DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment h and heyl

DIOPT Version :9

Sequence 1:	NP_001014577.1	Gene:	h / 38995	FlyBaseID:	FBgn0001168	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	NP_859425.1	Gene:	heyl / 335134	ZFINID:	ZDB-GENE-030131-7074	Length:	310	Species:	Danio rerio

Alignment Length:	279	Identity:	86/279 - (30%)
Similarity:	122/279 - (43%)	Gaps:	52/279 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 RRSNKPIMEKRRRARINNCLNELKTLILDATKKDPARHSKLEKADILEKTVKHLQELQRQQAAMQ 96
            |:..:.|:|||||.|||:.|:||:.|:..|.:|..:  ||||||:||:.||.||:.|........
Zfish    44 RKKRRGIIEKRRRDRINHSLSELRRLVPSAFEKQGS--SKLEKAEILQMTVDHLKLLHAMGGKGY 106

  Fly    97 QAADPKIVNKFKAGFADCVNEVSRF----PGIEPAQ--RRRLLQHLSNCINGVKTELHQQQRQQQ 155
            ..|....|:....||.:||.||.|:    .|:|.:.  ..||:.|||:|.:.:...|
Zfish   107 FDARALAVDYRTLGFRECVGEVVRYLSSLEGVESSDPIGARLVSHLSHCASELDPLL-------- 163

  Fly   156 QQSIHAQMLPSPPSSPEQDSQQGAAAPYLFGIQQTASGYFLPNGMQVIPTKLPNGSIALVLPQSL 220
             ||..|  ||.||.......|..||:|      ..:|..|.||..:.:   .|:|: |.:|....
Zfish   164 -QSPAA--LPFPPWPWASFPQLQAASP------PASSTPFPPNARRDL---TPHGT-ATILGYPS 215

  Fly   221 PQQQQQQLLQHQQQQQQLAVAAAAAAAAAAQQQPMLVSMPQRTASTG---SASSHSSAGYESAPG 282
            |                 |:...:.:.......|.|.|:.|..:..|   ....||..| .:.|.
Zfish   216 P-----------------ALRMGSLSTQGTILNPALTSVRQLPSVPGHLHRLQQHSPEG-RTVPS 262

  Fly   283 SSSSCSYAPPSPANSSYEP 301
            ||||.|.:  ||...|:.|
Zfish   263 SSSSSSNS--SPPQISFRP 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
h	NP_001014577.1	HLH	29..88	CDD:238036	28/55 (51%)
h	NP_001014577.1	ORANGE	106..141	CDD:128787	15/40 (38%)
heyl	NP_859425.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		HLH	44..101	CDD:238036	29/58 (50%)
		ORANGE	115..159	CDD:128787	15/43 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..208		9/35 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	248..310		13/35 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	3	2.770