Protein Alignment h and HEY1

DIOPT Version :9

• Sequence 1: NP_001014577.1
• Gene: h / 38995
• FlyBaseID: FBgn0001168
• Length: 337
• Species: Drosophila melanogaster
• Sequence 2: NP_001035798.1
• Gene: HEY1 / 23462
• HGNCID: 4880
• Length: 308
• Species: Homo sapiens
• Alignment Length: 370
• Identity: 84/370 - (22%)
• Similarity: 130/370 - (35%)
• Gaps: 140/370 - (37%)

  Fly     9 NMTNVLGTAVVPAQLKETPLKSD----RRSNKPIMEKRRRARINNCLNELKTLILDATKKDPARH 69
            |:::.||:.        :|..|.    |:..:.|:|||||.||||.|:||:.|:..|.:|.....
Human    31 NLSSALGSM--------SPTTSSQILARKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQVMEQ 87

  Fly    70 --SKLEKADILEKTVKHLQELQRQQAAMQQAADPKIVNKFKAGFADCVNEVSRF----PGIEPAQ 128
              :|||||:||:.||.||:.|..........|....::....||.:|:.||:|:    .|::.:.
Human    88 GSAKLEKAEILQMTVDHLKMLHTAGGKGYFDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASD 152

  Fly   129 --RRRLLQHLSNCINGVKTELHQQQRQ-------------------QQQQSIHAQMLP------- 165
              |.||:.||:|         :..||:                   ......|..:||
Human   153 PLRVRLVSHLNN---------YASQREAASGAHAGLGHIPWGTVFGHHPHIAHPLLLPQNGHGNA 208

  Fly   166 ---SPPSSPEQDSQQGAAAPYLFGIQQTASGYFLPNGMQVIPTKLPNGSIALVLPQSLPQQQQQQ 227
               :.|:.|....:.|:|.|       .|.....|          |:||:..|||
Human   209 GTTASPTEPHHQGRLGSAHP-------EAPALRAP----------PSGSLGPVLP---------- 246

  Fly   228 LLQHQQQQQQLAVAAAAAAAAAAQQQPMLVSMPQRTASTGSASSHSSAGYESAPGSSSSCSYAPP 292
                             ...:|::..|.|:|              |.|...:.|.|..|.....|
Human   247 -----------------VVTSASKLSPPLLS--------------SVASLSAFPFSFGSFHLLSP 280

  Fly   293 SPANSSYEPMDIKPSVIQRVPMEQQPLSLVIKKQIKEEEQPWRPW 337
            :.         :.||    .|.:...|.           :|:|||
Human   281 NA---------LSPS----APTQAANLG-----------KPYRPW 301

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
h	NP_001014577.1	HLH	29..88	CDD:238036	29/64 (45%)
		ORANGE	106..141	CDD:128787	13/40 (33%)
HEY1	NP_001035798.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..52		6/28 (21%)
		bHLH_SF	41..126	CDD:381792	32/84 (38%)
		ORANGE	124..170	CDD:128787	14/54 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	200..238		9/54 (17%)
		YRPW motif	298..301		1/2 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810