DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment AFF3 and lilli

DIOPT Version :9

Sequence 1:XP_024308651.1 Gene:AFF3 / 3899 HGNCID:6473 Length:1380 Species:Homo sapiens
Sequence 2:NP_001137775.1 Gene:lilli / 33496 FlyBaseID:FBgn0041111 Length:1673 Species:Drosophila melanogaster


Alignment Length:1731 Identity:369/1731 - (21%)
Similarity:582/1731 - (33%) Gaps:575/1731 - (33%)


- Green bases have known domain annotations that are detailed below.


Human   131 DSFDLALLQEWDLESLWGE-DILNQRNDSLVVEFQSSASRCRSVYEPDRNALRRKERERRNQETQ 194
            :|..:.|||:...:....: |.|.|.|::|.     |.:.....||      |||.|||...|.|
  Fly    24 NSSSIVLLQQQQPQQQQQQLDQLQQYNNNLY-----SQNYNMEEYE------RRKRREREKIERQ 77

Human   195 QDDGTFNSSYSLFSEPYKTNKGDELSNRIQNTLGNYDEMKDFLTDRSNQSHLVGV----PKPGVP 255
            |.....:...|||.||.:..:||.   .|...||.:.|.::::   :||:  ||:    |..|.|
  Fly    78 QGIQIDDRETSLFGEPRRLTEGDA---EITAALGEFFEAREYI---NNQT--VGISRSAPGAGNP 134

Human   256 Q-----TPVNKIDEHFVADSRAQNQPSSICSTTTSTPAAVP-VQQSKR---------------GT 299
            :     .|..|...|..:.:.:...|:: .|.|||.|.... .||.:|               |.
  Fly   135 RLQPNLAPQAKSLGHSPSSASSAAGPTA-ASATTSLPGQQQHYQQQQRPPTYVKQADNKPPYNGR 198

Human   300 MGW----------QKAGHPPSDGQQRATQQGS---------------LRTLLGDGVGRQQPRAKQ 339
            .|:          ..:|..|..|..|.:...|               ..|.||..:..|.|..::
  Fly   199 GGYPGQPMKNDIPSSSGMAPPRGPPRTSSSNSNSSSVTNNASSGGVPASTPLGPPLSTQMPNGRE 263

Human   340 VCNVEVGLQTQERPPAMAAKHSSSGHCVQNFPPSLASKPSLVQQKPTA---------------YV 389
                    ::...|||.|..:.:.|..|   ||:.:.:|.:.||.|..               .|
  Fly   264 --------KSFLGPPAPALHNGTGGRFV---PPAASKRPGVGQQPPPPEKDVNKIISDIANIFTV 317

Human   390 RPMDGQDQAPDESPKLKSSSETSVHCTSY-RGVPASKP--EPARAKAKL---------SKFSIPK 442
            :|:......| .:|..::.:..:.:...| ..:|:|.|  ||:.....|         ...:.|.
  Fly   318 QPLTLIAATP-HAPTRENYNLLAPNRQKYAMDIPSSPPSAEPSSLMTPLFAPITSPIAPLVTTPP 381

Human   443 QGEESRSGETNS---CVEEIIREMTWLPP-----LSAIQAPGKVEPTK----FPFPNKDSQLVS- 494
            |..:...|...|   ...|.:..:..|||     .|.:.:||.|:|.|    .....:||.|.: 
  Fly   382 QASQMPLGGATSGTILAGEALAPLHQLPPTMPKAASGVTSPGPVKPLKTEKNHSLEKQDSCLEND 446

Human   495 ----------------SGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEEN----EQQAAQ 539
                            ||.|:  ...:|.:|.::|:.::|  ::||:...:.:::    :||..|
  Fly   447 LELSESEDEQRKKEGRSGGNS--SNSSESDSSESGSESSS--KNDLQHHPNHQQHHHQLQQQQQQ 507

