DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment h and hey1

DIOPT Version :9

Sequence 1:	NP_001014577.1	Gene:	h / 38995	FlyBaseID:	FBgn0001168	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	NP_997726.1	Gene:	hey1 / 58008	ZFINID:	ZDB-GENE-000607-70	Length:	317	Species:	Danio rerio

Alignment Length:	329	Identity:	89/329 - (27%)
Similarity:	131/329 - (39%)	Gaps:	93/329 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ANMTNVLGTAVVPAQLKETPLKSDRRSNKPIMEKRRRARINNCLNELKTLILDATKKDPARHSKL 72
            |...:.|| ::.|:...:...:..||.   |:|||||.||||.|:||:.|:..|.:|..:  :||
Zfish    29 AGANSPLG-SMSPSTTSQVQARKRRRG---IIEKRRRDRINNSLSELRRLVPSAFEKQGS--AKL 87

  Fly    73 EKADILEKTVKHLQELQRQQAAMQQAADPKIVNKFKA----------GFADCVNEVSRFPGI--- 124
            |||:||:.||.||:        |..||..|  ..|.|          ||.:|:.|.:|:..|
Zfish    88 EKAEILQMTVDHLK--------MLHAAGGK--GYFDAHALAMDYRGLGFRECLAETARYLSIIEG 142

  Fly   125 ----EPAQRRRLLQHLSNCINGVKTELHQ-----------------------QQRQQQQQSIHAQ 162
                :|. |.||:.||::..:  :.|.|.                       .|:||||.:..|:
Zfish   143 LDNTDPL-RIRLVSHLNSYAS--QREAHSGLGHLAWGSAFGTPPSHLAHHLLLQQQQQQGAPLAR 204

  Fly   163 MLPSPPSSPEQDSQQGAAAPYLFGIQQTASGYFLPNGMQVIPTKLPNGSIALVLPQSLPQQQQQQ 227
            ...|||||  ..|...:::|.....:...||..:....|..|.::|..:       |||
Zfish   205 STSSPPSS--NSSSPSSSSPSAPSTEPRLSGTVISEAGQTGPLRVPPST-------SLP------ 254

  Fly   228 LLQHQQQQQQLAVAAAAAAAAAAQQQPMLVSMPQRTA-----STGSASSHSSAGYESAPGSSSSC 287
                         .......|:....|:|.|:...:|     |.....|.||.| .:.|.||...
Zfish   255 -------------PGLTPPTASKLSPPLLTSLSSLSAFPFPLSAFPLLSPSSLG-PATPSSSLGK 305

  Fly   288 SYAP 291
            .|.|
Zfish   306 PYRP 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
h	NP_001014577.1	HLH	29..88	CDD:238036	29/58 (50%)
h	NP_001014577.1	ORANGE	106..141	CDD:128787	14/51 (27%)
hey1	NP_997726.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..59		8/33 (24%)
		HLH	49..106	CDD:238036	30/69 (43%)
		ORANGE	119..165	CDD:128787	12/48 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	193..264		22/98 (22%)
		YRPW motif	307..310		2/3 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810