Protein Alignment Cdc6 and orc1

DIOPT Version :10

• Sequence 1: NP_648247.1
• Gene: Cdc6 / 38989
• FlyBaseID: FBgn0035918
• Length: 662
• Species: Drosophila melanogaster
• Sequence 2: NP_596060.1
• Gene: orc1 / 2540470
• PomBaseID: SPBC29A10.15
• Length: 707
• Species: Schizosaccharomyces pombe
• Alignment Length: 763
• Identity: 193/763 - (25%)
• Similarity: 299/763 - (39%)
• Gaps: 196/763 - (25%)

  Fly    29 PRRSEVWKRRQ------PKKVLAD-----SDEEEEVVTAIYDLTSPVSENNENRNVLNKMDK--I 80
            |||..:  |.|      .|.:|:|     ||.:||.|..::  |....:....|:....:.|  :
pombe     2 PRRKSL--RSQLLINGIDKSLLSDDSADSSDIDEEEVYGVW--TEEPFQKEAGRSYYRSLKKNDV 62

  Fly    81 SRRRTSQVQVAQS-------------ELPKTPRSTKKTVQSAGSSR--AKREE-------ENREA 123
            ..|....:.|...             |......|.||.|::...||  |||.|       .:|..
pombe    63 IYRVGDDITVHDGDSSFYLGVICKLYEKAIDKHSGKKYVEAIWYSRAYAKRMEIKPEYLLPDRHI 127

  Fly   124 TARFLEGEQD--------------SEVD-----PLHGSPPKQRKLQPLPQHLISPSRLLDRLSID 169
            ...::...:|              ||.:     |. |.|.|::.|.|....:    |....|.::
pombe   128 NEVYVSCGRDENLTSCIIEHCNVYSEAEFFSKFPA-GIPTKRKDLFPCNFFI----RRGVHLKVN 187

  Fly   170 ERQE-----------EEVEATTHKTETAEQQPKHQAKDEAKPRPKQQEDPLAQKQQEKPPTKQPN 223
            :..|           |.:|....:.|...:..|.::....:.||::.  ||...:.::..:|..:
pombe   188 KYTEPLDWSYYAHNLERIEDLLVEMEENLRPTKKKSGSRGRGRPRKY--PLPNVESKESSSKVNS 250

  Fly   224 KNQTKEKSNIQTNEETQQNNL----------------------PSPSRNKYQNAR-------RVL 259
            |:   |..::|.:.|:.::||                      .:|.||.|:...       |:|
pombe   251 KD---ENFDLQDDSESSEDNLTIQPQTPRRRHKRSRHNSSNLASTPKRNGYKQPLQITPLPIRML 312

  Fly   260 NSAETQNLPGRE-----------SQLQ----ELREFFSN---HLESQTSGSLYVSGQPGTGKTAC 306
            :..|.|..|.|:           |.||    |....|||   .:|.:|...||:||.|||||||.
pombe   313 SLEEFQGSPHRKARAMLHVASVPSTLQCRDNEFSTIFSNLESAIEEETGACLYISGTPGTGKTAT 377

  Fly   307 -------LSLLLRD---PDFSKRLQRVYINCTSIASVGAVYKKLCTELQ-LKVSGRTERDHLEAI 360
                   |..|.|:   |:||    ...||...:.|....|..|...|. .:|:.....|.|:..
pombe   378 VHEVIWNLQELSREGQLPEFS----FCEINGMRVTSANQAYSILWESLTGERVTPIHAMDLLDNR 438

  Fly   361 QRHLKTAKRMLLLVLDEIDQLCTSRQEVLYTIFEWPALPGSRILLVGIANSLDLTDRALM-RLNA 424
            ..|....:...::::||:|||.|..|:|||..|.||:||.||:::|.:||::||.:|.|. |:::
pombe   439 FTHASPNRSSCVVLMDELDQLVTHNQKVLYNFFNWPSLPHSRLIVVAVANTMDLPERILSNRISS 503

  Fly   425 RCELKPRLMHFPPYSKQQIVEIFKSRLAEAEVLDVFPPVTLQLLAAKVSAISGDVRRALDIGRRV 489
            |..|.  .:.|.||:..|:..|..:||......|||....::..|.||:|:|||.||||||.||.
pombe   504 RLGLS--RVPFEPYTHTQLEIIIAARLEAVRDDDVFSSDAIRFAARKVAAVSGDARRALDICRRA 566

  Fly   490 VEIAEQQKRDGEKEFNMKALQLEGKDAVEAKEKQDTLKPVQVTQ-----VAAVLNKVYGASQNLE 549
            .|:||                          .|...:.|..:.|     .|:.|.||.   :||
pombe   567 SELAE--------------------------NKNGKVTPGLIHQAISEMTASPLQKVL---RNL- 601

  Fly   550 EDIEASFPLQQKLMLCTLVLMLRNERNKDISMGRLHEVYRRVC---------AKRNILALDQAEF 605
                 ||  .||:.||.:|..:|.....:..:..:.|...|:.         ||...|.|.:.||
pombe   602 -----SF--MQKVFLCAIVNRMRRSGFAESYVYEVLEEAERLLRVMTTPDAEAKFGELILRRPEF 659

  Fly   606 TGTVDLVETRGILRIMRKKEPRLHKVLLQWDEEEVHAALSDKQLIASI 653
            ...:..:...|:| .:..|..|..:|.|...::|:..|......:|.|
pombe   660 GYVLSSLSENGVL-YLENKSSRNARVRLAIADDEIKLAFRGDSELAGI 706

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdc6	NP_648247.1	CDC6	256..646	CDD:441083	130/440 (30%)
orc1	NP_596060.1	BAH_Orc1p_like	34..193	CDD:240066	31/165 (19%)
		PTZ00112	<54..669	CDD:240274	168/667 (25%)