DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arr2 and Arrb2

DIOPT Version :9

Sequence 1:	NP_523976.1	Gene:	Arr2 / 38993	FlyBaseID:	FBgn0000121	Length:	401	Species:	Drosophila melanogaster
Sequence 2:	NP_037043.1	Gene:	Arrb2 / 25388	RGDID:	2157	Length:	410	Species:	Rattus norvegicus

Alignment Length:	403	Identity:	174/403 - (43%)
Similarity:	263/403 - (65%)	Gaps:	13/403 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KVFKKATPNGKVTFYLGRRDFIDHIDYCDPVDGVIVVEPDYLKNRKVFGQLATTYRYGREEDEVM 70
            :||||::||.|:|.|||:|||:||:|..||||||::|:|||||:||||..|...:|||||:.:|:
  Rat     8 RVFKKSSPNCKLTVYLGKRDFVDHLDKVDPVDGVVLVDPDYLKDRKVFVTLTCAFRYGREDLDVL 72

  Fly    71 GVKFSKELILCREQ-IVPMTNPNMEMTPMQEKLVRKLGSNAYPFTFHFPPNSPSSVTLQQEGDDN 134
            |:.|.|:|.:...| ..||.||....|.:|::|::|||.:|:||.|..|.|.|.|||||...:|.
  Rat    73 GLSFRKDLFIATYQAFPPMPNPPRPPTRLQDRLLKKLGQHAHPFFFTIPQNLPCSVTLQPGPEDT 137

  Fly   135 GKPLGVEYTIRAFVGDSEDDRQHKRSMVSLVIKKLQYAPLNRGQRLPSSLVSKGFTFSNGK-ISL 198
            ||..||::.||||...|.:::.|||:.|.|:|:|:|:||...|.: ||:..::.|..|:.: :.|
  Rat   138 GKACGVDFEIRAFCAKSIEEKSHKRNSVRLIIRKVQFAPETPGPQ-PSAETTRHFLMSDRRSLHL 201

  Fly   199 EVTLDREIYYHGEKTAATVQVSNNSKKSVKSIKCFIVQHTEITMVN-AQFSKHVAQLETKEGCPI 262
            |.:||:|:|||||.....|.|:|||.|:||.|:..:.|:.:|.:.: ||:...|||||..:  .:
  Rat   202 EASLDKELYYHGEPLNVNVHVTNNSAKTVKKIRVSVRQYADICLFSTAQYKCPVAQLEQDD--QV 264

  Fly   263 TPGANLTKTFYLIPLAANNKDRHGIALDGHLKDEDVNLASSTMVQEGKSTGDACGIVISYSVRIK 327
            :|.:...|.:.:.||.::|:::.|:||||.||.||.||||||:|:|| :..:..||::||.|::|
  Rat   265 SPSSTFCKVYTITPLLSDNREKRGLALDGQLKHEDTNLASSTIVKEG-ANKEVLGILVSYRVKVK 328

  Fly   328 LNCGTLGGEMQTDVPFKLLQPAP-GTIEKKRSNAMKKMKSIEQHRNVKGY---YQDDDDNIVFED 388
            | ..:.||::..::||.|:.|.| ..|...|..:..:...|....|:..:   |..||| |||||
  Rat   329 L-VVSRGGDVSVELPFVLMHPKPHDHITLPRPQSAPREIDIPVDTNLIEFDTNYATDDD-IVFED 391

  Fly   389 FAKMRMNNVNMAD 401
            ||::|:..:...|
  Rat   392 FARLRLKGMKDDD 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arr2	NP_523976.1	Arrestin_N	17..172	CDD:278754	78/155 (50%)
Arr2	NP_523976.1	Arrestin_C	192..350	CDD:214976	65/159 (41%)
Arrb2	NP_037043.1	Arrestin_N	19..175	CDD:278754	78/155 (50%)
		Arrestin_C	199..350	CDD:214976	64/154 (42%)
		Interaction with TRAF6. /evidence=ECO:0000250	241..410		62/169 (37%)
		Interaction with AP2B1	378..410		13/28 (46%)
		[DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. /evidence=ECO:0000250	386..396		8/10 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3865
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52566
OrthoDB	1	1.010	-	-		D340461at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11792
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.930