DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pex7 and PEX7

DIOPT Version :9

Sequence 1:	NP_001137914.1	Gene:	Pex7 / 38994	FlyBaseID:	FBgn0035922	Length:	339	Species:	Drosophila melanogaster
Sequence 2:	NP_000279.1	Gene:	PEX7 / 5191	HGNCID:	8860	Length:	323	Species:	Homo sapiens

Alignment Length:	327	Identity:	141/327 - (43%)
Similarity:	185/327 - (56%)	Gaps:	20/327 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 TTDRHGYSLRFSPFEANYLLLATSQLYGLAGGGSLFLLEQNSNTNSSSTDGQSLGELCRLEWSDG 72
            |..||||:..|||:....|..||:|.||:||.|:|.:|:         .|...|......:|:||
Human    14 TPGRHGYAAEFSPYLPGRLACATAQHYGIAGCGTLLILD---------PDEAGLRLFRSFDWNDG 69

  Fly    73 LFDVAWCPYAADIAATASGDGSLQIWCGLDGESASNQLTPKQPLICLQEHKNEVYSLDWGEKWNY 137
            ||||.|......:..|.|||||||:|   |...|:.      ||...:||..||||:||.:....
Human    70 LFDVTWSENNEHVLITCSGDGSLQLW---DTAKAAG------PLQVYKEHAQEVYSVDWSQTRGE 125

  Fly   138 HTLLSGSWDCTLKLWDCNRQNSITTFVGHNDLIYGAKFSPLIANLFASVSTDGHLNLWNSLDFAG 202
            ..::|||||.|:||||.....|:.||.||..:||...:||.|...|||.|.|..|.:|: :..||
Human   126 QLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWD-VKAAG 189

  Fly   203 KPLMSIEAHASEALCCDWSHFDRNVLVTGGSDGLIRGWDLRKMRTHVFELYSGEFAVRRLACSPH 267
            ..:: |.||.:|.|.|||..::.|:||||..|..:||||||.:|..||||....:|:||:..||.
Human   190 VRIV-IPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPF 253

  Fly   268 SAAVLASANYDFTTRIWNLERGESAQEVNARHTEFVCGLDWNPHRTHQLADCGWDSLANVYTPQC 332
            .|:||||.:||||.|.||..:.:|..|....||||.||||::.....|:|||.||....:|.|.|
Human   254 HASVLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQSPTQVADCSWDETIKIYDPAC 318

  Fly   333 LS 334
            |:
Human   319 LT 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pex7	NP_001137914.1	WD40	53..328	CDD:295369	118/274 (43%)
		WD40 repeat	74..121	CDD:293791	17/46 (37%)
		WD40	<85..>328	CDD:225201	108/242 (45%)
		WD40 repeat	126..164	CDD:293791	17/37 (46%)
		WD40 repeat	171..209	CDD:293791	13/37 (35%)
		WD40 repeat	215..251	CDD:293791	18/35 (51%)
		WD40 repeat	259..296	CDD:293791	18/36 (50%)
		WD40 repeat	303..328	CDD:293791	10/24 (42%)
PEX7	NP_000279.1	WD 1	65..96		17/33 (52%)
		WD40	68..315	CDD:238121	115/257 (45%)
		WD40 repeat	70..109	CDD:293791	18/47 (38%)
		WD 2	109..141		16/31 (52%)
		WD40 repeat	115..153	CDD:293791	17/37 (46%)
		WD 3	153..184		13/30 (43%)
		WD40 repeat	158..195	CDD:293791	14/38 (37%)
		WD 4	196..227		15/30 (50%)
		WD40 repeat	202..239	CDD:293791	20/36 (56%)
		WD 5	240..271		15/30 (50%)
		WD40 repeat	245..283	CDD:293791	18/37 (49%)
		WD 6	284..315		14/30 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141601
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0277
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H242
Inparanoid	1	1.050	264	1.000	Inparanoid score	I3081
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53887
OrthoDB	1	1.010	-	-		D350307at33208
OrthoFinder	1	1.000	-	-		FOG0006273
OrthoInspector	1	1.000	-	-		oto89527
orthoMCL	1	0.900	-	-		OOG6_102912
Panther	1	1.100	-	-	LDO	PTHR46027
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R904
SonicParanoid	1	1.000	-	-		X5222
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800