DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pex7 and PEX7

DIOPT Version :9

Sequence 1:	NP_001137914.1	Gene:	Pex7 / 38994	FlyBaseID:	FBgn0035922	Length:	339	Species:	Drosophila melanogaster
Sequence 2:	NP_010426.1	Gene:	PEX7 / 851720	SGDID:	S000002549	Length:	375	Species:	Saccharomyces cerevisiae

Alignment Length:	379	Identity:	109/379 - (28%)
Similarity:	168/379 - (44%)	Gaps:	93/379 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 GYSLRFSPFEANYLLLATSQLYGLAGGGSLFLLEQNSN-----TNSSSTDGQSLGELCRLEWSDG 72
            ||.:::|||..|.|.:|....:||.|.|.||:||.:.:     .||..|             .|.
Yeast    11 GYGVQYSPFFDNRLAVAAGSNFGLVGNGKLFILEIDRSGRIVEVNSFLT-------------QDC 62

  Fly    73 LFDVAWCPYAADIAATASGDGSLQIWCGLDGESASNQLTPKQ-PLICLQEHKNEVYSLDWGEKWN 136
            |||:||.....:....|.|||:|:::          ..|.|: |:...:||:.||:|.:| ...|
Yeast    63 LFDLAWNESHENQVLVAQGDGTLRLF----------DTTFKEFPIAIFKEHEREVFSCNW-NLVN 116

  Fly   137 YHTLLSGSWDCTLKLWDCNRQNSITT------------------------FVG---HNDLIYGAK 174
            ....||.|||.::|:|...|:.|:.|                        |.|   :.:.:|.|:
Yeast   117 RQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQ 181

  Fly   175 FSPLIANLFASVSTDGHLNLWNSLDFAGKPLMSIEAHAS-EALCCDWSHFDRNVLVTGGSDGLIR 238
            |||...||..|.|.:.:.:|::....:||...:...|:. |||.||::.:...|:.|||.|..||
Yeast   182 FSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIR 246

  Fly   239 GWDLRKM---------RTHVFELYSGE----------FAVRRLACSPHSAAVLASANYDFTTRIW 284
            .||:|.:         ||...:|::..          .|:|::..|||.:.:|.||:||.|.|||
Yeast   247 IWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIW 311

  Fly   285 NLERGESAQEVN---------------ARHTEFVCGLDWNP-HRTHQLADCGWD 322
            .....:.|:|..               .:|:|||.|.||:. .:...:|...||
Yeast   312 RDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWD 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pex7	NP_001137914.1	WD40	53..328	CDD:295369	92/334 (28%)
		WD40 repeat	74..121	CDD:293791	12/47 (26%)
		WD40	<85..>328	CDD:225201	84/302 (28%)
		WD40 repeat	126..164	CDD:293791	14/61 (23%)
		WD40 repeat	171..209	CDD:293791	12/37 (32%)
		WD40 repeat	215..251	CDD:293791	16/44 (36%)
		WD40 repeat	259..296	CDD:293791	15/36 (42%)
		WD40 repeat	303..328	CDD:293791	7/21 (33%)
PEX7	NP_010426.1	WD40 repeat	11..55	CDD:293791	16/43 (37%)
		WD40 repeat	65..102	CDD:293791	11/46 (24%)
		WD40	<71..372	CDD:421866	84/306 (27%)
		WD40 repeat	107..144	CDD:293791	14/37 (38%)
		WD40 repeat	152..214	CDD:293791	14/61 (23%)
		WD40 repeat	221..270	CDD:293791	17/48 (35%)
		WD40 repeat	286..339	CDD:293791	15/52 (29%)
		WD40 repeat	345..371	CDD:293791	7/21 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	48	1.000	Domainoid score	I3001
eggNOG	1	0.900	-	-		E1_KOG0277
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	133	1.000	Inparanoid score	I1230
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53887
OrthoFinder	1	1.000	-	-		FOG0006273
OrthoInspector	1	1.000	-	-		oto99437
orthoMCL	1	0.900	-	-		OOG6_102912
Panther	1	1.100	-	-	LDO	PTHR46027
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R904
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.860