DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pex7 and HAT2

DIOPT Version :9

Sequence 1:	NP_001137914.1	Gene:	Pex7 / 38994	FlyBaseID:	FBgn0035922	Length:	339	Species:	Drosophila melanogaster
Sequence 2:	NP_010858.3	Gene:	HAT2 / 856654	SGDID:	S000000782	Length:	401	Species:	Saccharomyces cerevisiae

Alignment Length:	365	Identity:	79/365 - (21%)
Similarity:	137/365 - (37%)	Gaps:	88/365 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 THTTTDRHGYSLRFSPFEANYLLLATSQLYGLAGGGSLFLLEQNSNTNSSSTDGQSLGELCRLEW 69
            |||:.:...| |:|:.......:|:.......||         ....:|......::....:.|.
Yeast    63 THTSGEEENY-LKFAEINLPKEILSNEDPQEEAG---------EEYQSSLPAPRSNIRITAKYEH 117

  Fly    70 SDGLFDVAWCPYAADIAATASGDGSLQIWCGLDGESASNQLTPKQPLICLQEHKNEVYSLDWGEK 134
            .:.:....:.|...:|.||.:|.|::.::...:|..::           |:.||:..|:|
Yeast   118 EEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQST-----------LKFHKDNGYAL----- 166

  Fly   135 WNYHT-----LLSGSWDCTLKLWDCNRQNSITTFVG-----HNDLIYGAKFSPLIANLFASVSTD 189
             ::.|     |||||.|.|:.||:.......|..|.     |:|:|...|:.....:||.:||.|
Yeast   167 -SFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSED 230

  Fly   190 GHLNL------------------WNSLDFAGKPLMSIEAHASEALCCDWSHFDRNVLVTGGSDGL 236
            ..|.:                  :|:|.|                    ||...|:|...|.|..
Yeast   231 SLLKINDVRANNTTIDTVKCPQPFNTLAF--------------------SHHSSNLLAAAGMDSY 275

  Fly   237 IRGWDLRKMRTHVFELYSGEFAVRRLACSPHSAAVLASANYDFTTRIWNLER------GESAQE- 294
            :..:|||.|:..:..:...|.||..|..|.|...|:.|:..|....:|:|::      .:.|::
Yeast   276 VYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDG 340

  Fly   295 ------VNARHTEFVCGLDWNPHRTHQLADCGWDSLANVY 328
                  |:|.|...|...|.||.....:|....:::..|:
Yeast   341 VPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVW 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pex7	NP_001137914.1	WD40	53..328	CDD:295369	69/315 (22%)
		WD40 repeat	74..121	CDD:293791	8/46 (17%)
		WD40	<85..>328	CDD:225201	66/283 (23%)
		WD40 repeat	126..164	CDD:293791	13/42 (31%)
		WD40 repeat	171..209	CDD:293791	10/55 (18%)
		WD40 repeat	215..251	CDD:293791	10/35 (29%)
		WD40 repeat	259..296	CDD:293791	10/49 (20%)
		WD40 repeat	303..328	CDD:293791	5/24 (21%)
HAT2	NP_010858.3	CAF1C_H4-bd	12..82	CDD:403473	6/19 (32%)
		WD40	<116..401	CDD:225201	69/302 (23%)
		WD40 repeat	122..158	CDD:293791	8/46 (17%)
		WD40 repeat	163..204	CDD:293791	14/46 (30%)
		WD40 repeat	212..247	CDD:293791	7/34 (21%)
		WD40 repeat	254..292	CDD:293791	13/57 (23%)
		WD40 repeat	298..349	CDD:293791	11/50 (22%)
		WD40 repeat	355..380	CDD:293791	5/24 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344762
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840