..::..:...||:.......|.|...||:.
Mouse  1117 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQ 1181

  Fly    99 ELLKLRKLLEDVHLESEETTLLLKKKHNEIITDFQEQVEILTKNKARAEKDKAKFQTEVYELLSQ 163
            |:..|:|.|::.....|.....:::||.:.:.:..||:|...:.||..:|.|...:.|..:|..:
Mouse  1182 EVTVLKKALDEETRSHEAQVQEMRQKHTQAVEELTEQLEQFKRAKANLDKSKQTLEKENADLAGE 1246

  Fly   164 IESYNKEKIVSEKHISKLEVSISELNVKIEELNRTVIDISSHRSRLSQE--------------NI 214
            :....:.|...|....||||.:.:|..|..:..|...::|....:|..|              .|
Mouse  1247 LRVLGQAKQEVEHKKKKLEVQLQDLQSKCSDGERARAELSDKVHKLQNEVESVTGMLNEAEGKAI 1311

  Fly   215 ELTKDVQDLKVQLDTVSFSKSQVISQLEDARRRLEDEDRRRSLLESSLHQVEIELDSVRNQLEEE 279
            :|.|||..|.              |||:|.:..|::|.|::..:.:.|.|:|.|.:|:::||:||
Mouse  1312 KLAKDVASLG--------------SQLQDTQELLQEETRQKLNVSTKLRQLEDERNSLQDQLDEE 1362

  Fly   280 SEARIDLERQLVKANADATSWQNKWNSEVAARAEEVEEIRRKYQVRITELEEHIESLIVKVNNLE 344
            .||:.:|||.:...|...:..:.|. .:.|:..|.:||.:::.|..:..|.:..|......:.||
Mouse  1363 MEAKQNLERHVSTLNIQLSDSKKKL-QDFASTIEVMEEGKKRLQKEMEGLSQQYEEKAAAYDKLE 1426

  Fly   345 KMKTRLASEVEVLIIDLEKSNNSCRELTKSVNTLEKHNVELKSRLDETIILYETSQRDLKNKHAD 409
            |.|.||..|::.|::||:..    |:|   |:.|||...:....|.|        ::::.:|:||
Mouse  1427 KTKNRLQQELDDLVVDLDNQ----RQL---VSNLEKKQKKFDQLLAE--------EKNISSKYAD 1476

  Fly   410 ------------------LVRTVHELDKVKDNNNQLTRENKKLGDDLHEAKGAINELNRRLHELE 456
                              |.|.:.|..:.|:   :|.|.||.|..::.:...:.:::.:.:||||
Mouse  1477 ERDRAEAEAREKETKALSLARALEEALEAKE---ELERTNKMLKAEMEDLVSSKDDVGKNVHELE 1538

  Fly   457 LELRRLENERDELTAAYKEAEAGRKAEEQRGQRLAADFNQYRHDAERRLAEKDEEIEAIRKQTSI 521
            ...|.||.:.:|:....:|.|...:|.|....||..:....:...||.|..:||:.|..|:|...
Mouse  1539 KSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR 1603

  Fly   522 EIEQLNARVIEAETRLKTEVTRIKKKLQIQITELEMSLDVANKTNIDLQKVIKKQSLQLTELQAH 586
            ::.:.... :|.|.:.:......||||:..:.:||:..|.|.|..   ::.||    ||.:|||.
Mouse  1604 QLHEYETE-LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGR---EEAIK----QLRKLQAQ 1660

  Fly   587 YEDVQRQL---QATLDQ-YAVA---QRRLAGLNGELEEVRSHLDSANRAKRTVELQYEEAASRIN 644
            .:|.||:|   :|:.|: :|.:   :::...|..:|.:::..|.:|.||::..:|:.||.|..:.
Mouse  1661 MKDFQRELDDARASRDEIFATSKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1725

  Fly   645 ELTTANVSLVSIKSKLEQELSVVASDYEEVSKELRISDERYQKVQVELKHVVEQVHEEQERIVKL 709
            ...:...:|...|.:||..::.:..:.||....:....:|.:|..::.:.:..::..|:....|.
Mouse  1726 SSLSGRNTLQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATLQAEQLSNELATERSTAQKN 1790

  Fly   710 ETIKKSLEVEVKNLSIRLEEVELNAVAGSKRIISKLEARIRDLELELEEEKRRHAETIKILRKKE 774
            |:.::.||.:.|.|..:|:|||....|..|..::.|||:|..||.::|:|.|......|.|::|:
Mouse  1791 ESARQQLERQNKELRSKLQEVEGAVKAKLKSTVAALEAKIAQLEEQVEQEAREKQAATKSLKQKD 1855

  Fly   775 RTVKEVLVQCEEDQKNLILLQDALDKSTAKINIYRRQLSEQEGVSQQTTTRVRRFQRELEAAEDR 839
            :.:||||:|.|:::|.....::..:|...|:...:|||.|.|..||:.....|:.||||:.|.:.
Mouse  1856 KKLKEVLLQVEDERKMAEQYKEQAEKGNTKVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1920

  Fly   840 ADTAESSLNIIRAKHRTFVTTSTVP----GSQVYIQET 873
            .:.....:|.:::|.|.....|.||    |.:..|:.|
Mouse  1921 NEAMGREVNALKSKLRRGNEASFVPSRRAGGRRVIENT 1958

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prm	NP_523982.2	Myosin_tail_1	<34..853	CDD:279860	228/857 (27%)
Myh11	XP_006521906.1	Myosin_N	33..71	CDD:367160
		MYSc_class_II	99..778	CDD:276951
		Myosin_tail_1	855..1935	CDD:366712	228/858 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810