Protein Alignment hry and HES3

DIOPT Version :10

• Sequence 1: NP_523977.2
• Gene: hry / 38995
• FlyBaseID: FBgn0001168
• Length: 337
• Species: Drosophila melanogaster
• Sequence 2: NP_001019769.1
• Gene: HES3 / 390992
• HGNCID: 26226
• Length: 186
• Species: Homo sapiens
• Alignment Length: 303
• Identity: 74/303 - (24%)
• Similarity: 99/303 - (32%)
• Gaps: 129/303 - (42%)

  Fly    39 MEKRRRARINNCLNELKTLILDATKKDPARHSKLEKADILEKTVKHLQELQRQQAAM----QQAA 99
            |||:||||||..|.:||:| |:.......|..|||||||||.:||:::.||.....:    :.|.
Human     1 MEKKRRARINVSLEQLKSL-LEKHYSHQIRKRKLEKADILELSVKYMRSLQNSLQGLWPVPRGAE 64

  Fly   100 DPKIVNKFKAGFADCVNEVSRFPGIEPAQRRRLLQHLSNCINGVKTELHQQQRQQQQQSIHAQML 164
            .|       :||..|:      ||:....||                     ..:....:...::
Human    65 QP-------SGFRSCL------PGVSQLLRR---------------------GDEVGSGLRCPLV 95

  Fly   165 PSPPSSPEQDSQQGAAAPYLFGIQQTASGYFLPNGMQVIPTKLPNGSIALVLPQSLPQQQQQQLL 229
            |...:....||.         |:.|.|...|.|                     ..|
Human    96 PESAAGSTMDSA---------GLGQEAPALFRP---------------------CTP-------- 122

  Fly   230 QHQQQQQQLAVAAAAAAAAAAQQQPMLVSMPQRTASTGSASSHSSAGYESAPGSSSSCSYAPPSP 294
                     ||.|.|.||...:..|.|:.:|                 ||.||||:  |..||.|
Human   123 ---------AVWAPAPAAGGPRSPPPLLLLP-----------------ESLPGSSA--SVPPPQP 159

  Fly   295 ANSSYEPMDIKPSVIQRVPMEQQPLSLVIKKQIKEEEQPWRPW 337
            |:|..              .|...|.|.:          ||||
Human   160 ASSRC--------------AESPGLGLRV----------WRPW 178

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hry	NP_523977.2	bHLH-O_hairy_like	30..88	CDD:381483	26/48 (54%)
		ORANGE	106..141	CDD:128787	7/34 (21%)
HES3	NP_001019769.1	bHLH-O_HES3	1..55	CDD:381503	28/54 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	128..186		25/94 (27%)
		WRPW motif	175..178		2/2 (100%)