DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp66 and LNX1

DIOPT Version :9

Sequence 1:	NP_729395.2	Gene:	Zasp66 / 38988	FlyBaseID:	FBgn0035917	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_001119800.1	Gene:	LNX1 / 84708	HGNCID:	6657	Length:	728	Species:	Homo sapiens

Alignment Length:	347	Identity:	71/347 - (20%)
Similarity:	125/347 - (36%)	Gaps:	103/347 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 ELPTSYRPQPTPKPPLVPLPSPCRRRSSSGLKKRVHFADEQNV---GVQVGSPA--HGELLRGDI 83
            :.|.:|||:......::...||   ....|: |.|...||..|   .|..|..|  ||:|...|.
Human   368 QAPDAYRPRDDSFHVILNKSSP---EEQLGI-KLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDR 428

  Fly    84 ISKIGEYDARDLSHADAQQLFRGAGNEIRLVVHRD---------NKIAYTQGATQEAGPGSRSNS 139
            :..|..:|.|..|...|..|.:.:...:.|||.|.         .:..:....:...|||.|||:
Human   429 VLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNT 493

  Fly   140 TLPPVTPDLMPHRGPSPFLPGPSHFERALQL---PVDTLPQTVFPQLNSSGG-----YEVPSTVF 196
                          |.|..|..:..|:.:.:   |.::|..||      :||     :::|..|.
Human   494 --------------PKPLHPTITCHEKVVNIQKDPGESLGMTV------AGGASHREWDLPIYVI 538

  Fly   197 SPKP-----------TRDHQQDVD---------EEQAAIVNQPYRTTPLVLPGAKVKKDAPTTES 241
            |.:|           |.|...:||         .|..|::.:  .::.:||...:||:..|..:.
Human   539 SVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKR--TSSSIVLKALEVKEYEPQEDC 601

  Fly   242 YLRHYPNPAV------RAHPG----------------HDYHDSIMKQRVADTMLHKVVGSEADTG 284
                 .:||.      .|.|.                ::..|.::::..|.::...:||.
Human   602 -----SSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGG----- 656

  Fly   285 RVFHKQFNSPIGLYSNNNIEDT 306
               ::::|.....:..:.:|.|
Human   657 ---YEEYNGNKPFFIKSIVEGT 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp66	NP_729395.2	PDZ_signaling	<68..115	CDD:238492	14/48 (29%)
Zasp66	NP_729395.2	DUF4749	285..359	CDD:292558	3/22 (14%)
LNX1	NP_001119800.1	mRING-HC-C3HC3D_LNX1	38..79	CDD:319693
		modified RING-HC finger (C3HC3D-type)	41..78	CDD:319693
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	178..214
		NPXY motif	181..184
		Interaction with MAGEB18. /evidence=ECO:0000269\|PubMed:20864041	186..244
		PDZ_signaling	272..355	CDD:238492
		PDZ_signaling	380..460	CDD:238492	22/83 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	475..494		6/32 (19%)
		PDZ_signaling	505..588	CDD:238492	18/90 (20%)
		PDZ_signaling	637..721	CDD:238492	7/47 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900