DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp66 and PDLIM7

DIOPT Version :9

Sequence 1:	NP_729395.2	Gene:	Zasp66 / 38988	FlyBaseID:	FBgn0035917	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_005442.2	Gene:	PDLIM7 / 9260	HGNCID:	22958	Length:	457	Species:	Homo sapiens

Alignment Length:	352	Identity:	72/352 - (20%)
Similarity:	116/352 - (32%)	Gaps:	76/352 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 PSPCRRRSSSGLKKRVHFADEQNVGVQV------GSPAHGELLRGDIISKIGEYDARDLSHADAQ 101
            |:|...|...|        .:.||.:.:      |..|...:..||.:..|...:|..|:|.:||
Human    11 PAPWGFRLQGG--------KDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGSLTHIEAQ 67

  Fly   102 QLFRGAGNEIRLVVHRDNKIAYTQGATQEA------------GPGSRSNSTL------PPVTPDL 148
            ...|..|..:.|.:.|...:   |...|:|            .|....|.|.      ||.  |.
Human    68 NKIRACGERLSLGLSRAQPV---QSKPQKASAPAADPPRYTFAPSVSLNKTARPFGAPPPA--DS 127

  Fly   149 MPHRGPSPFLP--GPSHFERALQLPVDTLPQTVFPQLNSSGGYEVPSTVFSPKPTRDHQQDVDEE 211
            .|.:...|..|  ..:..:|.::...|..|:   |....|..:.:.:.:..    .:..||.|||
Human   128 APQQNGQPLRPLVPDASKQRLMENTEDWRPR---PGTGQSRSFRILAHLTG----TEFMQDPDEE 185

  Fly   212 QAAIVNQPYRTTPLVLPGAKVKKDAPTTESYLRHYPNPAVRAHPGHD--YHDSIMKQRVADTMLH 274
            .....:|..||          :..||.:.:....:|.|...:.....  ..|....:|.|.
Human   186 HLKKSSQVPRT----------EAPAPASSTPQEPWPGPTAPSPTSRPPWAVDPAFAERYAP---- 236

  Fly   275 KVVGSEADTGRVFHKQFNSPIGLYSNNNIEDTIRSTVPFATSESNRLKDSPLHRPLPTKLNG-YK 338
                .:..|....|.|..:|..|.|..:|.......||...|.:.:   :|:.......:.| |.
Human   237 ----DKTSTVLTRHSQPATPTPLQSRTSIVQAAAGGVPGGGSNNGK---TPVCHQCHKVIRGRYL 294

  Fly   339 KTV--QYDPRN---SETYRAIQEEGGY 360
            ..:  .|.|..   |:..:.: ||||:
Human   295 VALGHAYHPEEFVCSQCGKVL-EEGGF 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp66	NP_729395.2	PDZ_signaling	<68..115	CDD:238492	13/52 (25%)
Zasp66	NP_729395.2	DUF4749	285..359	CDD:292558	17/79 (22%)
PDLIM7	NP_005442.2	PDZ_signaling	5..79	CDD:238492	18/75 (24%)
		Atrophin-1	<81..254	CDD:331285	37/202 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	82..142		13/64 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	176..226		12/59 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	239..258		5/18 (28%)
		LIM1_Enigma	282..333	CDD:188836	9/40 (23%)
		LIM2_Enigma	341..392	CDD:188840
		LIM3_Enigma	400..454	CDD:188842
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	71	1.000	Inparanoid score	I5310
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24214
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.180