Human   540 RTALRALSDSAVVQQ-------------------------PNCRTSVPSSKGSSSSSSSGSSSSS 579
            :.|  .:....|:||                         .|..|.:.||.|..|..:.|.:..:
  Fly   508 QQA--TMQQQQVLQQQHRSQPLTSNGAQNKKFRHEIIARGSNTITGLLSSSGFGSGGNVGPAGVN 570

Human   580 SDSESSSGSDSETESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLNK---------VNPHK-- 633
            |::...:||.|....||..|..:|.|       .|..||||.|.::.:|         |:|..  
  Fly   571 SNAVVGTGSGSGGTLSSGGSSSNKTP-------SPTESNKWNLSRFFHKPANQTNSESVSPGNVS 628

Human   634 ---PPIL-----------------IQNESH------GSESN-------QY-----YNPVKEDVQD 660
               |.||                 ::||.:      |.|.:       :|     ..||....:.
  Fly   629 MKVPGILPGGAQIIPESIDVTTAIVKNEKNDMAMEEGEEEDDDEEQQLRYGGGLSVTPVAVKKEA 693

Human   661 CGKVPDVCQPSLREKEIK----STCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPP--- 718
            ...|.::...::.:.:||    .|....:...:...|.||......|..:|:...|.....|   
  Fly   694 IDAVSEMALGAIPKTQIKRESAETLLSARLSDSGTSASGSSSSSSSSSDSAMGGEVVPMPGPGET 758

Human   719 ---PAVPCA--------PAENAPAPARRSA---------------GKKPTRRTERTSA------- 750
               |.||.|        |.::..||...|.               .|||.::...|||       
  Fly   759 LQLPGVPAAITTVMRVQPTQSQKAPPSNSVTLTPILPLPTSPKQRQKKPRKKKAITSAPILDSSD 823

Human   751 ----------------------------------------GDGANCHRPEEPAAADALGTSVVVP 775
                                                    |...|.......:::...|.::...
  Fly   824 DDEPPPKHPGLDHTAVSVQTQPATDTVKKGRGRPRKQQQSGGSGNLSSASAGSSSQTKGPTLTAA 888

Human   776 PEPTKTRPCGNNRASHRKELRSSV----TCEKR---------------RTRGLSRIVPKSKEFIE 821
            .:|....|...:||..|:....|.    |..|:               .|.|.|.....|....|
  Fly   889 KKPLAKTPLAMSRARKREHSSQSSSNGNTPTKKVATPQLVAAPLKPTSNTAGSSSSDEDSSSSAE 953

Human   822 TESSSSSSSSDSDLESEQEE-----YPLSKA-------------------------QTVAASASS 856
            :.|.||||||.|| ::|.:.     ..|:|.                         ||..:...|
  Fly   954 SSSKSSSSSSSSD-DTETQNTNCRIVKLNKTGAVQKKALLGSGSSSPSSSGSEAEDQTTRSQVGS 1017

Human   857 G-----------------NDQRLKEAAANGGSG-------------------------PRAPVGS 879
            |                 :.|.|..:..:..||                         |::....
  Fly  1018 GQALAQQLPPYKQLPISQHSQHLSSSDCSSSSGGCTAVCSSSSGEEDEGRREKERERKPKSDKNK 1082

Human   880 INARTTSDIAKE--------------LEEQFY--------------------------TLVPFGR 904
            ||..|.....||              .|||..                          .:.|..:
  Fly  1083 INTLTRIFNPKEGGAKKQGQVVIVDLQEEQQQGKLDAAAQPSAPQAPPAAPAAIMAKPRMTPTQQ 1147

Human   905 NE----LLSPLK-DSDEIRSLWVKIDLTLLSR------------------IPE-------HLPQE 939
            .:    |.||.: .:..:.||..||||:.|||                  .|:       |:|..
  Fly  1148 QQLGAGLASPARTTTPHLTSLICKIDLSKLSRERIMRLKKLTPAQQNGHLTPKDQATNAVHVPNG 1212

