Protein Alignment Prm and myo5a

DIOPT Version :10

• Sequence 1: NP_523982.2
• Gene: Prm / 39002
• FlyBaseID: FBgn0003149
• Length: 879
• Species: Drosophila melanogaster
• Sequence 2: XP_031755040.1
• Gene: myo5a / 100495365
• XenbaseID: XB-GENE-1004102
• Length: 1888
• Species: Xenopus tropicalis
• Alignment Length: 1103
• Identity: 236/1103 - (21%)
• Similarity: 416/1103 - (37%)
• Gaps: 370/1103 - (33%)

  Fly    28 IEYIQDLSSLSRLEDKIRLLQDDLEVERELRQ-RIEREKAD--------LSVQVIQMSERLEEAE 83
            :.|.::||::..|:...|.:.    .:|||:: :||....:        :..:::|:..:::|..
 Frog   883 VTYKRNLSAIVYLQCCYRRMM----AKRELKKLKIEARSVEHYKKLNNGMENKIMQLQRKVDEQN 943

  Fly    84 GGAEHQFEA--------NRKRDAELLKLRKLLEDV----HLESEETTLLLKKKHNEIITDFQEQV 136
            ...:...|.        |.::|       ||..||    |.|.|     .|...|.::: .|:::
 Frog   944 KDNKSLLERLTHLEVTYNTEKD-------KLRSDVDRLRHFEEE-----AKNAANRMVS-LQDEL 995

  Fly   137 EILTK--NKARAEKDK-----AKFQTEVYELLSQIESYN------KEKI------VSEKHISKLE 182
            ..|.|  .:.:.||:|     .|:|||..:|::::...|      ||::      .::|....:|
 Frog   996 ARLRKELQQTQTEKNKIEERAEKYQTETEKLVAELREQNALLKAEKEELNLLIQEQAKKMTEDME 1060

  Fly   183 VSISELNVKIEELNRTVIDISSHRSR---LSQENIELTKDVQDLKVQLDTVS------------- 231
            ..|      |||..:..::::..|.|   |..|...|.:...|||.:::|:|
 Frog  1061 KKI------IEETKQLELELNDERLRYQNLLNEYSRLEERYDDLKDEINTMSPPKPGHKRTDSTH 1119

  Fly   232 ------FSKSQVISQLEDARRRLEDEDRRRSLLESSLHQVEIELDSVRNQLEEESEA-RIDLERQ 289
                  ::.|..|::.||...|.|:...|::.|:.||.   ::|.....:||:|.:. :.||:::
 Frog  1120 SSNESEYTFSSEITESEDYPYRNEEPADRKTPLDMSLF---LKLQKRVKELEQEKQVMQDDLDKK 1181

  Fly   290 LVKANADATSWQNKWNSEVAARAEEVEEIRRKYQVRITELEEHIESLIVKVNNLEKMKTRLASEV 354
                            .|...||:.:||  .|...|.||||  .|||  |...||....:|.:|:
 Frog  1182 ----------------EEQIIRAKIMEE--AKTPTRGTELE--YESL--KRQELESENKKLKNEL 1224

  Fly   355 -EVLIIDLEKSNNSC--------RELTKSVNTLEKHNVELKSRLDETIILYE--TSQ------RD 402
             |:.....||::...        :.|.:.:.::.:   ||:.|.:|.:||..  .||      :|
 Frog  1225 NELRRAITEKASPDATGPGGTVYKVLLEQMTSVSE---ELEVRKEEVLILRSQLVSQMEAIPHKD 1286

  Fly   403 LKNKHADLVRTVHELDKVKD------------NNNQLTRENKKLGDDLHEAKGAINE-------- 447
            .|:...|.:....::.|:||            ..|.|....:.|..|..    |:||
 Frog  1287 DKDTMTDSMVLSEDVQKMKDKREIAQAYTGMKETNSLETIERNLPPDYQ----ALNEDGELWLVY 1347

