DRSC/TRiP Functional Genomics Resources

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Protein Alignment h and Hey2

DIOPT Version :9

Sequence 1:NP_001014577.1 Gene:h / 38995 FlyBaseID:FBgn0001168 Length:337 Species:Drosophila melanogaster
Sequence 2:NP_038932.1 Gene:Hey2 / 15214 MGIID:1341884 Length:339 Species:Mus musculus


Alignment Length:340 Identity:92/340 - (27%)
Similarity:143/340 - (42%) Gaps:69/340 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 VTAANMTNVLGTAVVPAQLKETPLKSD----RRSNKPIMEKRRRARINNCLNELKTLILDATKKD 65
            :...:..|..|.|........:|..:.    |:..:.|:|||||.||||.|:||:.|:..|.:|.
Mouse    18 IDVGSENNYPGHATSSVMRSNSPTTTSQIMARKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQ 82

  Fly    66 PARHSKLEKADILEKTVKHLQELQRQQAAMQQAADPKIVNKFKAGFADCVNEVSRF----PGIEP 126
            .:  :|||||:||:.||.||:.||.........|.....:....||.:|:.||:|:    .|::|
Mouse    83 GS--AKLEKAEILQMTVDHLKMLQATGGKGYFDAHALATDFMSIGFRECLTEVARYLSSVEGLDP 145

  Fly   127 AQ--RRRLLQHLSNCINGVKTELHQQQRQQQQQSIH-------------AQMLP-------SPP- 168
            :.  |.||:.|||.|.:..:..:...........:|             |.:.|       |.| 
Mouse   146 SDPLRVRLVSHLSTCASQREAAVMTSSMAHHHHPLHPHHWAAAFHHLPTALLQPNGLHTSESTPC 210

  Fly   169 ---SSPEQDSQQGAA---APYLFGIQQTASGYFLPNGMQVIPTKLPNGSIALVLPQSLPQQQQQQ 227
               :|.|..|..|:|   |.:    ....|...:|:|..|.|...|..:..|.|..::       
Mouse   211 RLSTSSEVPSAHGSALLTATF----AHADSALRMPSGGTVAPCVPPLSTSLLSLSATV------- 264

  Fly   228 LLQHQQQQQQLAVAAAAAAAAAAQQQPMLV--SMPQRTASTGSASSHSSAGYESAPGSSSSCSYA 290
               |         ||||||.|||...|:..  :.|...::..:|::.::|...|.|.|.|:.| :
Mouse   265 ---H---------AAAAAATAAAHSFPLSFAGAFPMLPSNAAAAAAVAAATAISPPLSVSAAS-S 316

  Fly   291 PPSPA----NSSYEP 301
            |...:    |..|:|
Mouse   317 PQQTSTGTNNKPYQP 331

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hNP_001014577.1 HLH 29..88 CDD:238036 28/62 (45%)
ORANGE 106..141 CDD:128787 15/40 (38%)
Hey2NP_038932.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..52 5/33 (15%)
Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000269|PubMed:11486045 47..116 31/70 (44%)
HLH 49..105 CDD:238036 29/57 (51%)
ORANGE 120..165 CDD:128787 15/44 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 310..339 7/23 (30%)
YQPW motif 329..332 2/3 (67%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4304
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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