Human   940 PGVLSAPATKDSESAP--PSHTSDTPAE-KALP-----------------KSKRKRKCDNEDDYR 984
            ....:.||.|.....|  |....|...| |..|                 :.:|:|:.:.|.| |
  Fly  1213 YAGDTNPAAKVKHEHPVKPEPELDAGYEAKFKPGNVKQEFQLKQERDRDRERERERERERERD-R 1276

Human   985 EIKKSQGEK------DSSSRLATSTSNTLSANHCNMNINSVAIPI----NKNEKMLRSPISPLSD 1039
            |.::..|.:      .|||...........|:...|....:.:|:    |.:|:|   |......
  Fly  1277 EREQPPGRRRKRSSSSSSSPYKEKKRKKEKADQLQMGKELLPVPVLLPSNNHERM---PNHDRLS 1338

Human  1040 ASKHKYTSED----LTSSSRPNGNSLFTSASSSKKPKADSQLQPHGGDLTKAAHNNSENIPLHKS 1100
            ..|.:...||    :...|.|||       |.:||..|.|.|.| ...:|.|....:|.:     
  Fly  1339 YDKLQLLHEDAAAVIGDVSAPNG-------SPTKKLLAMSPLPP-PPTVTVAPATCNEAV----- 1390

Human  1101 RPQTKPWSPGSNG-----------------HRDCKRQKLVFDDMPRSADYFMQEAKRMKHKADAM 1148
              ||.|.|..:..                 .||.:..    .|.||..:.|:|||...||.||..
  Fly  1391 --QTTPPSATATSAIAPPVPATRLIYRSYFDRDVEHP----SDDPRKNNQFLQEAINRKHAADLE 1449

Human  1149 VEKFGKALNYAEAALSFIECGNAMEQGPMESKSPYTMYSETVELIRY-AMRLKTHSGPNAT---- 1208
            .:.|.:...|.||.:.|:...:|||:...| ::..|||.:|:.||:: :.:.:.:...:.|    
  Fly  1450 RDSFNQVTLYLEAVVYFLLTADAMERCSSE-QATNTMYKDTLSLIKFISTKFRPYQQQSTTNIQH 1513

Human  1209 PEDKQLAALCYRCLALLYWRMFRLKRDHAVKYSKALIDYFKNSSKAAQAPSPWGASGKSTG-TPS 1272
            ....::|.|..||.:|:..::::|:|........:|.|:|:           .|....:.| |||
  Fly  1514 ETHNKVAILSLRCQSLISLKLYKLRRKDCRAIINSLTDFFR-----------VGRGDIANGNTPS 1567

Human  1273 PMSPNPSPASSVGSQGSLSNASALSPSTIVSIPQRIHQMAANHVSITNSILHSYDYWEMADNLAK 1337
            .:    ||::|||||||.||.   .|..||  |..||.|........:.:..:::.|:.||.|.:
  Fly  1568 SI----SPSNSVGSQGSGSNT---PPGRIV--PPDIHNMLCKQNEFLSYLNSAHELWDQADRLVR 1623

Human  1338 ENR--EFFNDLDLLMGPVTLHSSMEHLVQYSQQGLHWLRNS 1376
            ...  :|..:||...||:||||:|..:.:|.|.||..||::
  Fly  1624 TGNHIDFIRELDHENGPLTLHSTMHEVFRYVQAGLKTLRDA 1664

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AFF3XP_024308651.1 AF-4 177..1374 CDD:310000 355/1680 (21%)
lilliNP_001137775.1 AF-4 <1435..1662 CDD:282905 75/247 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165147716
Domainoid 1 1.000 131 1.000 Domainoid score I5139
eggNOG 1 0.900 - - E1_28IRS
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 155 1.000 Inparanoid score I4312
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001371
OrthoInspector 1 1.000 - - otm41726
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR10528
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
87.980

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