  Fly   448 -----LNRRLH-ELELELRRLENERDELTAAYKEAEAGRKAEEQRGQRLAADFNQYRHDAERRLA 506
                 .||.|. :|:.:.:..|||.:.|..   |.:| .|.|..|.|:|.|...|...:| |..|
 Frog  1348 DGLKQANRVLESQLQSQKKAFENEVEALRG---EIQA-LKEENNRQQQLLAQNLQLPPEA-RIEA 1407

  Fly   507 EKDEEIEAIRKQTSIEIEQLNA---------------RVIEAETRLKTE---VTRIKKKLQI--- 550
            ....||..:..: ::..|:|.|               |:|:...:|:.:   |.::||:|::
 Frog  1408 SLQHEITRLTNE-NLFFEELYADEPMKYQSYRISLYRRIIDLMEQLEKQDKTVRKLKKQLKVFAK 1471

  Fly   551 QITELEMSLDVANKTNIDLQKVI-----------KKQSLQLTELQAHYED---VQRQLQATLDQY 601
            :|.|||    |....|:...:::           |::..| ..|:...||   :.:.|...|...
 Frog  1472 KIGELE----VGQMENVSPGQIVDEPIRPVNIPRKEKDFQ-GMLEYKKEDELKLVKNLILELKPR 1531

  Fly   602 AVAQRRLAGLNGEL--------------EEVRSHLDSA-NRAKR----------TVEL------- 634
            .||...:.||...:              ::|||.|.|. |..|:          ||..
 Frog  1532 GVAVNLIPGLPAYILFMCLRHADYLNDDQKVRSLLTSTINGIKKILKKRGDDFETVSFWLSNSCR 1596

  Fly   635 ------QY--EEA-----ASRINELTTANVSLVSIKSKLEQELSVVASDYEEVSKELRISDERYQ 686
                  ||  ||.     .:|.||....|..|               ::|.:|..:|.|  :.||
 Frog  1597 FLHCLKQYSGEEGFMKHNTTRQNEHCLTNFDL---------------AEYRQVLSDLAI--QIYQ 1644

  Fly   687 KVQVELKHVVEQV-------HE--------------------EQERIVKLETIKKSLE------- 717
            ::...|:::::.:       ||                    ..|....|::|.:.|.
 Frog  1645 QLVRVLENILQPMIVSGMLEHETIQGVSGVKPTGLRKRTSSIADEGTYTLDSIVRQLNTFHSIMC 1709

  Fly   718 ----------------------VEVKNLSIRLEEVELNAVAGSKRIISKLEARIRDLELELEEEK 760
                                  |.:.||.:|.:....:.....:..:|:||..:||..|.....|
 Frog  1710 QHGMDPELIKQVVKQMFYIIGAVTLNNLLLRKDMCSWSKGMQIRYNVSQLEEWLRDKNLMNSSAK 1774

  Fly   761 RRHAETI-------KILRKKERTVKEVLVQCEEDQKNLILLQDALDKSTAKI----NIYRRQLSE 814
                ||:       ::|:.|::|        :||.:.:..:.:||  :||:|    |:|......
 Frog  1775 ----ETLEPLIQAAQLLQVKKKT--------DEDAEAICSMCNAL--TTAQIVKVLNLYTPVNEF 1825

  Fly   815 QEGVSQQTTTRVRRFQRELEAAEDRADTAESSLNIIRAKHRTFVT-----------TSTVPGS 866
            :|.|   ..:.:|..|..|   .||.|:.:.   ::.|||...||           |..:|||
 Frog  1826 EERV---LVSFIRNIQMRL---RDRKDSPQL---LMDAKHIFPVTFPFNPSSLALETIQIPGS 1879

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prm	NP_523982.2	Myosin_tail_1	<34..853	CDD:460256	226/1071 (21%)
myo5a	XP_031755040.1	MYSc_Myo5	83..754	CDD:276831
		IQ	768..789	CDD:197470
		IQ	791..813	CDD:197470
		IQ	816..838	CDD:197470
		IQ	865..886	CDD:197470	0/2 (0%)
		SMC_prok_B	905..>1477	CDD:274008	143/628 (23%)
		Myo5a_CBD	1514..1888	CDD:271262	81/406 (20%)