DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp66 and MPDZ

DIOPT Version :9

Sequence 1:	NP_729395.2	Gene:	Zasp66 / 38988	FlyBaseID:	FBgn0035917	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_001362342.1	Gene:	MPDZ / 8777	HGNCID:	7208	Length:	2103	Species:	Homo sapiens

Alignment Length:	375	Identity:	73/375 - (19%)
Similarity:	128/375 - (34%)	Gaps:	93/375 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 HGELLRGDIISKIGEYDARDLSHADAQQLFRGAGNEIRLVVHR---DNKIAYTQ-GATQEAGPGS 135
            ||.|..||.|.|||:.|...:|.....|:.|..||.::|::.|   :.:.|.|. |.|..:.|
Human   293 HGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSSP-- 355

  Fly   136 RSNSTLPPVTPDLMPHRGPSPFLPGPSHFERALQLPVDTLPQTVF-----PQLNSSGGYEVPSTV 195
               ::.|.:..|....:|..     ...|:..|...|..|..|:.     .:|..||.: |.|..
Human   356 ---TSTPELRVDASTQKGEE-----SETFDVELTKNVQGLGITIAGYIGDKKLEPSGIF-VKSIT 411

  Fly   196 FSPKPTRDHQQDVDEEQAAIVNQPYRTTPLVLPGAKVKKDAPTTESYLRHYPNPAVRAHPGHDYH 260
            .|.....|.:..:.::..|:                   |....:.:........:| |.|....
Human   412 KSSAVEHDGRIQIGDQIIAV-------------------DGTNLQGFTNQQAVEVLR-HTGQTVL 456

  Fly   261 DSIMK---QRVADTMLHKVVGSEAD----TGRVFHKQFNSPIGLYS---NNNIEDTIRSTVPFAT 315
            .::|:   ::.|:.|..:.|..:||    ...:..:.:.......|   |.||..|.....|..:
Human   457 LTLMRRGMKQEAELMSREDVTKDADLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLS 521

  Fly   316 SESNRLKDSPLHR-PLPTKLN-----GYKKTVQYDPRNSET---------------YRAIQEEGG 359
            :|...::|:.... .|.||..     .|:..|.:..:.||.               .|::..||.
Human   522 AEIEEIEDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGP 586

  Fly   360 YSNYGQ-----------------SSPQEVT-----IPVQTKVYQPNRLVP 387
            ..:.|:                 .:.|:|.     :|::..:....|.||
Human   587 VGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVP 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp66	NP_729395.2	PDZ_signaling	<68..115	CDD:238492	16/39 (41%)
Zasp66	NP_729395.2	DUF4749	285..359	CDD:292558	17/97 (18%)
MPDZ	NP_001362342.1	PDZ_signaling	2019..2102	CDD:238492
		L27_2	6..63	CDD:312549
		PDZ_signaling	139..221	CDD:238492
		PDZ_signaling	257..334	CDD:238492	16/40 (40%)
		PDZ	374..463	CDD:214570	18/109 (17%)
		PDZ_signaling	560..629	CDD:238492	9/68 (13%)
		PDZ_signaling	698..784	CDD:238492
		PDZ_signaling	1006..1076	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1121..1140
		PDZ_signaling	1149..1240	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1278..1324
		PDZ	1347..1433	CDD:214570
		PDZ_signaling	1514..1593	CDD:238492
		MPDZ_u10	1595..1659	CDD:374710
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1600..1645
		PDZ	1660..1744	CDD:214570
		PDZ_signaling	1758..1836	CDD:238492
		PDZ_signaling	1893..1978	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900