DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment h and HES6

DIOPT Version :9

Sequence 1:	NP_001014577.1	Gene:	h / 38995	FlyBaseID:	FBgn0001168	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	NP_061115.2	Gene:	HES6 / 55502	HGNCID:	18254	Length:	224	Species:	Homo sapiens

Alignment Length:	158	Identity:	48/158 - (30%)
Similarity:	76/158 - (48%)	Gaps:	17/158 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 KSDRRSNKPIMEKRRRARINNCLNELKTLILDATKKDPARHSKLEKADILEKTVKHLQELQRQQA 93
            :.||::.||::||:||||||..|.||:.|:..|..:     :|||.|::||.||:.:|.:.|.:|
Human    23 RGDRKARKPLVEKKRRARINESLQELRLLLAGAEVQ-----AKLENAEVLELTVRRVQGVLRGRA 82

  Fly    94 AMQQAADPKIVNKFKAGFADCVNEVSRF----PGIEPAQRRRLLQHLSNCINGVKTELHQQQRQQ 154
            ..::....:...:|.||:..|::||..|    ..|:......||.||        .|....:...
Human    83 REREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDATVAAELLNHL--------LESMPLREGS 139

  Fly   155 QQQSIHAQMLPSPPSSPEQDSQQGAAAP 182
            ..|.:....|..||.:|.:.......||
Human   140 SFQDLLGDALAGPPRAPGRSGWPAGGAP 167

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
h	NP_001014577.1	HLH	29..88	CDD:238036	26/58 (45%)
h	NP_001014577.1	ORANGE	106..141	CDD:128787	12/38 (32%)
HES6	NP_061115.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31		2/7 (29%)
		HLH	23..75	CDD:238036	25/56 (45%)
		Hairy_orange	96..134	CDD:311465	13/45 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	147..205		6/21 (29%)
		WRPW motif	221..224
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810