Protein Alignment Prm and Myh7

DIOPT Version :10

• Sequence 1: NP_523982.2
• Gene: Prm / 39002
• FlyBaseID: FBgn0003149
• Length: 879
• Species: Drosophila melanogaster
• Sequence 2: NP_542766.1
• Gene: Myh7 / 140781
• MGIID: 2155600
• Length: 1935
• Species: Mus musculus
• Alignment Length: 836
• Identity: 294/836 - (35%)
• Similarity: 500/836 - (59%)
• Gaps: 6/836 - (0%)

  Fly    25 DVNIEYIQDLSS-----LSRLEDKIRLLQDDLEVERELRQRIEREKADLSVQVIQMSERLEEAEG 84
            :..||..|.|.|     |..|:.:|..|:::||.||..|.::|:.::|||.::.::|||||||.|
Mouse  1091 NARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGG 1155

  Fly    85 GAEHQFEANRKRDAELLKLRKLLEDVHLESEETTLLLKKKHNEIITDFQEQVEILTKNKARAEKD 149
            ....|.|.|:||:||..|:|:.||:..|:.|.|...|:|||.:.:.:..||::.|.:.|.:.||:
Mouse  1156 ATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKE 1220

  Fly   150 KAKFQTEVYELLSQIESYNKEKIVSEKHISKLEVSISELNVKIEELNRTVIDISSHRSRLSQENI 214
            |::|:.|:.::.|.:|...|.|...||....||..::|...|.||..|:|.|::|.|::|..||.
Mouse  1221 KSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENG 1285

  Fly   215 ELTKDVQDLKVQLDTVSFSKSQVISQLEDARRRLEDEDRRRSLLESSLHQVEIELDSVRNQLEEE 279
            ||::.:.:.:..:..::..|.....||||.:|:||:|.:.::.|..:|.....:.|.:|.|.|||
Mouse  1286 ELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEE 1350

  Fly   280 SEARIDLERQLVKANADATSWQNKWNSEVAARAEEVEEIRRKYQVRITELEEHIESLIVKVNNLE 344
            :||:.:|:|.|.|||::...|:.|:.::...|.||:||.::|...|:.:.||.:|::..|.::||
Mouse  1351 TEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLE 1415

  Fly   345 KMKTRLASEVEVLIIDLEKSNNSCRELTKSVNTLEKHNVELKSRLDETIILYETSQRDLKNKHAD 409
            |.|.||.:|:|.|::|:|:||.:...|.|.....:|...|.|.:.:|:....|:||::.::...:
Mouse  1416 KTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTE 1480

  Fly   410 LVRTVHELDKVKDNNNQLTRENKKLGDDLHEAKGAINELNRRLHELELELRRLENERDELTAAYK 474
            |.:..:..::..::.....||||.|.:::.:....:....:.:||||...::||.|:.||.:|.:
Mouse  1481 LFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSTGKSIHELEKIRKQLEAEKLELQSALE 1545

  Fly   475 EAEAGRKAEEQRGQRLAADFNQYRHDAERRLAEKDEEIEAIRKQTSIEIEQLNARVIEAETRLKT 539
            ||||..:.||.:..|...:|||.:.:.||:|||||||:|..::.....::.|... ::||||.:.
Mouse  1546 EAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRMVDSLQTS-LDAETRSRN 1609

  Fly   540 EVTRIKKKLQIQITELEMSLDVANKTNIDLQKVIKKQSLQLTELQAHYEDVQRQLQATLDQYAVA 604
            |..|:|||::..:.|:|:.|..||:...:.||.:|.....|.:.|...:|..|......:..|:.
Mouse  1610 EALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV 1674

  Fly   605 QRRLAGLNGELEEVRSHLDSANRAKRTVELQYEEAASRINELTTANVSLVSIKSKLEQELSVVAS 669
            :||...|..||||:|:.::...|:::..|.:..|.:.|:..|.:.|.||::.|.|::.:||.:.:
Mouse  1675 ERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQT 1739

  Fly   670 DYEEVSKELRISDERYQKVQVELKHVVEQVHEEQERIVKLETIKKSLEVEVKNLSIRLEEVELNA 734
            :.||..:|.|.::|:.:|...:...:.|::.:||:....||.:||::|..:|:|..||:|.|..|
Mouse  1740 EVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIA 1804

  Fly   735 VAGSKRIISKLEARIRDLELELEEEKRRHAETIKILRKKERTVKEVLVQCEEDQKNLILLQDALD 799
            :.|.|:.:.|||||:|:||.|||.|::|:||::|.:||.||.:||:..|.|||:|||:.|||.:|
Mouse  1805 LKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVD 1869

  Fly   800 KSTAKINIYRRQLSEQEGVSQQTTTRVRRFQRELEAAEDRADTAESSLNIIRAKHR 855
            |...|:..|:||..|.|..:....::.|:.|.||:.||:|||.|||.:|.:|||.|
Mouse  1870 KLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSR 1925

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prm	NP_523982.2	Myosin_tail_1	<34..853	CDD:460256	288/823 (35%)
Myh7	NP_542766.1	COG5022	37..1432	CDD:227355	122/340 (36%)
		MYSc_class_II	99..766	CDD:276951
		Actin-binding	655..677
		Actin-binding	757..771
		SMC_prok_B	1173..1930	CDD:274008	261/754 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1915..1935		6/11 (55%)