DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arr2 and arrb1

DIOPT Version :9

Sequence 1:	NP_523976.1	Gene:	Arr2 / 38993	FlyBaseID:	FBgn0000121	Length:	401	Species:	Drosophila melanogaster
Sequence 2:	NP_001153294.1	Gene:	arrb1 / 553266	ZFINID:	ZDB-GENE-060824-1	Length:	418	Species:	Danio rerio

Alignment Length:	404	Identity:	173/404 - (42%)
Similarity:	258/404 - (63%)	Gaps:	29/404 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KVFKKATPNGKVTFYLGRRDFIDHIDYCDPVDGVIVVEPDYLKNRKVFGQLATTYRYGREEDEVM 70
            :|||||:||||:|.|||:|||:||:|..:|||||::::|:|||.||||..|...:|||||:.:|:
Zfish     7 RVFKKASPNGKLTVYLGKRDFVDHVDLVEPVDGVVLIDPEYLKERKVFVTLTCAFRYGREDLDVL 71

  Fly    71 GVKFSKELILCREQ-IVPMTNPNMEMTPMQEKLVRKLGSNAYPFTFHFPPNSPSSVTLQQEGDDN 134
            |:.|.|:|.:...| ..|:......:|.:||:|::|||.:||||||..|||.|.|||||...:|.
Zfish    72 GLTFRKDLFVANIQAFPPVPEEKKSLTRLQERLIKKLGEHAYPFTFEIPPNLPCSVTLQPGPEDT 136

  Fly   135 GKPLGVEYTIRAFVGDSEDDRQHKRSMVSLVIKKLQYAPLNRGQRLPSSLVSKGFTFSNGKISLE 199
            ||..||::.::||..::.:::.|||:.|.|||:|:||||...|.: |.:..::.|..|:..:.||
Zfish   137 GKACGVDFEVKAFCAENVEEKIHKRNSVRLVIRKVQYAPEKPGPQ-PMAETTRQFLMSDKPLHLE 200

  Fly   200 VTLDREIYYHGEKTAATVQVSNNSKKSVKSIKCFIVQHTEITMVN-AQFSKHVAQLETKEGCPIT 263
            .:||:|||||||..:..|.|:||:.|:||.||..:.|:.:|.:.| ||:...||..|:.:  .:.
Zfish   201 ASLDKEIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYADICLFNTAQYKCPVAIEESDD--IVA 263

  Fly   264 PGANLTKTFYLIPLAANNKDRHGIALDGHLKDEDVNLASSTMVQEGKSTGDACGIVISYSVRIKL 328
            |.|...|.:.|.|..|||:::.|:||||.||.||.||||||:::|| :..:..||::||.|::||
Zfish   264 PSATFCKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTLLREG-ANKEILGIIVSYKVKVKL 327

  Fly   329 ---NCGTLGGEMQTDV----PFKLLQPAPGTIEKK------RSNAMKKMKSIEQHRNVKGYYQDD 380
               ..|.||....:||    ||.|:.|.|  :|:.      .::|......||        :..:
Zfish   328 VVSRGGLLGDLASSDVAVELPFTLMHPKP--LEESIYRDAPENDAPIDTNLIE--------FDTN 382

  Fly   381 DDNIVFEDFAKMRM 394
            ||:|:|||||:.|:
Zfish   383 DDDIIFEDFARQRL 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arr2	NP_523976.1	Arrestin_N	17..172	CDD:278754	74/155 (48%)
Arr2	NP_523976.1	Arrestin_C	192..350	CDD:214976	70/165 (42%)
arrb1	NP_001153294.1	Arrestin_N	18..174	CDD:278754	74/155 (48%)
arrb1	NP_001153294.1	Arrestin_C	193..356	CDD:214976	70/165 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52566
OrthoDB	1	1.010	-	-		D340461at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11792
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.030