Protein Alignment Cdc6 and orc-1

DIOPT Version :10

• Sequence 1: NP_648247.1
• Gene: Cdc6 / 38989
• FlyBaseID: FBgn0035918
• Length: 662
• Species: Drosophila melanogaster
• Sequence 2: NP_499347.1
• Gene: orc-1 / 176486
• WormBaseID: WBGene00012650
• Length: 636
• Species: Caenorhabditis elegans
• Alignment Length: 718
• Identity: 171/718 - (23%)
• Similarity: 297/718 - (41%)
• Gaps: 154/718 - (21%)

  Fly     7 STRLSSISKATAASP----------LPPST-QTPRRSEVWKRRQPK----------KVLADSDEE 50
            :||.|..||..:|:|          ||.|. :..:||.|..|..|:          ...:|||.|
 Worm     2 NTRKSETSKTVSATPVKRRSTRITNLPKSAPKIVKRSSVRLRGAPQCTYKSDSSSSSSSSDSDGE 66

  Fly    51 EEV------VTAI-------YDLTSPVSEN---------NENRNVLNKMDKISRRRTSQVQVAQS 93
            :|.      :.|:       .|.:..:.||         .|||.|...........|...::|:
 Worm    67 DEYAATKDELKAVDHDNQMEIDFSDEIGENFSEEDSCSDKENRRVTRSRTPTRLEETPSKRLAR- 130

  Fly    94 ELPK---TPRSTKKTVQSAGSSRAKREEENREATARFLEGEQDSEVDPLHGSPPKQRKLQPLPQH 155
            ||.|   :..||.||:.....|..|.|...:...||..:.|.|.:.|...
 Worm   131 ELSKASVSKVSTSKTLFKESKSPRKVEISRKTNKARVFQEEDDDDEDDFS--------------- 180

  Fly   156 LISPSRLLDRLSIDERQEEEVEATTHKTETAEQQPKHQAKDEAKPRPKQQEDPLAQKQQEKPPTK 220
                         ||..|:....|..:|....:.|...               :.||......:|
 Worm   181 -------------DEIDEKFYSKTNKRTPITIKIPSKM---------------ITQKVTPLVISK 217

  Fly   221 QPNKNQTKEKSNIQTNEETQQNNLPSPSRNK---YQNARRVLNSAETQNLPGRESQLQELREFFS 282
            .|.......:...|.:||.:....|..||:.   .:.|.|:..|...:.||.|:.:.:|:.:|..
 Worm   218 TPGGTLRTRRRARQNSEELEDLVDPLDSRSASTLKELASRLHLSKVPEKLPCRDIESREIEKFIR 282

  Fly   283 NHLESQ--TSGSLYVSGQPGTGKTACLSLLLRDPDFSKRLQR-VYINCTSIASVGAVYKKLCTEL 344
            ..::.:  .|.::|:||.|||||||.:..::.....||:.|: ||:...::.....|:.::...:
 Worm   283 EVIDPKRGESSAMYISGVPGTGKTATVRAVVNSMKKSKKCQKFVYVEVNAMIFKKTVFVEIYNGI 347

  Fly   345 Q-----------LKVSGRTERDHLEAIQRHLKTAKRMLLLVLDEIDQLCTSRQEVLYTIFEWPAL 398
            |           .|::....|..|.:|.:.....:..:::::||:|.||..:|:|||.||||.||
 Worm   348 QEEYNISKKPQRAKITATAARQELNSIFKREDPKRPPIVVLIDELDSLCNRKQDVLYDIFEWTAL 412

  Fly   399 PGSRILLVGIANSLDLTDRALMRLNARCELKPRLMHFPPYSKQQIVEIFKSRLAEAEVLDVFPPV 463
            |.|::.::||||:||..:|.|.:.|| ..|..|.:.|.||..:||.||.::||..:.::|   |.
 Worm   413 PQSKVTIIGIANTLDFPERMLCQRNA-SRLDKRRLVFQPYQHEQIEEIVRARLQGSNLID---PK 473

  Fly   464 TLQLLAAKVSAISGDVRRALDIGRRVVEIAEQQKRDGEKEFNMKALQLEGKDAVEAKEKQDTLKP 528
            .::|:|.||:..:||:|:|||...|.:.:|.::|                      .||
 Worm   474 AVELVAKKVAMNTGDLRQALDFLCRAIRVAVERK----------------------SEK------ 510

  Fly   529 VQVTQVAAVLNKVYGASQNLEEDIEASFPLQQKLMLCTLVLMLRNERNKDISMGRLHEVYRRVCA 593
            ::::.|.|..|.|.   :.|:..:.....|.|..:..|:..|.|.:  ::|....:::.|..:|:
 Worm   511 LELSHVIAAQNAVL---EPLKYRLVKGLRLHQFTLFRTIESMTREQ--EEIIFANIYKNYCIICS 570

  Fly   594 KRNIL--ALDQAEFTGTVDLVETRGILRI------MRKKEPRLHKVLLQWDEEEVHAALSDKQLI 650
            :.:.:  |.|...:...:.|..| .::.:      |..:..:|....:: .|:.:.||:...:.|
 Worm   571 EVSGIGPATDSFAYGMLLQLAST-SLINLSKGDHGMMNRRVKLGMTSME-AEKAIKAAIEKNKSI 633

  Fly   651 ASI 653
            .||
 Worm   634 YSI 636

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdc6	NP_648247.1	CDC6	256..646	CDD:441083	106/411 (26%)
orc-1	NP_499347.1	CDC6	263..627	CDD:441083	103/402 (26%)