DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arr2 and arr-1

DIOPT Version :9

Sequence 1:	NP_523976.1	Gene:	Arr2 / 38993	FlyBaseID:	FBgn0000121	Length:	401	Species:	Drosophila melanogaster
Sequence 2:	NP_508183.1	Gene:	arr-1 / 180446	WormBaseID:	WBGene00000195	Length:	435	Species:	Caenorhabditis elegans

Alignment Length:	418	Identity:	174/418 - (41%)
Similarity:	264/418 - (63%)	Gaps:	28/418 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KVFKKATPNGKVTFYLGRRDFIDHIDYCDPVDGVIVVEPDYLK-NRKVFGQLATTYRYGREEDEV 69
            :||||.:||||:|.|||:|||||..||.|.:||:::::.:|:| ||||...|...:|||||:.:|
Worm    11 RVFKKTSPNGKITTYLGKRDFIDRGDYVDLIDGMVLIDEEYIKDNRKVTAHLLAAFRYGREDLDV 75

  Fly    70 MGVKFSKELILCREQIVPMTNPNME--MTPMQEKLVRKLGSNAYPFTFHFPPNSPSSVTLQQEGD 132
            :|:.|.|:||....|:.|.|:.::.  ::.:||:|.||||:||:||.|...|.|.||||||....
Worm    76 LGLTFRKDLISETFQVYPQTDKSISRPLSRLQERLKRKLGANAFPFWFEVAPKSASSVTLQPAPG 140

  Fly   133 DNGKPLGVEYTIRAFVG--DSEDDRQHKRSMVS----LVIKKLQYAPL-NRGQRLPSSLVSKGFT 190
            |.|||.||:|.::.||.  |.....:.|:|.:|    |.|:||.|||. :|.|  |...|||.|.
Worm   141 DTGKPCGVDYELKTFVAVTDGSSGEKPKKSALSNTVRLAIRKLTYAPFESRPQ--PMVDVSKYFM 203

  Fly   191 FSNGKISLEVTLDREIYYHGEKTAATVQVSNNSKKSVKSIKCFIVQHTEITM-VNAQFSKHVAQL 254
            .|:|.:.:||:||:|:|||||..:..|.:.|||.|:||.:|.:|:|..:|.: ..|.:|..||::
Worm   204 MSSGLLHMEVSLDKEMYYHGESISVNVHIQNNSNKTVKKLKIYIIQVADICLFTTASYSCEVARI 268

  Fly   255 ETKEGCPITPGANLTKTFYLIPLAANNKDRHGIALDGHLKDEDVNLASSTMVQEGKSTGDACGIV 319
            |:.||.|:.||..|:|.|.:.||.:||||:.|:||||.||.||.||||||:: :.|::.::.|||
Worm   269 ESNEGFPVGPGGTLSKVFAVCPLLSNNKDKRGLALDGQLKHEDTNLASSTIL-DSKTSKESLGIV 332

  Fly   320 ISYSVRIKLNCGTLGGEMQTDVPFKLLQPAPGTIEKKRSNAMKKMKS-----------IEQHRNV 373
            :.|.|:::...|.|.||:..::||.|....|....::....:..:::           |:.|..:
Worm   333 VQYRVKVRAVLGPLNGELFAELPFTLTHSKPPESPERTDRGLPSIEATNGSEPVDIDLIQLHEEL 397

  Fly   374 KGYYQDDDDNIVFEDFAKMRMNNVNMAD 401
            :..|   ||:::|||||:||::..:..|
Worm   398 EPRY---DDDLIFEDFARMRLHGNDSED 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arr2	NP_523976.1	Arrestin_N	17..172	CDD:278754	72/163 (44%)
Arr2	NP_523976.1	Arrestin_C	192..350	CDD:214976	70/158 (44%)
arr-1	NP_508183.1	Arrestin_N	22..186	CDD:278754	72/163 (44%)
arr-1	NP_508183.1	Arrestin_C	205..363	CDD:214976	70/158 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3865
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.802101	Normalized mean entropy	S2648
OMA	1	1.010	-	-		QHG52566
OrthoDB	1	1.010	-	-		D340461at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11792
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.880