DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arr2 and Sag

DIOPT Version :9

Sequence 1:	NP_523976.1	Gene:	Arr2 / 38993	FlyBaseID:	FBgn0000121	Length:	401	Species:	Drosophila melanogaster
Sequence 2:	NP_033144.1	Gene:	Sag / 20215	MGIID:	98227	Length:	403	Species:	Mus musculus

Alignment Length:	399	Identity:	159/399 - (39%)
Similarity:	242/399 - (60%)	Gaps:	34/399 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VFKKATPNGKVTFYLGRRDFIDHIDYCDPVDGVIVVEPDYLKNRKVFGQLATTYRYGREEDEVMG 71
            :|||.:.:..||.|||:||::||:...:|||||::|:|:.:|.:||:..|...:|||:|:.:|||
Mouse    13 IFKKVSRDKSVTIYLGKRDYVDHVSQVEPVDGVVLVDPELVKGKKVYVTLTCAFRYGQEDIDVMG 77

  Fly    72 VKFSKELILCREQIVPMTNPNMEMTPMQEKLVRKLGSNAYPFTFHFPPNSPSSVTLQQEGDDNGK 136
            :.|.::|...|.|:.|.......:|.:||.|::|||.|.|||...||...|.||.||....|.||
Mouse    78 LTFRRDLYFSRVQVYPPVGAMSVLTQLQESLLKKLGDNTYPFLLTFPDYLPCSVMLQPAPQDVGK 142

  Fly   137 PLGVEYTIRAF---VGDSEDDRQHKRSMVSLVIKKLQYAPLNRGQRLPSSLVSKGFTFSNGKISL 198
            ..||::.::||   :.|.|:|:..|:|.|.|:|:|:|:||...|.: ||:..|..|..|:..::|
Mouse   143 SCGVDFEVKAFASDITDPEEDKIPKKSSVRLLIRKVQHAPPEMGPQ-PSAEASWQFFMSDKPLNL 206

  Fly   199 EVTLDREIYYHGEKTAATVQVSNNSKKSVKSIKCFIVQHTEITMVNAQ-FSKHVAQLETKEGCPI 262
            .|:|.:|||:|||....||.|:||:.|.||.||..:.|...:.:.::. :.|.||..||:|  .:
Mouse   207 SVSLSKEIYFHGEPIPVTVTVTNNTDKVVKKIKVSVEQIANVVLYSSDYYVKPVASEETQE--KV 269

  Fly   263 TPGANLTKTFYLIPLAANNKDRHGIALDGHLKDEDVNLASSTMVQEGKSTGDACGIVISYSVRIK 327
            .|.:.||||..|:||.|||::|.||||||.:|.||.||||||:::||... ...||::||.:::|
Mouse   270 QPNSTLTKTLVLVPLLANNRERRGIALDGKIKHEDTNLASSTIIKEGIDR-TVMGILVSYHIKVK 333

  Fly   328 LN-CGTLG----GEMQTDVPFKLLQPAPGTIEKKRSNAMKKMKSIEQHRNVKGYYQDDDDNIVFE 387
            |. .|.||    .|:.|:|||:|:.|.|....|         :|::            |:|:|||
Mouse   334 LTVSGFLGELTSSEVATEVPFRLMHPQPEDPAK---------ESVQ------------DENLVFE 377

  Fly   388 DFAKMRMNN 396
            :||:..:.:
Mouse   378 EFARQNLKD 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arr2	NP_523976.1	Arrestin_N	17..172	CDD:278754	67/157 (43%)
Arr2	NP_523976.1	Arrestin_C	192..350	CDD:214976	72/163 (44%)
Sag	NP_033144.1	Interaction with RHO. /evidence=ECO:0000269\|PubMed:28753425	11..19		3/5 (60%)
		Arrestin_N	23..181	CDD:334019	67/157 (43%)
		Arrestin_C	200..361	CDD:214976	72/163 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	381..403		0/6 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3865
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52566
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11792
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920