DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment h and hes4

DIOPT Version :9

Sequence 1:	NP_001014577.1	Gene:	h / 38995	FlyBaseID:	FBgn0001168	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	NP_988870.1	Gene:	hes4 / 394465	XenbaseID:	XB-GENE-487830	Length:	281	Species:	Xenopus tropicalis

Alignment Length:	334	Identity:	113/334 - (33%)
Similarity:	151/334 - (45%)	Gaps:	80/334 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 AVVPAQLKETPLK-----SDRRSNKPIMEKRRRARINNCLNELKTLILDATKKDPARHSKLEKAD 76
            |..||...:||.|     ..|:|:|||||||||||||..|.:||||||||.|||.:|||||||||
Frog    15 AGAPASSAQTPDKPKSASEHRKSSKPIMEKRRRARINESLGQLKTLILDALKKDSSRHSKLEKAD 79

  Fly    77 ILEKTVKHLQELQRQQAAMQQAADPKIVNKFKAGFADCVNEVSRF----PGIEPAQRRRLLQHLS 137
            |||.|||||:.|||.|......|||.::.|::|||.:|:|||:||    .|:....|.|||.|||
Frog    80 ILEMTVKHLRNLQRVQMTAALTADPSVLGKYRAGFNECMNEVTRFLSTCEGVNTEVRTRLLGHLS 144

  Fly   138 NCINGVKTELHQQQRQQQQQSIHAQM---LPSPPSSPEQDSQQGAAAPYLFGIQQTASGYFLPNG 199
            :|: |....::.||....||.:|.|:   .|:|...|.:.:...|.:|.:|           ..|
Frog   145 SCL-GQIVAMNYQQPPSSQQPLHVQLPSSTPAPVPMPCKVNPAEAISPKVF-----------QGG 197

  Fly   200 MQVIPTKLPNGSIALVLPQSLPQQQQQQLLQHQQQQQQLAVAAAAAAAAAAQQQPMLVSMPQRTA 264
            .|::|.  .:|..|.::|.                                         |..|.
Frog   198 FQLVPA--TDGQFAFLIPN-----------------------------------------PAYTT 219

  Fly   265 STGSASSHSSAGYESAPGSSSSCSYAPPSPANSSYEPMDIKPSVIQRVPMEQQPLS-LVIKKQIK 328
            |.|......:....::||...|.|            |:....:...::|...|.:| |.......
Frog   220 SPGPVIPLYANTNVTSPGGPQSQS------------PVQGLTTFGHKMPHMAQAVSPLGGSTGAD 272

  Fly   329 EEEQPWRPW 337
            ..|..||||
Frog   273 SAESVWRPW 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
h	NP_001014577.1	HLH	29..88	CDD:238036	45/63 (71%)
h	NP_001014577.1	ORANGE	106..141	CDD:128787	19/38 (50%)
hes4	NP_988870.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44		12/28 (43%)
		bHLH-O_HES1_4	33..95	CDD:381465	47/61 (77%)
		Hairy_orange	110..147	CDD:369405	17/36 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	262..281		5/18 (28%)
		WRPW motif. /evidence=ECO:0000255	278..281		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	92	1.000	Domainoid score	I7479
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H137824
Inparanoid	1	1.050	156	1.000	Inparanoid score	I4193
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1427802at2759
OrthoFinder	1	1.000	-	-		FOG0000785
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3450
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.070