DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cdc6 and ORC1

DIOPT Version :10

Sequence 1:NP_648247.1 Gene:Cdc6 / 38989 FlyBaseID:FBgn0035918 Length:662 Species:Drosophila melanogaster
Sequence 2:NP_004144.2 Gene:ORC1 / 4998 HGNCID:8487 Length:861 Species:Homo sapiens


Alignment Length:721 Identity:173/721 - (23%)
Similarity:302/721 - (41%) Gaps:153/721 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 STRLSSISKATAASPLPPSTQTPRRSEVWKRRQPKK------VLADSDEEEEVVTAIYDLTSPVS 65
            |...:|.|:.|...||.|..:  :|.|:.....|:.      ...||....:...|..::|||  
Human   214 SRHSASKSRQTPTHPLTPRAR--KRLELGNLGNPQMSQQTSCASLDSPGRIKRKVAFSEITSP-- 274

  Fly    66 ENNENRNVLNKMDKISRRRTSQVQVAQSELP--KTPRSTKKTVQSAGSSRAKREEEN------RE 122
                           |:|  ||....|:..|  |.|..|::|..|......|...|:      |.
Human   275 ---------------SKR--SQPDKLQTLSPALKAPEKTRETGLSYTEDDKKASPEHRIILRTRI 322

  Fly   123 ATARFLEGEQDSEVDPLHGSPPKQRKLQPLPQHLISPSRLLDRLSIDERQEEEVEATTH------ 181
            |.::.::..::..:.|:.|.    ::...:|..::.|..:..|.:.:.:.:.|..:|.|      
Human   323 AASKTIDIREERTLTPISGG----QRSSVVPSVILKPENIKKRDAKEAKAQNEATSTPHRIRRKS 383

  Fly   182 ------------------KTETAEQQ--PKHQAKDEAKPRPKQQEDPLAQKQQEKPPTKQPNKNQ 226
                              |::..|::  |..:..|.:....:....||.::   .|.|...|. :
Human   384 SVLTMNRIRQQLRFLGNSKSDQEEKEILPAAEISDSSSDEEEASTPPLPRR---APRTVSRNL-R 444

  Fly   227 TKEKSNIQTNEETQQNNL-PSPSR-----------------NKYQNAR-RVLNSAETQNLPGRES 272
            :..||::.|..:..:.:| |...|                 :..:.|| |:..||..::||.||.
Human   445 SSLKSSLHTLTKVPKKSLKPRTPRCAAPQIRSRSLAAQEPASVLEEARLRLHVSAVPESLPCREQ 509

  Fly   273 QLQELREFFSNHLESQTSGSLYVSGQPGTGKTACLSLLLR----------DPDFSKRLQRVYINC 327
            :.|::..|..:.|...|.|.:|:||.|||||||.:..::|          .|.|    |.:.:|.
Human   510 EFQDIYNFVESKLLDHTGGCMYISGVPGTGKTATVHEVIRCLQQAAQANDVPPF----QYIEVNG 570

  Fly   328 TSIASVGAVYKKLCTELQLKVSGR--TERDHLEAIQRHLKT---AKRMLLLVLDEIDQLCTSRQE 387
            ..:.....||.::   || |::|:  |.....|.:.:...|   .:...:|::||:|.|.|.:|:
Human   571 MKLTEPHQVYVQI---LQ-KLTGQKATANHAAELLAKQFCTRGSPQETTVLLVDELDLLWTHKQD 631

  Fly   388 VLYTIFEWPALPGSRILLVGIANSLDLTDRALM-RLNARCELKPRLMHFPPYSKQQIVEIFKSRL 451
            ::|.:|:||....:|::::.|||::||.:|.:| |:::|..|  ..|.|.||:..|:.:|.:|||
Human   632 IMYNLFDWPTHKEARLVVLAIANTMDLPERIMMNRVSSRLGL--TRMCFQPYTYSQLQQILRSRL 694

  Fly   452 AEAEVLDVFPPVTLQLLAAKVSAISGDVRRALDIGRRVVEIAE--QQKRDGEKEFNMKALQLEGK 514
            ..   |..|....:||:|.||:|:|||.||.|||.||..||.|  |||.|......: |..:|..
Human   695 KH---LKAFEDDAIQLVARKVAALSGDARRCLDICRRATEICEFSQQKPDSPGLVTI-AHSMEAV 755

  Fly   515 DAVEAKEKQDTLKPVQVTQVAAVLNKVYGASQNLEEDIEASFPLQQKLMLCTLVLMLRNERNKDI 579
            |.:.:.           :.:.|:.|         ...:|.||          |..:|...|...:
Human   756 DEMFSS-----------SYITAIKN---------SSVLEQSF----------LRAILAEFRRSGL 790

  Fly   580 SMGRLHEVYRRVCAKRNILALDQAEFTGTVDLVETRGILRIMRKKEPR---LHKVLLQWDEEEVH 641
            ......::|.:..|...:..|.....:.|:.:....|..|::..:..|   |.:|.|...:::|.
Human   791 EEATFQQIYSQHVALCRMEGLPYPTMSETMAVCSHLGSCRLLLVEPSRNDLLLRVRLNVSQDDVL 855

  Fly   642 AALSDK 647
            .||.|:
Human   856 YALKDE 861

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cdc6NP_648247.1 CDC6 256..646 CDD:441083 117/411 (28%)
ORC1NP_004144.2 BAH_Orc1p_animal 44..170 CDD:240070
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 183..233 7/18 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 269..312 15/61 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 360..382 4/21 (19%)
rne <362..>487 CDD:236766 18/128 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 412..476 13/67 (19%)
PTZ00112 <495..743 CDD:240274 91/260 (35%)
Necessary and sufficient for ORC complex assembly 501..861 113/403 (28%)
Cdc6_C 778..857 CDD:462672 14/78 (18%)
Blue background indicates that the domain is not in the aligned region.

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