DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment h and HEYL

DIOPT Version :9

Sequence 1:NP_001014577.1 Gene:h / 38995 FlyBaseID:FBgn0001168 Length:337 Species:Drosophila melanogaster
Sequence 2:NP_055386.2 Gene:HEYL / 26508 HGNCID:4882 Length:328 Species:Homo sapiens


Alignment Length:318 Identity:86/318 - (27%)
Similarity:133/318 - (41%) Gaps:89/318 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 TPLKSD---RRSNKPIMEKRRRARINNCLNELKTLILDATKKDPARHSKLEKADILEKTVKHLQE 87
            ||..|.   |:.::.|:|||||.|||:.|:||:.|:..|.:|..:  ||||||::|:.||.||:.
Human    35 TPSSSQMQARKKHRGIIEKRRRDRINSSLSELRRLVPTAFEKQGS--SKLEKAEVLQMTVDHLKM 97

  Fly    88 LQRQQAAMQQAADPKIVNKFKAGFADCVNEVSRFPGI--------EPAQRRRLLQHLSNCINGVK 144
            |..........|....|:....||.:|:.||.|:.|:        :|. |.|||.||:       
Human    98 LHATGGTGFFDARALAVDFRSIGFRECLTEVIRYLGVLEGPSSRADPV-RIRLLSHLN------- 154

  Fly   145 TELHQQQRQQQQQSIHAQMLPSP-------------------PSSPEQDSQQG----AAAPYLFG 186
                         |..|:|.|||                   |..|...:|..    ..:|.|.|
Human   155 -------------SYAAEMEPSPTPTGPLAFPAWPWSFFHSCPGLPALSNQLAILGRVPSPVLPG 206

  Fly   187 IQQTASGYFLPNGMQVIPTKLPNGSIALVLPQSLPQQQQQQLLQHQQQQQQLAVAAAAAAAAAAQ 251
            :...|  |.:| .::..|.:...|.|       ||.::.              |..:..|::..:
Human   207 VSSPA--YPIP-ALRTAPLRRATGII-------LPARRN--------------VLPSRGASSTRR 247

  Fly   252 QQPM---LVSMPQRTASTGSASSHSSAGYESA----PGSSSSCSY-APPSPANSSYEP 301
            .:|:   ...:|...:|..:.|||.:...:|:    ||.:.|.:| |.|:|.:||..|
Human   248 ARPLERPATPVPVAPSSRAARSSHIAPLLQSSSPTPPGPTGSAAYVAVPTPNSSSPGP 305

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hNP_001014577.1 HLH 29..88 CDD:238036 28/61 (46%)
ORANGE 106..141 CDD:128787 14/42 (33%)
HEYLNP_055386.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..57 9/21 (43%)
Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000250 42..111 29/70 (41%)
HLH 42..100 CDD:238036 28/59 (47%)
ORANGE 115..162 CDD:128787 17/67 (25%)
Atrophin-1 <136..311 CDD:331285 46/215 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 239..308 18/67 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165140968
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4304
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.740

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