DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment h and BHLHE41

DIOPT Version :9

Sequence 1:	NP_001014577.1	Gene:	h / 38995	FlyBaseID:	FBgn0001168	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	NP_110389.1	Gene:	BHLHE41 / 79365	HGNCID:	16617	Length:	482	Species:	Homo sapiens

Alignment Length:	320	Identity:	75/320 - (23%)
Similarity:	115/320 - (35%)	Gaps:	92/320 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LKETPLKSDRRSNKPIMEKRRRARINNCLNELKTLILDATKKDPARHSKLEKADILEKTVKHLQ- 86
            :|....|...:....::||:||.|||.|:.:||.|:.:..|.....|  ||||.:||.|:|||:
Human    36 MKRDDTKDTYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGH--LEKAVVLELTLKHLKA 98

  Fly    87 -----ELQRQQAAMQQAADPKI-------VNKFKAGFADCVNEV----SRFPGIEPAQRR--RLL 133
                 |.|.|:....|..:..:       ::.|.:||..|..||    |||....|.:.|  :|:
Human    99 LTALTEQQHQKIIALQNGERSLKSPIQSDLDAFHSGFQTCAKEVLQYLSRFESWTPREPRCVQLI 163

  Fly   134 QHLSNCINGVKTELHQQQRQQQQQSIHAQMLPSPPSSPEQ-DSQQGAAAPYLFGIQQTASGYFLP 197
            .||                    .::..|.||:|....:| ...:|..||...|  ..|:.....
Human   164 NHL--------------------HAVATQFLPTPQLLTQQVPLSKGTGAPSAAG--SAAAPCLER 206

  Fly   198 NGMQVIPTKLPNGSIALVLPQSLPQQQQQQLLQHQQQQQQLAV---------------------- 240
            .|.::.|       :|..:|          ::|..|...:||.
Human   207 AGQKLEP-------LAYCVP----------VIQRTQPSAELAAENDTDTDSGYGGEAEARPDREK 254

  Fly   241 --AAAAAAAAAAQQQPMLVSMPQRTASTGSASSHSSAGYESAPGSSSSCSYAP---PSPA 295
              .|.|:.....|:.|...|...:.....|....|..|    ||..::.:.|.   |.||
Human   255 GKGAGASRVTIKQEPPGEDSPAPKRMKLDSRGGGSGGG----PGGGAAAAAAALLGPDPA 310

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
h	NP_001014577.1	HLH	29..88	CDD:238036	24/64 (38%)
h	NP_001014577.1	ORANGE	106..141	CDD:128787	14/40 (35%)
BHLHE41	NP_110389.1	bHLH-O_DEC2	31..122	CDD:381593	29/87 (33%)
		Necessary for interaction with RXRA and repressor activity towards RXRA. /evidence=ECO:0000269\|PubMed:19786558	67..71		2/3 (67%)
		ORANGE	129..175	CDD:128787	15/65 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	228..298		12/73 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	438..482
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910